High-dose chemotherapy with autologous peripheral blood stem cell transplantation for bone and soft-tissue sarcomas

Kasper, Bernd; Lehnert, T.; Bernd, L.; Mechtersheimer, Gunhild; Goldschmidt, Hartmut; Ho, A. D.; Egerer, Gerlinde

doi:10.1038/sj.bmt.1704520

Cited by 42 publications

(29 citation statements)

References 27 publications

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“…4,14 Febrile neutropenia was a manageable toxicity and seemed to be lower, as reported in the literature, with similar regimens used. 14 The major problem with this regimen was encephalopathy that occurred in 31% (all grades) of chemotherapy cycles.…”

Section: Discussionsupporting

confidence: 52%

“…These results are very difficult to compare with other results obtained with HDCT because Table 3 Description of all patients including response to previous treatment, response, PFS to HD-ICE+ bevacizumab mostly patients with chemosensitive, non-refractory sarcomas were included in these trials. 4,23 In the study by Kasper et al 4 HD-ICE and HD melphalan were used. In this trial, 44% of the patients included were chemotherapy naive.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] However, in some phase I trials using HDCT, long-term survivors have been reported. 4 In patients with germ cell cancer (GCC) resistant to platinum-based chemotherapy, the therapeutic outcome is also very poor. The role of HDCT in this setting is still a matter of debate, but it might be beneficial as salvage therapy, as suggested by the European Germ Cell Cancer Consensus Group.…”

Section: Introductionmentioning

confidence: 99%

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Bevacizumab in combination with sequential high-dose chemotherapy in solid cancer, a feasibility study

Jordan

Wolf

Voigt

et al. 2010

Bone Marrow Transplant

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bevacizumab in combination with sequential high-dose chemotherapy in solid cancer, a feasibility study

Jordan

Wolf

Voigt

et al. 2010

Bone Marrow Transplant

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“…One year and 2 months postoperatively, no recurrence was seen on MRI, and after 1 year and 5 months, PBSCT with megatherapy was performed. Although PBSCT has not been proven to be effective for solid tumors, a few reports show that PBSCT is effective when performed in the state of complete response (CR) [16,17]. However, local radiotherapy, surgical decompression, and chemotherapy have all been advocated previously, and no randomized, controlled studies or prospective studies compare their short-and long-term outcomes.…”

Section: Discussionmentioning

confidence: 99%

Ewing sarcoma of the thoracic epidural space in a young child

et al. 2012

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Purpose To report on the clinical course and treatment of Ewing sarcoma of the thoracic epidural space in a 5-yearold girl. Methods We present the case of a 5-year-old girl who experienced back pain (day 1); on day 10, the pain had exacerbated and involuntary movements in the lower limbs occurred, and an MRI performed in her local hospital revealed a tumor lesion at the upper thoracic level. Results On day 13, emergency surgery was performed for partial resection of the tumor. Pathological examination of the resected tumor by immunostaining and gene testing revealed that it was MIC2 positive and an EWS-FLI 1 chimera, respectively, and Ewing sarcoma was diagnosed. The involuntary movements resolved immediately after the surgery. Three weeks after the operation, chemotherapy and radiation therapy were commenced. After 5 months, deep tendon reflexes recovered to normal. MRI showed that the tumor has not recurred at 29 months after surgery. Conclusions The majority of epidural patients undergo emergency surgery only after symptom exacerbation, which includes the development of neurological deficits. Thus, preoperative diagnosis of Ewing sarcoma of the epidural space is difficult and diagnosis is frequently made by a post-operative gene test. The resection area is limited to the intralesional margin area because a larger resection is difficult due to the characteristics of the affected region; thus, there is a higher possibility of recurrence and careful follow-up of the case is necessary.

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“…Wide excision of tumors in conjunction with multiagent chemotherapy now provides 5-year diseasespecific survivals ranging from 60% to 80% in patients with localized high-grade sarcomas [2,5,27]. Despite this success, the outcomes of patients who have metastatic disease at diagnosis or those with tumors showing a poor response to chemotherapy are still unsatisfactory (5-year disease-specific survival rates, 20%-40%), even with doseintensive or high-dose chemotherapy [9,18,19,33]. For improving the prognosis of patients with these difficult-totreat sarcomas, it is imperative to develop new targeted therapeutic strategies based on an understanding of the biologic mechanisms underlying the metastasis and chemoresistance of these tumors.…”

Section: Introductionmentioning

confidence: 99%