Abstract:Eight patients with advanced malignant melanoma were treated with high-dose melphalan (80–90 mg/m2) and BCNU (600–800 mg/m2). In all patients autologous bone marrow preservation was performed prior to therapy. Bone marrow was stored for 48 h in a refrigerator at 10°C and reinfused 48 h post-therapy. Three patients had a complete response (CR), 1 a partial response and 4 patients no response. Two patients with CR died 4 and 5 months after therapy. One had an interstitial pneumonitis and 1 … Show more
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