High dose calcitriol may reduce thrombosis in cancer patients

Beer, Tomasz M.; Venner, Peter; Ryan, Christopher W.; Petrylak, Daniel P.; Chatta, Gurkamal S.; Ruether, J. Dean; N., Kim; Curd, John G.; DeLoughery, Thomas G.

doi:10.1111/j.1365-2141.2006.06322.x

Cited by 75 publications

(62 citation statements)

References 13 publications

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“…In addition to its proposed role in the pathogenesis of cancer, hypovitaminosis D is also associated with an increased risk of fractures, falls, cardiovascular and thrombotic events, and infections, which may also contribute to increased mortality (8,9,(29)(30)(31). This is supported by our previous results of the LURIC study that show an inverse association between serum 25(OH)D levels and all-cause mortality of the entire study cohort (32).…”

Section: Discussionsupporting

confidence: 79%

Low Serum Levels of 25-Hydroxyvitamin D Predict Fatal Cancer in Patients Referred to Coronary Angiography

Pilz

Dobnig

Winklhofer‐Roob

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Section: Discussionsupporting

confidence: 79%

Low Serum Levels of 25-Hydroxyvitamin D Predict Fatal Cancer in Patients Referred to Coronary Angiography

Pilz

Dobnig

Winklhofer‐Roob

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…6,32 Vitamin D may affect vascular endothelium directly through the renin-angiotensin axis 12 ; through effects on vascular smooth muscle, including cell proliferation, 13 infl ammation, 12 and thrombosis 14 ; and through effects on hyperparathyroid hormone. 15,16 We did not assess these factors directly, although we found an inverse relationship between 25(OH)D levels and CRP.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have also linked low levels to incident cardiovascular disease, 10 including myocardial infarction. 11 Low levels of vitamin D may alter the renin-angiotensin axis by direct suppression of renin gene expression 12 ; affect vascular endothelium through smooth muscle proliferation, 13 infl ammation, 12 and thrombosis 14 ; alter calcium channel fl uxes; and induce secondary hyperparathyrodism. Elevated parathyroid hormone has been linked to mortality in the elderly, 15 possibly through vascular effects, 16 although fi ndings regarding an association with cardiovascular mortality have been mixed.…”

mentioning

confidence: 99%

Vitamin D, Race, and Cardiovascular Mortality: Findings From a National US Sample

Fiscella¹,

Franks

2010

The Annals of Family Medicine

131

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PURPOSE Findings are confl icting about the relationship between vitamin D levels and cardiovascular mortality. We wanted to determine the contribution of vitamin D levels to black-white disparities in cardiovascular mortality. METHODSWe examined the association of serum 25(OH)D levels with cardiovascular mortality and its contribution to elevated risk among blacks through a retrospective cohort using baseline data from the third National Health and Nutrition Examination Survey 1988-1994 and cause-specifi c mortality through 2001 using the National Death Index. Using piecewise Poisson regression models, we examined the risk of cardiovascular death (coronary heart disease, heart failure, and stroke) by sample 25(OH)D quartile, adjusting for cardiovascular risk factors, and compared models of adjusted race-related cardiovascular mortality with and without further adjustment for 25(OH)D levels. RESULTSParticipants with 25(OH)D levels in the lowest quartile (mean = 13.9 ng/mL) compared with those in the 3 higher quartiles (mean = 21.6, 28.4, and 41.6 ng/mL) had higher adjusted risk of cardiovascular death (incident rate ratio [IRR] = 1.40; 95% confi dence interval [CI], 1.16 -1.70). The higher age-and sex-adjusted cardiovascular mortality observed in blacks vs whites (IRR = 1.38; 95% CI, 1.13-1.70) was attenuated (IRR = 1.14; 95% CI, 0.91-1.44) by adjustment for 25(OH)D levels and fully eliminated with further adjustment for income (IRR = 1.01; 95% CI, 0.82-1.24).CONCLUSIONS Low serum levels of 25(OH)D are associated with increased cardiovascular mortality in a nationally representative US sample. Black-white differences in 25(OH)D levels may contribute to excess cardiovascular mortality in blacks. Interventional trials among persons with low vitamin D levels are needed to determine whether oral supplementation improves cardiovascular outcomes. Ann Fam Med 2010;8:11-18. doi:10.1370 sion, diabetes, renal, heart and cerebrovascular disease) and subsequent cardiovascular mortality.Relative to whites, blacks have higher rates of many cardiovascular risk factors and higher age-and sexadjusted cardiovascular mortality.19 This higher risk is accounted for by traditional risk factors (many of which are more common among blacks) and by lower socioeconomic status (itself associated with traditional cardiovascular risk factors). 20,21 Low-socioeconomic status is associated with greater chronic stress, poorer access to health care, and fewer resources for ameliorating behavioral risk factors. Blacks have signifi cantly lower mean serum 25(OH)D levels, 3,22 related both to biological (increased skin pigmentation reducing activation of oral vitamin D 23) and social and behavioral (lower intake, 24 less sun exposure 25 ) factors. Thus, lower levels of 25(OH)D may contribute to blackwhite disparities in cardiovascular mortality acting through racial differences in both biological and social or behavioral factors that increase the risk of cardiovascular-related conditions and subsequent mortality.We examined whether (1) ser...

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“…16,17 There may be a rationale in vitD supplementation for the treatment/prevention of thrombosis. VDR activators may be the preferred choice as they modulate the expression of various factors involved in thrombogenicity, 18 while supplementation with 25-OH vitD in obese women has failed to show any improvement in haemostatic parameters as assessed by calibrated automated thrombogram.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and antiphospholipid syndrome

Andréoli

Piantoni

Dall’Ara

et al. 2012

Lupus

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Vitamin D (vitD) has been shown to have multiple immunomodulatory properties. Hypovitaminosis D has been described in many systemic autoimmune diseases. Antiphospholipid syndrome (APS), an autoimmune disease characterized by immunemediated thrombosis and pregnancy loss, is a peculiar model for studying vitD, since these patients do not usually have a full-blown autoimmune disease, nor do they have particular restrictions regarding sun exposure. We assessed 25-OH vitD levels in 115 APS and 128 normal healthy donors (NHD) with the LIAISON Õ chemiluminescent immunoassay by DiaSorin (Italy). Median values were lower in APS patients than in NHD, with the greatest difference occurring during summertime (p < 0.01), suggesting that APS patients may be somehow prevented from vitD generation upon sun exposure. In our cohort, APS patients may have been instructed to use sunscreens in the presence of positive antinuclear antibodies (ANA). Comparing patients with positive and negative ANA, we found comparable vitD levels during the summer. By subdividing APS patients according to clinical features, thrombotic APS patients showed significantly lower levels than did pure obstetric APS patients (p < 0.01). In conclusion, our study confirms previous reports of hypovitaminosis D in APS patients, making them more similar to patients with other systemic autoimmune diseases than NHD. Hypovitaminosis D may be part of the mosaic of factors that determine autoimmunity, rather than a consequence of chronic disease and its treatment. The observation that patients with thrombotic APS, an aggressive phenotype, may be more deficient than those with exclusive obstetric manifestations fits well with the beneficial effects of vitD on thrombosis described both in vitro and in vivo. Therefore, there may be a rationale to assess the efficacy of vitD supplementation in APS patients. Lupus (2012) 21, 736-740.

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High dose calcitriol may reduce thrombosis in cancer patients

Cited by 75 publications

References 13 publications

Low Serum Levels of 25-Hydroxyvitamin D Predict Fatal Cancer in Patients Referred to Coronary Angiography

Low Serum Levels of 25-Hydroxyvitamin D Predict Fatal Cancer in Patients Referred to Coronary Angiography

Vitamin D, Race, and Cardiovascular Mortality: Findings From a National US Sample

Vitamin D and antiphospholipid syndrome

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