High-dose bee venom exposure induces similar tolerogenic B-cell responses in allergic patients and healthy beekeepers

Boonpiyathad, Tadech; Meyer, Norbert; Moniuszko, Marcin; Sokołowska, Milena; Eljaszewicz, Andrzej; Wirz, Oliver F.; Tomasiak-Lozowska, Maria M.; Bodzenta-Łukaszyk, Anna; Ruxrungtham, Kiat; Veen, Willem van de

doi:10.1111/all.12966

Cited by 91 publications

(93 citation statements)

References 45 publications

(58 reference statements)

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“…PLA-specific IgG4-switched memory B cells expanded after exposure to bee venom. These findings suggested a similar functional immunoregulatory role for B cells in allergen tolerance in both groups [48].…”

Section: Hymenoptera Venom Allergysupporting

confidence: 52%

Regulatory B Cells and Allergy: Uncovering the Link

Mota¹,

Martins²,

Borrego³

2017

J Investig Allergol Clin Immunol

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Regulatory B (Breg) cells are recognized as immunosuppressive cells. During the last few years, several subsets of Breg cells with different phenotypes and suppressive mechanisms have been described in the literature. We review the role of Breg cells in allergy based on an extensive literature search in PubMed. We describe the types and mechanisms of action of B cells and their role in the pathogenesis of several allergic diseases (allergic asthma, allergic rhinitis, food allergy, contact hypersensitivity, and anaphylaxis). ResumenLos linfocitos reguladores del tipo B (B reg.) juegan un papel importante en el funcionamiento del sistema inmunitario. Durante los últimos años, se han descrito varios subgrupos de linfocitos B reg., con diferentes fenotipos y mecanismos supresores. Nuestro objetivo es recopilar la información existente sobre el papel de los linfocitos B reg. en Alergología, en base a una profunda investigación bibliográfica en PubMed. Describimos los tipos y mecanismos de acción de los linfocitos B y su función en la patogénesis de varias enfermedades alérgicas (asma alérgica, rinitis alérgica, alergia alimentaria, eccema de contacto y anafilaxia). Palabras clave: Linfocitos B reguladores. Alergia. Enfermedad alérgica. Tolerancia a alérgenos. B10. Br1. Asma. Alergia alimentaria. Alergia al veneno de himenópteros. Embarazo.

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Section: Hymenoptera Venom Allergysupporting

confidence: 52%

Regulatory B Cells and Allergy: Uncovering the Link

Mota¹,

Martins²,

Borrego³

2017

J Investig Allergol Clin Immunol

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“…These data clearly indicate that high doses of allergen exposure promote PLA‐specific Bregs expansion both in healthy beekeepers and bee venom allergic patients during AIT, suggesting the IL‐10‐producing Bregs might well play important functional roles in the induction and maintenance of allergen tolerance. In addition, it has been recently shown that PLA‐specific Bregs upregulate CCR5 expression, a marker expressed by Tregs that is needed for migration to inflamed tissues, in both healthy beekeepers and patients undergoing AIT after venom exposure . The overexpression of solely IL‐10 on human B cells demonstrated the importance of IL‐10 in Breg cells with the induction of a prominent immunoregulatory profile comprising upregulation of suppressor of cytokine signaling 3 (SOCS3), glycoprotein A repetitions predominant (GARP), the IL‐2 receptor α chain (CD25), and programmed cell death 1 ligand 1 (PD‐L1).…”

Section: The Role Of Regulatory B Cells In Allergic Diseasesmentioning

confidence: 99%

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

Palomares

Akdiş

Martín‐Fontecha

2017

Immunological Reviews

248

285

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Allergy is a major public health problem with a high socio-economic impact. The number of allergic patients is expected to reach to four billion within two decades when the World's population reaches to 10 billion. Our knowledge on the molecular mechanisms underlying allergic diseases and allergen tolerance induction had significant advances during the last years. Nowadays, it is well accepted that the generation and maintenance of allergen-specific regulatory T cells (Tregs) and regulatory B cells (Bregs) and the involvement of their suppressive cytokines and surface molecules are essential for the induction of allergen tolerance. These mechanisms play essential roles for the restoration of healthy immune responses to allergens in allergen-specific immunotherapy (AIT) and healthy immune response during high-dose antigen exposure in beekeepers and cat owners. AIT remains as the only disease-modifying and curative treatment for allergic diseases and represents a perfect model to investigate the antigen-specific immune responses in humans. A large number of clinical trials demonstrated AIT as an effective treatment in many patients, but it still faces several drawbacks in relation to efficacy, safety, long duration, and patient adherence. Novel strategies to overcome these inconveniences, such as the development of novel adjuvants and alternative routes of administration are being developed. The better understanding of the molecular mechanism governing the generation of Treg and Breg cells during allergen tolerance might well open new avenues for alternative therapeutic interventions in allergic diseases and help better understanding of other immune-tolerance-related diseases.

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“…T‐regulatory (Treg) cell subsets have distinct phenotypes and include constitutive and inducible subsets of CD4 + CD25 + Forkhead box P3 (FOXP3) + Treg cells and type 1 Treg cells (Tr1). As a second major player in immune regulation, IL‐10–producing B‐regulatory (Breg) cells have also been demonstrated to suppress allergen‐specific responses and promote IgG4 isotype antibodies . Allergen tolerance in high‐dose–exposed individuals such as beekeepers and cat owners, the AIT response, and protective effects of farm exposure make up one of the most representative areas where Treg and Breg cells display their major roles .…”

Section: Basic Mechanisms Of Allergic Diseases—key Questionsmentioning

confidence: 99%

Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care

Breiteneder

Diamant

Eiwegger

et al. 2019

Allergy

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This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. AbstractThe specialties of allergy and clinical immunology have entered the era of precision medicine with the stratification of diseases into distinct disease subsets, specific diagnoses, and targeted treatment options, including biologicals and small molecules.This article reviews recent developments in research and patient care and future trends in the discipline. The section on basic mechanisms of allergic diseases summarizes the current status and defines research needs in structural biology, type 2 inflammation, immune tolerance, neuroimmune mechanisms, role of the microbiome and diet, environmental factors, and respiratory viral infections. In the section on diagnostic challenges, clinical trials, precision medicine and immune monitoring Zuzana Diamanthttps://orcid.org/0000-0003-0133-0100Thomas Eiwegger https://orcid.org/0000-0002-2914-7829Wytske J. Fokkens https://orcid.org/0000-0003-4852-229X

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High-dose bee venom exposure induces similar tolerogenic B-cell responses in allergic patients and healthy beekeepers

Cited by 91 publications

References 45 publications

Regulatory B Cells and Allergy: Uncovering the Link

Regulatory B Cells and Allergy: Uncovering the Link

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care

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