1994
DOI: 10.1177/0310057x9402200505
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High-dose Aprotinin in Cardiac Surgery—A Prospective, Randomized Study

Abstract: Fifty patients undergoing primary coronary artery bypass surgery and 50 patients undergoing valve surgery received either high-dose aprotinin (2 million units loading dose, 2 million units added to the CPB prime, and 500,000 unitslhr maintenance infusion) or placebo. Mean postoperative blood loss in the first six hours was reduced from 321 ml in the placebo group to 172 ml in the aprotinin group (95 % confidence interval (Cl) for difference = 95 to 189 ml). Seven patients in the placebo group and 16 patients i… Show more

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Cited by 25 publications
(2 citation statements)
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“…The contact activation, which is the stimulator of intrinsic pathway of coagulation, is inhibited with aprotinin. In recent studies it has been shown that aprotinin prevents fibrinolysis by plasmin inhibition rather than kallikrein inhibition and prevents thrombocyte aggregation when applied in higher doses 8,9 , 19 . It also produces an antifibrinolytic effect by a decrease in the formation of fibrin degradation products, activation of α‐2‐antiplasmin, t‐PA inhibitors, and a decrease in release of t‐PA from endothelial cells 8,9 .…”
Section: Discussionmentioning
confidence: 99%
“…The contact activation, which is the stimulator of intrinsic pathway of coagulation, is inhibited with aprotinin. In recent studies it has been shown that aprotinin prevents fibrinolysis by plasmin inhibition rather than kallikrein inhibition and prevents thrombocyte aggregation when applied in higher doses 8,9 , 19 . It also produces an antifibrinolytic effect by a decrease in the formation of fibrin degradation products, activation of α‐2‐antiplasmin, t‐PA inhibitors, and a decrease in release of t‐PA from endothelial cells 8,9 .…”
Section: Discussionmentioning
confidence: 99%
“…A randomised, double-blind study from a single centre, on the effect of aprotonin on cardiac surgery (50 CABG cases and 50 valve cases), was conducted in the early 1990s at Groote Schuur Hospital 11. This study had exclusion criteria and was not representative of a cardiac surgical practice.…”
Section: Introductionmentioning
confidence: 99%