High dose administration of DREADD agonist JHU37160 produces increases in anxiety-like behavior in male rats

Savage, J.; Avegno, Elizabeth M.

doi:10.1016/j.bbr.2023.114553

Behavioural Brain Research

2023

DOI: 10.1016/j.bbr.2023.114553

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High dose administration of DREADD agonist JHU37160 produces increases in anxiety-like behavior in male rats

J. Savage

Elizabeth M. Avegno

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2024

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Ventral pallidal GABAergic neurons drive consumption in male, but not female rats

Scott,

Paulson,

Prill

et al. 2024

Preprint

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Food intake is controlled by multiple converging signals: hormonal signals that provide information about energy homeostasis, but also hedonic and motivational aspects of food and food cues that can drive non-homeostatic or hedonic feeding. The ventral pallidum (VP) is a brain region implicated in the hedonic and motivational impact of food and foods cues, as well as consumption of rewards. Disinhibition of VP neurons has been shown to generate intense hyperphagia, or overconsumption. While VP gamma-Aminobutyric acidergic (GABA) neurons have been implicated in cue-elicited reward seeking and motivation, the role of these neurons in the hyperphagia resulting from VP activation remains unclear. Here, we used Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) to activate or inhibit VP GABA neurons in sated male and female rats during chow and sucrose consumption. We found that activation of VP GABA neurons increases consumption of chow and sucrose in male rats, but not female rats. We also found that, while inhibition of VP GABA neurons tended to decrease sucrose consumption, this effect was not statistically significant. Together, these findings suggest that activation of VP GABA neurons can stimulate consumption of routine or highly palatable rewards selectively in male rats.

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Ventral pallidal GABAergic neurons drive consumption in male, but not female rats

Scott,

Paulson,

Prill

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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High dose administration of DREADD agonist JHU37160 produces increases in anxiety-like behavior in male rats

Cited by 1 publication

References 13 publications

Ventral pallidal GABAergic neurons drive consumption in male, but not female rats

Ventral pallidal GABAergic neurons drive consumption in male, but not female rats

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