High-Dosage Vitamin E Supplementation and All-Cause Mortality

DeZee, Kent J.; Shimeall, William T.; Douglas, Kevin; Jackson, Jeffrey L.

doi:10.7326/0003-4819-143-2-200507190-00024

Cited by 10 publications

(4 citation statements)

References 5 publications

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“…There is some reason for caution with respect to high level human dosing in patients with compromised health status; one meta-analysis of the dose-response relationship between vitamin E supplements and all-cause mortality revealed an increase in all-cause mortality and resulted in the author's recommendation to avoid vitamin E supplements ≥ 400 IU/day (114). That meta-analysis has been criticized based on multiple issues (115–120). Current US UL for healthy adults is 1000 mg/day, corresponding to 1500 IU/day.…”

Section: Discussionmentioning

confidence: 99%

Nutrient plasma levels achieved during treatment that reduces noise-induced hearing loss

Prell

Dolan

Bennett

et al. 2011

Translational Research

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Hearing loss encompasses both temporary and permanent deficits. If temporary threshold shift (TTS) and permanent threshold shift (PTS) share common pathological mechanisms, then agents that reduce PTS should also reduce TTS. Several antioxidant agents have reduced PTS in rodent models; however, reductions in TTS have been inconsistent. This study first determined whether dietary antioxidants (beta-carotene, and vitamins C and E) delivered in combination with magnesium (Mg) reliably increase plasma concentrations of the active agents. Then, additional manipulations tested the hypothesis that these nutrients reduce acute TTS insult in the first 24 hours following loud sound, as well as longer lasting changes in hearing measured up to 7 days post-noise. Saline or nutrients were administered to guinea pigs prior to and after noise exposure. Sound-evoked electrophysiological responses were measured before noise, with tests repeated 1-hour post-noise, as well as 1-, 3-, 5-, and 7-days post-noise. All subjects showed significant functional recovery; subjects treated with nutrients recovered more rapidly, and had better hearing outcomes at early post-noise times as well as the final test time. Thus, this combination of nutrients, which produced significant increases in plasma concentrations of vitamins C and E and Mg, effectively reduced hearing loss at multiple post-noise times. These data suggest free radical formation contributes to TTS as well as PTS insults, and suggest a potential opportunity to prevent TTS in human populations.

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Section: Discussionmentioning

confidence: 99%

Nutrient plasma levels achieved during treatment that reduces noise-induced hearing loss

Prell

Dolan

Bennett

et al. 2011

Translational Research

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show abstract

“…Though, a recent meta-analysis of 19 clinical trials concluded that the regular administration of high-dose vitamin E supplements (P400 IU/day) is associated with a small but statistically significant increase of mortality (Miller et al, 2005). A number of critical comments were addressed to Miller and colleagues' metaanalysis regarding the statistical methods used, the lack of controlling for study quality and publication or selection bias (see Baggott, 2005;Blatt and Pryor, 2005;DeZee et al, 2005;Hemila, 2005;Jialal and Devaraj, 2005;Krishnan et al, 2005;Lim et al, 2005;Marras et al, 2005;Meydani et al, 2005b;Miller et al, 2005;Possolo, 2005).…”

Section: Meta-analysesmentioning

confidence: 97%

Cellular, molecular and clinical aspects of vitamin E on atherosclerosis prevention

Munteanu¹,

Zingg

2007

Molecular Aspects of Medicine

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“…The analysis was highly disputed and criticized for inconsistencies, biased selection of studies included in the meta-analysis, and even for inappropriate handling of data [3,8,18,21,27,34,42,49,53,55,64]. However, the authors might not be completely wrong in view of recent reports on harmful effects of atocopherol supplementation.…”

Section: Meta-analyses Of the Intervention Studiesmentioning

confidence: 99%

Adverse effects of vitamin E by induction of drug metabolism

Brigelius‐Flohé

2007

Genes Nutr

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Observational studies with healthy persons demonstrated an inverse association of vitamin E with the risk of coronary heart disease or cancer, the outcome of large-scale clinical trials conducted to prove a benefit of vitamin E in the recurrence and/or progression of such disease, however, was disappointing. Vitamin E did not provide benefits to patients with cardiovascular diseases, cancer, diabetes or hypertension. Even harmful events and worsening of pre-existing diseases were reported, which are hard to explain. Since vitamin E is metabolized along the same routes as xenobiotics and induces drug-metabolizing enzymes in rodents, it is hypothesized that a supplementation with high dosages of vitamin E may also lead to an induction of the drug-metabolizing system in patients that depend on drug therapy. Compromising essential therapy might therefore outweigh any benefit of vitamin E in patients. It is recommended to work out at which threshold the drug-metabolizing system can be induced in humans before new trials with high dosages of vitamin E are started.

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High-Dosage Vitamin E Supplementation and All-Cause Mortality

Cited by 10 publications

References 5 publications

Nutrient plasma levels achieved during treatment that reduces noise-induced hearing loss

Nutrient plasma levels achieved during treatment that reduces noise-induced hearing loss

Cellular, molecular and clinical aspects of vitamin E on atherosclerosis prevention

Adverse effects of vitamin E by induction of drug metabolism

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