High dosage haloperidol therapy in chronic schizophrenic patients: A double-blind study of clinical response, side effects, serum haloperidol, and serum prolactin

Bjørndal, Niels; Bjerre, Marianne; Gerlach, Jes; Kristjansen, P.; Magelund, G.; Oestrich, Irene Henriette; Waehrens, J

doi:10.1007/bf00427590

Cited by 82 publications

(17 citation statements)

References 23 publications

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“…Since there is a trend in favor of the standard conditions, it is probable that the clinical experience available so far is inadequate for choice of an effective dose. This ap praisal is also consistent with the findings of other authors [Bjorndal et al" 1980;Modestin et al" 1983], Similar to antidepressant treatment, a consistent contin uous concentration of a rationally selected specific amount of neuroleptic appears to be more favorable with regard to the result of treatment than a dose which is continuously adapted in accordance with the current clinical impression. Frequent changing of the amount of neuroleptic administered for adaptation to the current psychological findings appears not to have a favorable effect on the course of the disease.…”

Section: Discussionsupporting

confidence: 80%

“…Bjorndal, 1980] give rise to doubt as to the practicability of this procedure. For this purpose, an experience which cannot be specified in detail, an intuitive feeling or a flair of the treating psy chiatrist is required, since objective criteria are still not known with the aid of which the amount of neuroleptic for the individual patient can be established.…”

Section: Introductionmentioning

confidence: 99%

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Experimental Comparison of the Effectivity of Individually Adapted and Standardized Dosages of Haloperidol

Klieser¹,

Lehmann²

1987

Neuropsychobiology

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Experimental tests of whether an individual neuroleptic treatment for compensation of acute schizophrenic disorders is more effective and has fewer side effects than a standard therapy were performed under double-blind conditions. For this purpose, a group of 16 patients was treated with 10 mg haloperidol/day for the duration of 14 days, and another group of 16 patients was treated with 20 mg haloperidol/day for the same period. 16 patients of a third group were treated for 14 days with an individual haloperidol dose adapted to the psychopathological findings. Patients were randomly allocated to the treatment groups. The medication was laid down in accordance with the randomization plan without informing the ward staff and raters by a leading physician of the hospital who was not involved in the data collection in the investigation. The psychological findings were registered by means of the BPRS and the global appraisal by the doctor (CGI) on days 0, 7 and 14. Extrapyramidal side effects were registered by means of the Simpson scale on days 0, 7 and 14. A superiority of the individually adapted treatment over standardized treatment could be demonstrated neither for the therapeutic target parameters nor for the side effect variables. On the contrary, a tendency to superiority in the groups treated with fixed doses was found. The results are discussed in terms of their significance for treatment practice.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Experimental Comparison of the Effectivity of Individually Adapted and Standardized Dosages of Haloperidol

Klieser¹,

Lehmann²

1987

Neuropsychobiology

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“…Almost invariably, patients had a diagnosis of schizo- Prien et al 1969Gardos et al 1974Quitkin el al. 1975Chien, 1975McClelland et al 1976Clark et al 1977Goldstein et al 1978Bjorndal et al 1980Branchey et al 1981Kane el al. 1983Nishikawa et al 1984Nishikawa et al 1985Nishikawa et al 1985Nishikawa et al 1985Marder et al 1987Carpenter el al.…”

Section: Resultsmentioning

confidence: 99%

Antipsychotic drugs: is more worse? a meta-analysis of the published randomized control trials

Bollini¹,

Pampallona²,

Orza³

et al. 1994

Psychol. Med.

117

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“…Most (Bjørndal et al 1980;Linkowski et al 1984;Meltzer et al 1983;Poland and Rubin 1981;Ravichandran et al 1984;Van Putten et al 1991) but not all (Aschauer et al 1988;Meltzer et al 1983) researchers who have evaluated the correlation between haloperidol plasma concentration and prolactin have reported significant correlations of varying strength (r = 0.43-0.97) in adult patients. Additionally, researchers who included female patients have reported correlations in some studies (Ravichandran et al 1984) but not others (Poland and Rubin 1981).…”

mentioning

confidence: 92%

Correlation of Antipsychotic and Prolactin Concentrations in Children and Adolescents Acutely Treated with Haloperidol, Clozapine, or Olanzapine

Alfaro

Wudarsky

Nicolson

et al. 2002

Journal of Child and Adolescent Psychopharmacology

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Patients with a Diagnostic and Statistical Manual of Mental Disorders (third edition, revised) diagnosis of schizophrenia or psychotic disorder not otherwise specified with onset of psychosis before the age of 13 participated in 6- to 8-week open or double-blind trials of haloperidol (n = 15, mean dose 15.4 +/- 8.1 mg/day [0.27 +/- 0.15 mg/kg/day]), clozapine (n = 30, mean dose 269.9 +/- 173.3 mg/day [4.4 +/- 2.6 mg/kg/day]), or olanzapine (n = 12, mean dose 17.5 +/- 2.8 mg/day [0.30 +/- 0.13 mg/kg/day]). Blood samples were obtained at 6 weeks for evaluation of haloperidol, reduced haloperidol, clozapine, desmethylclozapine, and olanzapine plasma concentrations and serum prolactin concentrations. No gender differences were noted for antipsychotic dose or concentration within each treatment group. Correlations between antipsychotic plasma concentration and serum prolactin concentration were significant only for the olanzapine treatment group (r = 0.80, p = 0.002). Separate correlations for gender were significant only for females receiving olanzapine (r = 0.91, p = 0.03); the patient with the highest serum prolactin experienced galactorrhea. Further studies evaluating the prolactin-elevating properties of antipsychotics are warranted in this population.

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High dosage haloperidol therapy in chronic schizophrenic patients: A double-blind study of clinical response, side effects, serum haloperidol, and serum prolactin

Cited by 82 publications

References 23 publications

Experimental Comparison of the Effectivity of Individually Adapted and Standardized Dosages of Haloperidol

Experimental Comparison of the Effectivity of Individually Adapted and Standardized Dosages of Haloperidol

Antipsychotic drugs: is more worse? a meta-analysis of the published randomized control trials

Correlation of Antipsychotic and Prolactin Concentrations in Children and Adolescents Acutely Treated with Haloperidol, Clozapine, or Olanzapine

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