High discordance in blood and genital tract HIV-1 drug resistance in Indian women failing first-line therapy

Abstract

We identified high resistance and high inter-compartmental resistance discordance in Indian women, which might lead to unrecognized resistance transmission and re-emergence compromising treatment outcomes, particularly relevant to countries like India, where sexual HIV transmission is predominant.

HIV drug resistance in various body compartments

“…A few reports found HIV drug resistance profiles in CVL and blood that were discordant [68][69][70]. Recent cases are included in Table 2 [71,72]. A study of women with virologic failure found complete concordance between blood plasma, blood cells, and genital tract in only 2 of 20 women with 14 having drug resistance mutations detected in genital tract but not in blood plasma [71].…”

“…Recent cases are included in Table 2 [71,72]. A study of women with virologic failure found complete concordance between blood plasma, blood cells, and genital tract in only 2 of 20 women with 14 having drug resistance mutations detected in genital tract but not in blood plasma [71]. It is, however, not known if these mutations would persist or would have impacted the treatment response.…”