High-Dimensional Mapping of the Hippocampus in Depression

Posener, Joel A.; Wang, Lei; Price, Joseph L.; Gado, Mokhtar H.; Province, Michael A.; Miller, Michael I.; Babb, Casey; Csernansky, John G.

doi:10.1176/appi.ajp.160.1.83

Cited by 187 publications

(125 citation statements)

References 38 publications

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“…MacQueen and colleagues 40 found a significant logarithmic association and Sheline and colleagues 41 a significant linear association between hippocampus volume and total illness duration. However, other studies 35,38,42 did not find any association between clinical variables and decreased volume in the hippocampus or amygdala. For the OFC, in agreement with our study, Bremner and colleagues 22 and Lacerda and colleagues 28 reported no significant association between OFC volume decrease and clinical variables.…”

Section: Discussionmentioning

confidence: 73%

Enhanced rostral anterior cingulate cortex activation during cognitive control is related to orbitofrontal volume reduction in unipolar depression

Wagner

Koch

Schachtzabel

et al. 2008

Journal of Affective Disorders

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Section: Discussionmentioning

confidence: 73%

Enhanced rostral anterior cingulate cortex activation during cognitive control is related to orbitofrontal volume reduction in unipolar depression

Wagner

Koch

Schachtzabel

et al. 2008

Journal of Affective Disorders

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“…Shape analysis has been shown to be complementary to volumetry in discriminating between normal and neuropsychiatric conditions (34,35). Recently, we used shape analysis to characterize basal ganglia structure in subjects with schizophrenia (36).…”

Section: Nih Public Accessmentioning

confidence: 99%

Basal Ganglia Shape Abnormalities in the Unaffected Siblings of Schizophrenia Patients

Mamah¹,

Harms²,

Wang³

et al. 2008

Biological Psychiatry

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Objective-Abnormalities of basal ganglia structure in schizophrenia have been attributed to the effects of antipsychotic drugs. Our aim was to test the hypothesis that abnormalities of basal ganglia structure are intrinsic features of schizophrenia, by assessing basal ganglia volume and shape in the unaffected siblings of schizophrenia subjects.Method-The study involved 25 pairs of schizophrenia subjects and their unaffected siblings and 40 pairs of healthy controls and their siblings. Large deformation, high-dimensional brain mapping was used to obtain surface representations of the caudate, putamen, and globus pallidus. Surfaces were derived from transformations of anatomical templates and shapes were analyzed using reduceddimensional measures of surface variability (i.e. principal components and canonical analysis). Canonical functions were derived using schizophrenia and control groups, and were then used to compare shapes in the sibling groups. To visualize shape differences, maps of the estimated surface displacement between groups were created.Results-In the caudate, putamen and globus pallidus, the degree of shape abnormality observed in the siblings of the schizophrenia subjects was intermediate between the schizophrenia subjects and the controls. In the schizophrenia subjects, significant correlations were observed between measures of caudate, putamen and globus pallidus structure and the selected measures of lifetime psychopathology.Conclusions-Attenuated abnormalities of basal ganglia structure are present in the unaffected siblings of schizophrenia subjects. This finding implies that basal ganglia structural abnormalities observed in subjects with schizophrenia are at least in part an intrinsic feature of the illness. KeywordsSchizophrenia; Siblings; Basal Ganglia; Caudate; Putamen; Globus Pallidus Corresponding Author: Daniel Mamah, M.D., M.P.E. Department of Psychiatry (Box 8134), Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, (314) 747-2160, Fax: (314) 747-2182, E-mail: mamahd@psychiatry.wustl.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Evidence from family, twin and adoption studies suggest that genetic factors play an important role in the pathogenesis of schizophrenia (1,2). Consistent with the involvement of genetic factors in schizophrenia, cognitive (3,4), neurologic (5,6) and neurobiological (7,8) abnormalities have been found in the unaffected relatives of schizophrenia subjects, generally in attenuated form. NIH Public AccessA number of lines of research suggest that basal ganglia abnormalities mi...

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“…In subjects with MDD or a history of MDD, MRI studies demonstrate reduced volume of the hippocampus (Bremner et al 2000;Frodl et al 2002;MacQueen et al 2003;Mervaala et al 2000;Shah et al 1998;Sheline et al 1996Sheline et al , 1999Steffens et al 2000; but not in Posener et al 2003;Rusch et al 2001;Vakili et al 2000). It appears that hippocampal atrophy is preferentially seen in older, recurrently depressed subjects or subjects who are refractory to antidepressant medications.…”

mentioning

confidence: 97%

Cellular changes in the postmortem hippocampus in major depression

Stockmeier

Mahajan

Konick

et al. 2004

Biological Psychiatry

638

370

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High-Dimensional Mapping of the Hippocampus in Depression

Abstract: Patients with major depression may have structural abnormalities of the hippocampus that can be detected by analysis of hippocampal shape but not volume. A specific defect in the subiculum could have widespread effects throughout neurocircuits that appear to be abnormal in depression.

Cited by 187 publications

References 38 publications

Enhanced rostral anterior cingulate cortex activation during cognitive control is related to orbitofrontal volume reduction in unipolar depression

Enhanced rostral anterior cingulate cortex activation during cognitive control is related to orbitofrontal volume reduction in unipolar depression

Basal Ganglia Shape Abnormalities in the Unaffected Siblings of Schizophrenia Patients

Cellular changes in the postmortem hippocampus in major depression

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