High dietary sodium augments vascular tone and attenuates low-flow mediated constriction in salt-resistant adults

Shenouda, Ninette; Ramick, Meghan G.; Lennon, Shannon L.; Farquhar, William B.; Edwards, David G.

doi:10.1007/s00421-020-04370-0

Cited by 9 publications

(8 citation statements)

References 31 publications

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“…Extracellular Na + is a primary determinant of plasma osmolarity and VSMCs tone [ 60 , 61 , 62 ]. It is finely maintained under normal conditions and in humans at a concentration between 135 and 145 mmol/L [ 60 ].…”

Section: High Sodium Salt-induced Salt-sensitive Memorymentioning

confidence: 99%

“…It is well known that Na + can have a direct effect on blood pressure [ 59 , 62 , 75 , 76 ]. Studies in hypertensive patients have shown that [Na + ] o increases by 1 to 3 mmol/L [ 63 , 77 ].…”

Section: High Sodium Salt-induced Salt-sensitive Memorymentioning

confidence: 99%

“…According to Kawasaki, the inability of the kidneys to excrete excess sodium may be either secondary to primary hyperaldosteronism or renal pathology or genetic [ 63 , 82 , 83 , 85 ]. Recently, attention is no longer directed solely to the kidneys but primarily to the vascular system [ 59 , 62 , 65 , 81 , 89 , 90 ]. Thus, particular interest has been focused on the first barrier located on the surface of the endothelium and vascular smooth muscle cells, the glycocalyx [ 2 , 74 , 91 , 92 ].…”

Section: High Sodium Salt-induced Salt-sensitive Memorymentioning

confidence: 99%

“…Knowing that VSMCs are the central contracting cells of the vascular wall, this slight increase in plasma sodium may lead to altered intracellular Na + and Ca 2+ homeostasis promoting hypertrophy and/or hyperplasia of these cells ( Figure 3 ) [ 2 , 97 , 98 , 99 ]. Eventually, this would promote increased peripheral resistance and blood pressure ( Figure 3 ) [ 62 , 91 ]. However, the mechanisms responsible for the increase in blood pressure still obscure.…”

Section: High Sodium Salt-induced Salt-sensitive Memorymentioning

confidence: 99%

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High Na+ Salt Diet and Remodeling of Vascular Smooth Muscle and Endothelial Cells

et al. 2021

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Our knowledge on essential hypertension is vast, and its treatment is well known. Not all hypertensives are salt-sensitive. The available evidence suggests that even normotensive individuals are at high cardiovascular risk and lower survival rate, as blood pressure eventually rises later in life with a high salt diet. In addition, little is known about high sodium (Na+) salt diet-sensitive hypertension. There is no doubt that direct and indirect Na+ transporters, such as the Na/Ca exchanger and the Na/H exchanger, and the Na/K pump could be implicated in the development of high salt-induced hypertension in humans. These mechanisms could be involved following the destruction of the cell membrane glycocalyx and changes in vascular endothelial and smooth muscle cells membranes’ permeability and osmolarity. Thus, it is vital to determine the membrane and intracellular mechanisms implicated in this type of hypertension and its treatment.

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Section: High Sodium Salt-induced Salt-sensitive Memorymentioning

confidence: 99%

Section: High Sodium Salt-induced Salt-sensitive Memorymentioning

confidence: 99%

Section: High Sodium Salt-induced Salt-sensitive Memorymentioning

confidence: 99%

Section: High Sodium Salt-induced Salt-sensitive Memorymentioning

confidence: 99%

See 2 more Smart Citations

High Na+ Salt Diet and Remodeling of Vascular Smooth Muscle and Endothelial Cells

et al. 2021

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“…Multifactorial combination of genetic, environmental, modifi cation in lifestyles and complex web of intravascular interactions of vasoactive substances and dietary factors other than sodium can play a role in the degree and etiology of persistent elevation in blood pressure in rodents and humans [4][5][6]. Experimental animal models have shown that Sprague-Dawley rats [(SDR, (inbred)] rapidly develop high blood pressure (>170 mm Hg) when fed 8% NaCl diet [7][8][9]. Hypertension is a major factor in the pathogenesis of several diseases including chronic kidney disease, stroke, and increase incidence of Cardiovascular Disease (CVD) although the eff ects of highsodium salt intake on haematological parameters has not been fully characterised.…”

mentioning

confidence: 99%

Assessment of Nanosilver Hemocompatibility in Prehypertensive Salt-Induced Animal Model

Uche¹,

Ohiambe²,

Amechina³

2021

J Biomed Res Environ Sci

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Aim: There are Conflicting reports on safety profile of nanoparticles on biological cells. This study evaluated the impact of nanosilver on hemocompatibility on salt-loaded rats. Materials and Methods: Sprague-Dawley rats [(inbred) (120-140 g)] randomly divided into of 4 groups, (n = 6) were studied. Group 1(control) received normal rat chow and tap water, Group 2 received rat chow containing 8% NaCl [(salt-loaded rats (SLRs)]. Group 3 received rat chow + Nanosilver Solution (NS) 0.18 mL 10 ppm/kg/day. Group 4 comprised SLRs + NS. After 6 weeks oral gavage treatments, measurements of Blood pressure (Bp) and Heart Rate (HR) were by pressure transducer via cannulation of left common carotid artery following anaesthesia with urethane. HR was computed by the number of arterial pulse per 60 seconds. 5 ml of blood for WBC, PLATELETS, RBC, PCV, HB, MCH, MCHC and MCV analyses using automated haematology analyser and Osmotic fragility reactivity with standard spectrophotometer at 540 nm wavelength. Results: Exposure of nanosilver to normotensive rats resulted in significantly lower RBC level compared with control, whereas RBC level in Salt-Loaded Co-Treated Nanosilver (SCNS) was comparable with the SLRs. The tenet was the same for HB, PCV, MCH and MCHC. Nanosilver induced leukopenia in normotensive compared with control and prevented WBC elevation in SCNS. Platelets significantly increased in Nanosilver-Treated Normotensive Rats (NTNRs) compared with control and decreased in SCNS. Osmotic burst resistance increased in NTNRs and decreased in cells from treated groups. Conclusion: Chronic exposure of nanosilver to salt loaded rats alters haematological parameters which may worsen circulatory function and activate risk factors of cardiovascular disorders.

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Mechanistic, participant, and movement-related factors that contribute to low-flow-mediated constriction

O’Brien,

Shivgulam

2023

Eur J Appl Physiol

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High dietary sodium augments vascular tone and attenuates low-flow mediated constriction in salt-resistant adults

Cited by 9 publications

References 31 publications

High Na+ Salt Diet and Remodeling of Vascular Smooth Muscle and Endothelial Cells

High Na+ Salt Diet and Remodeling of Vascular Smooth Muscle and Endothelial Cells

Assessment of Nanosilver Hemocompatibility in Prehypertensive Salt-Induced Animal Model

Mechanistic, participant, and movement-related factors that contribute to low-flow-mediated constriction

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