High dietary n6/n3 ratio decreases eicosapentaenoic to arachidonic acid ratios and upregulates NFκB/p50 expression in short-term low-dose streptozotocin and high-fructose rat model of diabetes

Starčević, Kristina; Roškarić, Petra; Šperanda, Marcela; Đidara, Mislav; Kurilj, Andrea Gudan; Maurić, Maja; Mašek, Tomislav

doi:10.1016/j.plefa.2019.07.008

Cited by 5 publications

(3 citation statements)

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“…Although unexpected, a high-fructose diet did not cause a significant increase in body weight, a finding similar to some previous studies [ 24 , 25 , 26 ]. Nevertheless, an important observation was that in human studies with fructose-supplemented diets, in which body weight did not increase, the deleterious effects on inflammation were still present [ 27 , 28 ].…”

Section: Discussionsupporting

confidence: 90%

Low Dietary n6/n3 Ratio Attenuates Changes in the NRF 2 Gene Expression, Lipid Peroxidation, and Inflammatory Markers Induced by Fructose Overconsumption in the Rat Abdominal Adipose Tissue

et al. 2021

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The objective of this study was to examine the benefits of different n6/n3 polyunsaturated fatty acid ratios on the lipid metabolism, insulin resistance, and oxidative stress in the adipose tissue of rats fed a high-fructose diet. Male and female rats were divided into four groups: a control group (CON) (n6/n3 ratio ~7), a high-fructose group (HF) (n6/n3 ratio ~7), an N6-HF group (n6/n3 ratio ~50), and the DHA-HF group (n6/n3 ratio ~1, with the addition of docosahexaenoic (DHA) and eicosapentaenoic (EPA) acid). The CON group received plain water and the HF group received 15% fructose in their drinking water. Fructose induced an increase in the content of serum triglycerides, serum cholesterol, and HOMA-IR index. Among the fatty acids, elevated proportions of C18:1n9 and C16:1n7, as well as an increase in total monounsaturated fatty acid (MUFA), were found in the adipose tissue of the HF group. Fructose treatment also changed oxidative parameters, including a marked increase in the serum malondialdehyde (MDA) content. Meanwhile, DHA supplementation caused a significant decrease in the serum MDA concentration in comparison with the HF group. In addition, DHA/EPA supplementation attenuated oxidative stress by increasing NRF 2 gene expression. Fructose treatment also significantly decreased the adiponectin level, while DHA supplementation ameliorated it. The changes observed in this trial, including the decrease in the content of DHA and EPA, the decreased EPA/ARA ratio, and the increase in the expression of inflammatory genes, are characteristics of the low-grade inflammation caused by fructose treatment. These changes in the rat adipose tissue could be prevented by dietary intervention consisting of DHA supplementation and a low n6/n3 ratio.

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Section: Discussionsupporting

confidence: 90%

Low Dietary n6/n3 Ratio Attenuates Changes in the NRF 2 Gene Expression, Lipid Peroxidation, and Inflammatory Markers Induced by Fructose Overconsumption in the Rat Abdominal Adipose Tissue

et al. 2021

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“…A previous review article indicated similar results to our findings concerning the association between MDA and SOD [4,64]. Furthermore, many previous studies have indicated that DHA/ARA ratios are important for lipid peroxidation [65][66][67]. Third, the ratio of control subjects to cases was small (2.3:1), and the average DHA/ARA ratio in the ASD group in the present study was 0.59 (2:3.79).…”

Section: Discussionsupporting

confidence: 89%

Lipid Peroxidation via Regulating the Metabolism of Docosahexaenoic Acid and Arachidonic Acid in Autistic Behavioral Symptoms

Yui,

Imataka,

Shiohama

2023

CIMB

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The association between the lipid peroxidation product malondialdehyde (MDA)-modified low-density lipoprotein (MDA-LDL) and the pathophysiology of autism spectrum disorder (ASD) is unclear. This association was studied in 17 children with ASD and seven age-matched controls regarding autistic behaviors. Behavioral symptoms were assessed using the Aberrant Behavior Checklist (ABC). To compensate for the small sample size, adaptive Lasso was used to increase the likelihood of accurate prediction, and a coefficient of variation was calculated for suitable variable selection. Plasma MDA-LDL levels were significantly increased, and plasma SOD levels were significantly decreased in addition to significantly increased plasma docosahexaenoic acid (DHA) levels and significantly decreased plasma arachidonic acid (ARA) levels in the 17 subjects with ASD as compared with those of the seven healthy controls. The total ABC scores were significantly higher in the ASD group than in the control group. The results of multiple linear regression and adaptive Lasso analyses revealed an association between increased plasma DHA levels and decreased plasma ARA levels, which were significantly associated with total ABC score and increased plasma MDA-LDL levels. Therefore, an imbalance between plasma DHA and ARA levels induces ferroptosis via lipid peroxidation. Decreased levels of α-linolenic acid and γ-linolenic acid may be connected to the total ABC scores with regard to lipid peroxidation.

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“…In a case-control evaluation of pulmonary and extrapulmonary findings of incidental asymptomatic COVID-19 infection 4:1 control:case ratio on the PET-CT scanning [70]. Moreover, in a previous case-control genomic study, ratios of up to 3:1 to 4:1 induced significant results in comparison to ratios of 1:1 or 2:1 [71]. Therefore, this ratio of our study (2.2:…”

Section: Discussionmentioning

confidence: 49%

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2023

Journal of Neurophysiology and Neurological Disorders

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Lipid peroxidation contributes to the development of autism spectrum disorder (ASD). Polyunsaturated fatty acids (PU-FAs) undergo lipid peroxidation, and conversion to malondialdehyde (MDA). MDA reacts with acetaldehyde to form malondialdehyde-modified low-density lipoprotein (MDA-LDL). MDA-LDL is known as a marker of lipid peroxidation.However, the association between PUFAs and MDA-LDL in the pathophysiology of ASD is unclear. We studied this association in 18 young individuals with ASD and 8 age-and sex-matched normal healthy controls. Social behaviors were assessed using the Social Responsiveness Scale (SRS). To overcome the small sample size, three measures were conducted: firstly, adaptive Lasso was used to enhance the accuracy of interpretability; second, the coefficient of variation was estimated for appropriate variable selection; and finally, appropriate variables were selected. Plasma MDA levels and DHA/omega 6 PUFA arachidonic acid ratio were significantly higher, whereas plasma levels of superoxide dismutase were significantly lower in the ASD group than in the control group. The total SRS scores in the ASD group were significantly higher than those in the control group. Multiple linear regression analysis and the adaptive Lasso revealed association of increased plasma DHA/ARA ratio with the SRS total scores and increased plasma MDA-LDL levels. These associations between plasma DHA/ARA ratio and increased plasma MDA-LDL levels contributed to autistic social behaviors.

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High dietary n6/n3 ratio decreases eicosapentaenoic to arachidonic acid ratios and upregulates NFκB/p50 expression in short-term low-dose streptozotocin and high-fructose rat model of diabetes

Cited by 5 publications

References 50 publications

Low Dietary n6/n3 Ratio Attenuates Changes in the NRF 2 Gene Expression, Lipid Peroxidation, and Inflammatory Markers Induced by Fructose Overconsumption in the Rat Abdominal Adipose Tissue

Low Dietary n6/n3 Ratio Attenuates Changes in the NRF 2 Gene Expression, Lipid Peroxidation, and Inflammatory Markers Induced by Fructose Overconsumption in the Rat Abdominal Adipose Tissue

Lipid Peroxidation via Regulating the Metabolism of Docosahexaenoic Acid and Arachidonic Acid in Autistic Behavioral Symptoms

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