High dietary choline and betaine intake is associated with low insulin resistance in the Newfoundland population

Gao, Xiang; Wang, Yongbo; Sun, Guang

doi:10.1016/j.nut.2016.08.005

Cited by 49 publications

(46 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings are supported by a cross-sectional study that found a beneficial association between dietary choline intake and glucose metabolism indices among men and women with the mean age of 43.4 years and the mean choline intake of 305 mg/day [4]. However, our results are in contrast with a large prospective study from Harvard that pooled results from the Nurses' Health Study I and II and the Health Professionals Follow-up Study and found that higher phosphatidylcholine intake was associated with increased risk of T2D and suggested conversion to TMAO as a possible explanation for the association [5].…”

Section: Discussionsupporting

confidence: 85%

“…However, few studies have investigated this association and the findings are mixed. In one cross-sectional study, a higher dietary choline intake was associated with lower insulin resistance [4]. An opposite finding was obtained from a large prospective study, which found a higher risk of incident T2D with a higher dietary phosphatidylcholine intake [5].…”

Section: Introductionmentioning

confidence: 92%

See 1 more Smart Citation

Dietary intake of choline and phosphatidylcholine and risk of type 2 diabetes in men: The Kuopio Ischaemic Heart Disease Risk Factor Study

2020

View full text Add to dashboard Cite

Purpose To investigate associations of total dietary choline intake and its major dietary form, phosphatidylcholine, with type 2 diabetes risk. Methods We included 2332 men aged 42-60 years at baseline in 1984-1989 from the Kuopio Ischaemic Heart Disease Risk Factor Study in eastern Finland. Dietary intakes were assessed with 4-d food recording at baseline. Type 2 diabetes diagnosis was based on self-administered questionnaires, fasting and 2-h oral glucose tolerance test blood glucose measurements, or by record linkage to national health registries. Multivariable-adjusted Cox proportional hazards regression models were used for statistical analysis. Results During the mean 19.3-year follow-up, 432 men had type 2 diabetes diagnosis. After multivariable adjustments, those in the highest vs. lowest choline intake quartile had 25% (95% CI 2-43%) lower relative risk (P trend across quartiles = 0.02) and those in the highest vs. lowest phosphatidylcholine quartile had 41% (95% CI 22-55%) lower relative risk (P trend < 0.001) of type 2 diabetes. Conclusions Higher choline intake, especially phosphatidylcholine, was associated with lower type 2 diabetes risk among men.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 92%

Dietary intake of choline and phosphatidylcholine and risk of type 2 diabetes in men: The Kuopio Ischaemic Heart Disease Risk Factor Study

2020

View full text Add to dashboard Cite

show abstract

“…Daily betaine intake was negatively associated with fasting plasma glucose and insulin resistance (HOMA-IR, QUICKI) in the large population-based CODING study (135), which would infer greater hepatic insulin sensitivity. This association further appeared to be dose-dependent and more pronounced in women (135). In a 1-yr pilot study, betaine improved steatosis, grade of necrosis, inflammation, and fibrosis in NASH patients (1).…”

Section: Ketoacid Derivatives and Amino Acids Improving Hepatic Insulmentioning

confidence: 96%

“…Lower circulating betaine levels have been reported in T2D and with poor glucometabolic control (374). In the population-based CODING study, daily betaine intake was negatively and dose-dependently associated not only with glycemia, but also with insulin resistance (HOMA-IR, QUICKI) (135,275). Higher betaine intake could be linked to lower circulating C-reactive protein and TNF-␣, which might contribute to beneficial effects on insulin sensitivity (95).…”

Section: B Ketoacid and Amino Acid Derivatives Improving Insulin Senmentioning

confidence: 98%

Interorgan Metabolic Crosstalk in Human Insulin Resistance

Gancheva

Jeleník

Álvarez-Hernández

et al. 2018

Physiological Reviews

154

111

View full text Add to dashboard Cite

Excessive energy intake and reduced energy expenditure drive the development of insulin resistance and metabolic diseases such as obesity and type 2 diabetes mellitus. Metabolic signals derived from dietary intake or secreted from adipose tissue, gut, and liver contribute to energy homeostasis. Recent metabolomic studies identified novel metabolites and enlarged our knowledge on classic metabolites. This review summarizes the evidence of their roles as mediators of interorgan crosstalk and regulators of insulin sensitivity and energy metabolism. Circulating lipids such as free fatty acids, acetate, and palmitoleate from adipose tissue and short-chain fatty acids from the gut effectively act on liver and skeletal muscle. Intracellular lipids such as diacylglycerols and sphingolipids can serve as lipotoxins by directly inhibiting insulin action in muscle and liver. In contrast, fatty acid esters of hydroxy fatty acids have been recently shown to exert a series of beneficial effects. Also, ketoacids are gaining interest as potent modulators of insulin action and mitochondrial function. Finally, branched-chain amino acids not only predict metabolic diseases, but also inhibit insulin signaling. Here, we focus on the metabolic crosstalk in humans, which regulates insulin sensitivity and energy homeostasis in the main insulin-sensitive tissues, skeletal muscle, liver, and adipose tissue.

show abstract

“…This finding suggested that the observed inverse association may be due to the modulation of endogenous metabolism mediated or moderated by compounds present in eggs. Noteworthy, eggs are an especially rich source of several bioactive compounds, such as carotenoids and choline, which have been shown to have beneficial effects on, for example, insulin resistance, inflammation, and lipid oxidation and metabolism …”

Section: Introductionmentioning

confidence: 99%

Metabolic Profiling of High Egg Consumption and the Associated Lower Risk of Type 2 Diabetes in Middle‐Aged Finnish Men

Noerman

Kärkkäinen

Mattsson

et al. 2018

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope Higher egg intake was previously associated with a lower risk of developing type 2 diabetes (T2D) in the prospective, population‐based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) in eastern Finland. Potential compounds that can explain this association are explored using nontargeted LC‐MS‐based metabolic profiling. Methods and results Two hundred and thirty‐nine baseline serum samples from the KIHD are analyzed in four groups: subjects with higher (mean intake one egg per day) or lower (mean intake two eggs per week) egg intake who developed T2D (cases) or remained heatlhy (controls) during the mean follow‐up of 19.3 years. Different serum profiles of subjects who had either higher or lower egg intakes, and of those who developed type 2 diabetes or remained healthy, are observed. The higher baseline tyrosine level predicts higher odds of T2D (OR 1.94; 95% CI 1.45, 2.60; p < 0.001; FDR 0.023) along with an unknown hexose‐containing compound (OR 2.13; 95% CI 1.57, 2.88; p < 0.001; FDR 0.005). Certain predominant metabolites in T2D cases are correlated positively with ones in the lower‐egg‐intake group and negatively with ones in the higher‐egg‐intake group. Conclusion Our current findings may underline some potential metabolites that can explain how egg intake is associated with a lower risk of T2D.

show abstract

High dietary choline and betaine intake is associated with low insulin resistance in the Newfoundland population

Cited by 49 publications

References 55 publications

Dietary intake of choline and phosphatidylcholine and risk of type 2 diabetes in men: The Kuopio Ischaemic Heart Disease Risk Factor Study

Dietary intake of choline and phosphatidylcholine and risk of type 2 diabetes in men: The Kuopio Ischaemic Heart Disease Risk Factor Study

Interorgan Metabolic Crosstalk in Human Insulin Resistance

Metabolic Profiling of High Egg Consumption and the Associated Lower Risk of Type 2 Diabetes in Middle‐Aged Finnish Men

Contact Info

Product

Resources

About