High diagnostic and clinical impact of small-bowel capsule endoscopy in patients with hereditary hemorrhagic telangiectasia with overt digestive bleeding and/or severe anemia

Gastrointestinal Manifestations of Hereditary Hemorrhagic Telangiectasia (HHT): A Systematic Review of the Literature

“…Canzonieri et al [22] measured the extent of GI involvement in 22 men with HHT using EGD, VCE, and colonoscopy and found gastric and small bowel telangiectasias in 64 and 91% of HHT patients, respectively. Grève [23] reported similar findings in 46.7 and 86.7% of HHT patients, though this study was primarily composed of HHT2 patients. Chamberlain et al [24] used VCE to compare 32 patients with HHT to 48 members of the general population and found gastric telangiectasias in 29% and small bowel telangiectasias in 81% of the HHT group, compared to 0 and 21%, respectively, of the control group.…”

Endoscopic evaluation of gastrointestinal tract in patients with hereditary hemorrhagic telangiectasia and correlation with their genotypes

“…They found a higher prevalence of large telangiectases in HHT1 patients older than 50 years. Grève et al 22 detected gastric and small-bowel telangiectases with VCE in 46.7 and 86.7% of 30 cases with HHT and severe anemia. Their population was essentially composed of patients with the ACVRL1 mutation.…”

“…Before our study, few papers evaluated small-bowel telangiectases in HHT patients with video capsule endoscopy (VCE), detecting telangiectases evenly distributed throughout the small bowel in 56-86% of HHT patients. [19][20][21][22] The aim of this study was to use gastroduodenoscopy (EGd), capsule endoscopy, and colonoscopy (CS) to explore the entire GI tract of consecutive middle-aged or older HHT patients to assess the distribution, number, size, and type of telangiectases in relation to HHT genotype.…”

Hereditary hemorrhagic teleangiectasia: the topical problems of diagnostics and surgical treatment

“…У 80% пациентов с НГТ, по данным эндоскопи ческих исследований, имеются телеангиэктазии в желудочнокишечном тракте (ЖКТ), у 15-45% из них развиваются ЖКК (обычно в возрасте 50-60 лет) [38][39][40][41]. Наиболее часто поражаемыми отдела ми ЖКТ являются желудок и тонкая кишка [27,39].…”