High density of nicotinic receptors in the cingulo-insular network

Picard, Fabienne; Sadaghiani, Sepideh; Leroy, Claire; Courvoisier, Delphine S.; Maroy, Renaud; Bottlaender, Michel

doi:10.1016/j.neuroimage.2013.04.074

Cited by 78 publications

(61 citation statements)

References 77 publications

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“…The frontal location of our nicotine effect is in line with Picard et al [52]. They used PET and radioligands for localizing the α 4 β 2 nicotinic receptors in humans.…”

Section: Discussionsupporting

confidence: 79%

“…Particularly interesting, they combined their results with the brain areas which were involved during EC activity within α activity in a previous EEG-fMRI study [48]. Picard et al [52] were able to demonstrate that the brain areas with the highest concentration of α 4 β 2 receptors were located within the insular and anterior cingulate cortex. Of note, our EC results showed the most significant clusters (the darkest spots in the figures) located in the region that could correspond perfectly to the cingulate: they are located close to the midline.…”

Section: Discussionmentioning

confidence: 98%

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EEG Source Reconstruction in Male Nonsmokers after Nicotine Administration during the Resting State

Ranzi

Thiel²,

Herrmann³

2016

Neuropsychobiology

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Modern psychopharmacological research in humans focuses on how specific psychoactive molecules modulate oscillatory brain activity. We present state-of-the-art EEG methods applied in a resting-state drug study. Thirty healthy male nonsmokers were randomly allocated either to a nicotine group (14 subjects, 7 mg transdermal nicotine) or a placebo group (16 subjects). EEG activity was recorded in eyes-open (EO) and eyes-closed (EC) conditions before and after drug administration. A source reconstruction (minimum norm algorithm) analysis was conducted within a frequency range of 8.5-18.4 Hz subdivided into three different frequency bands. During EO, nicotine reduced the power of oscillatory activity in the 12.5- to 18.4-Hz frequency band in the left middle frontal gyrus. In contrast, in the EC condition, nicotine reduced the power in the 8.5- to 10.4-Hz frequency band in the superior frontal gyri and in the 10.5- to 12.4-Hz and 12.5- to 18.4-Hz frequency bands in the supplementary motor areas. In summary, nicotine reduced the power of the 12.5- to 18.4-Hz band in the left middle frontal gyrus during EO, and it reduced power from 8.5 to 18.4 Hz in a brain area spanning from the superior frontal gyri to the supplementary motor areas during EC. In conclusion, the results suggest that nicotine counteracts the phenomenon of anteriorization of α activity, hence potentially increasing the level of vigilance.

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“…The frontal location of our nicotine effect is in line with Picard et al [52]. They used PET and radioligands for localizing the α 4 β 2 nicotinic receptors in humans.…”

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 98%

EEG Source Reconstruction in Male Nonsmokers after Nicotine Administration during the Resting State

Ranzi

Thiel²,

Herrmann³

2016

Neuropsychobiology

View full text Add to dashboard Cite

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“…Successful performance on the RVIP task is related to activation in the prefrontal cortex and parietal cortex, as well as the insula and anterior cingulate cortex (Lawrence et al, 2003), the latter two regions having relatively high densities of nicotinic acetylcholine receptors (Picard et al, 2013). Thus, improvements in sustained attention could reflect effects of nicotine in the insula and/ or anterior cingulate cortex.…”

Section: Discussionmentioning

confidence: 99%

Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects

Faulkner

Ghahremani

Tyndale

et al. 2017

Neuropsychopharmacol

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The use of cigarettes delivering different nicotine doses allows evaluation of the contribution of nicotine to the smoking experience. We compared responses of 46 young adult smokers to research cigarettes, delivering 0.027, 0.110, 0.231, or 0.763 mg nicotine, and conventional cigarettes. On five separate days, craving, withdrawal, affect, and sustained attention were measured after overnight abstinence and again after smoking. Participants also rated each cigarette, and the nicotine metabolite ratio (NMR) was used to identify participants as normal or slow metabolizers. All cigarettes equally alleviated craving, withdrawal, and negative affect in the whole sample, but normal metabolizers reported greater reductions of craving and withdrawal than slow metabolizers, with dose-dependent effects. Only conventional cigarettes and, to a lesser degree, 0.763-mg nicotine research cigarettes increased sustained attention. Finally, there were no differences between ratings of lower-dose cigarettes, but the 0.763-mg cigarettes and (even more so) conventional cigarettes were rated more favorably than lower-dose cigarettes. The findings indicate that smoking-induced relief of craving and withdrawal reflects primarily non-nicotine effects in slow metabolizers, but depends on nicotine dose in normal metabolizers. By contrast, relief of withdrawal-related attentional deficits and cigarette ratings depend on nicotine dose regardless of metabolizer status. These findings have bearing on the use of reduced-nicotine cigarettes to facilitate smoking cessation and on policy regarding regulation of nicotine content in cigarettes. They suggest that normal and slow nicotine metabolizers would respond differently to nicotine reduction in cigarettes, but that irrespective of metabolizer status, reductions to o0.763 mg/cigarette may contribute to temporary attentional deficits.

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“…Within the human cerebral cortex, the insula has the highest density of nicotinic acetylcholine receptors, as indicated by positron emission tomography using 2-[ 18 F]F-A-85380 (Picard et al, 2013), a tracer for nicotinic acetylcholine receptors containing b2 subunits (Kimes et al, 2003). Damage to the insular cortex, but not to other parts of the brain, disrupts smoking behavior in stroke patients and animals (Naqvi et al, 2007;Scott and Hiroi, 2011).…”

Section: Introductionmentioning

confidence: 99%

Cigarette Exposure, Dependence, and Craving Are Related to Insula Thickness in Young Adult Smokers

Morales

Ghahremani

Kohno

et al. 2014

Neuropsychopharmacol

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The age period spanning late adolescence to emergent adulthood is associated with the highest prevalence of cigarette smoking in the United States, and is also a time of continued brain development. Nonetheless, although prior research has shown group differences in brain structure associated with smoking status in adults, few studies have examined how smoking and associated behavioral states relate to brain structure in this age group. Neuroimaging and lesion studies have suggested that the insula, a cortical region that integrates heterogeneous signals about internal states and contributes to executive functions, plays an important role in cigarette smoking behavior. Using high-resolution structural magnetic resonance imaging, we therefore measured cortical thickness of the insula in 18 smokers and 24 nonsmokers between the ages of 16 and 21 years. There were no group differences in insula thickness, but cigarette exposure (packyears) was negatively associated with thickness in right insula. Cigarette dependence and the urge to smoke were negatively related to cortical thickness in the right ventral anterior insula. Although the results do not demonstrate causation, they do suggest that there are effects of cigarette exposure on brain structure in young smokers, with a relatively short smoking history. It is possible that changes in the brain due to prolonged exposure or to the progression of dependence lead to more extensive structural changes, manifested in the reported group differences between adult smokers and nonsmokers. Structural integrity of the insula may have implications for predicting long-term cigarette smoking and problems with other substance abuse in this population.

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High density of nicotinic receptors in the cingulo-insular network

Cited by 78 publications

References 77 publications

EEG Source Reconstruction in Male Nonsmokers after Nicotine Administration during the Resting State

EEG Source Reconstruction in Male Nonsmokers after Nicotine Administration during the Resting State

Reduced-Nicotine Cigarettes in Young Smokers: Impact of Nicotine Metabolism on Nicotine Dose Effects

Cigarette Exposure, Dependence, and Craving Are Related to Insula Thickness in Young Adult Smokers

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