High Density Lipoproteins Phosphatidylcholine as a Regulator of Reverse Cholesterol Transport

Torkhovskaya, T. I.; Kudinov, V.A.; Zakharova, T. S.; Ipatova, O. M.; Markin, S. S.

doi:10.1134/s1068162018060092

Cited by 6 publications

(2 citation statements)

References 72 publications

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“… Transport of free cholesterol from the plasmatic membrane to acceptor particles (HDL) by the participation of membrane-localized ATP-binding cassette transporters ABCA1 and ABCG1 [ 37 ]. A significant role in this process belongs to the main phospholipid (PL) of HDL, phosphatidylcholine [ 42 ]. Esterification of free cholesterol bound to HDL by LCAT.…”

Section: Functions Of Hdlmentioning

confidence: 99%

High-Density Lipoproteins as Homeostatic Nanoparticles of Blood Plasma

Kudinov

Alekseeva

Torkhovskaya

et al. 2020

IJMS

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It is well known that blood lipoproteins (LPs) are multimolecular complexes of lipids and proteins that play a crucial role in lipid transport. High-density lipoproteins (HDL) are a class of blood plasma LPs that mediate reverse cholesterol transport (RCT)—cholesterol transport from the peripheral tissues to the liver. Due to this ability to promote cholesterol uptake from cell membranes, HDL possess antiatherogenic properties. This function was first observed at the end of the 1970s to the beginning of the 1980s, resulting in high interest in this class of LPs. It was shown that HDL are the prevalent class of LPs in several types of living organisms (from fishes to monkeys) with high resistance to atherosclerosis and cardiovascular disorders. Lately, understanding of the mechanisms of the antiatherogenic properties of HDL has significantly expanded. Besides the contribution to RCT, HDL have been shown to modulate inflammatory processes, blood clotting, and vasomotor responses. These particles also possess antioxidant properties and contribute to immune reactions and intercellular signaling. Herein, we review data on the structure and mechanisms of the pleiotropic biological functions of HDL from the point of view of their evolutionary role and complex dynamic nature.

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Section: Functions Of Hdlmentioning

confidence: 99%

High-Density Lipoproteins as Homeostatic Nanoparticles of Blood Plasma

Kudinov

Alekseeva

Torkhovskaya

et al. 2020

IJMS

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“…Among the other lipid classes, PC-related species (i.e., PC, PC-O, and PC-P) in particular were positively correlated to HDL-C across the study population. As the key phospholipid instrumental for HDL assembly, an enrichment of PC in plasma promotes apolipoprotein A1 redistribution which enhances nascent HDL formation and thus, serum HDL-C concentrations ( 37 – 39 ). While the increases in PC were not group-specific, those characteristically raised with wolfberry intake trended toward species that had generally longer carbon chains.…”

Section: Discussionmentioning

confidence: 99%

Effects of wolfberry (Lycium barbarum) consumption on the human plasma lipidome and its association with cardiovascular disease risk factors: a randomized controlled trial of middle-aged and older adults

Toh,

Zhou,

Cazenave-Gassiot

et al. 2024

Front. Nutr.

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BackgroundLong-term wolfberry intake as part of a healthy dietary pattern was recognized to have beneficial vascular outcomes. Characterization of the plasma lipidome may further provide comprehensive insights into pathways underlying these cardiovascular protective effects.ObjectiveWe analyzed the plasma lipidome of subjects who adhered to a healthy dietary pattern either with or without wolfberry and investigated the associations between the plasma lipidomic profile and cardiovascular health-related indicators.MethodsIn this 16-week, parallel design, randomized controlled trial, middle-aged and older adults (n = 41) were provided dietary counseling and assigned to either consume or not consume 15 g of wolfberry daily. At baseline and post-intervention, plasma lipidomics was assayed, and its relationships with classical CVD risk factors, vascular health, oxidant burden, carotenoids status, body composition, and anthropometry were examined.ResultsFrom the plasma lipidome, 427 lipid species from 26 sub-classes were quantified. In the wolfberry and control groups, significant changes were prominent for 27 and 42 lipid species, respectively (P < 0.05 with > 0.2-fold change). Fold changes for seven lipid species were also markedly different between the two groups. Examining the relationships between the plasma lipidome and CVD-related risk factors, total cholesterol revealed a marked positive correlation with 13 ceramide species, while HDL-cholesterol which was notably increased with wolfberry consumption showed a positive correlation with 10 phosphatidylcholine species. Oxidant burden, as represented by plasma 8-isoprostanes, was also inversely associated with lipidomic triglycerides and ether-triglycerides (41 species) and directly associated with hexosylceramides (eight species) and sphingomyelins (six species). There were no differential associations with CVD risk detected between groups.ConclusionCharacteristic alterations to the plasma lipidome were observed with healthy dietary pattern adherence and wolfberry consumption. An examination of these fluctuations suggests potential biochemical mechanisms that may mediate the antioxidant and cardiovascular protective effects of healthy dietary pattern adherence and wolfberry intake. This study was registered at clinicaltrials.gov as NCT0353584.

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