High-density lipoproteins: a novel therapeutic target for cardiovascular disease

Saleem, TS Mohamed; Rani, PV Sandhya; Gauthaman, K

doi:10.2147/rrcc.s15600

Cited by 3 publications

(5 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High HDL independently exerts a beneficial effect on lowering cardiovascular disease risk [52]. In the present study, HDL levels decreased with green tea consumption (Figure 1) which is not a favorable action.…”

Section: Hdl Cholesterolcontrasting

confidence: 45%

Effect of Green Tea Consumption on Selected Metabolic Biomarkers in Asian Indian Women with Metabolic Syndrome

Ray¹,

Singhania²

2014

FNS

View full text Add to dashboard Cite

Evidence for benefits of anti-oxidative power of polyphenols in cardiovascular diseases has been established. In the present study, effect of polyphenol rich green tea on selected metabolic biomarkers among Asian Indian women with metabolic syndrome in normal free living condition has been recorded. Thirty three Asian Indian women (>30 y) confirmed as having metabolic syndrome, were enrolled for the present study based on written informed consent. Subjects were asked to consume three cups of green tea daily for a period of four months. Regular telephonic contact and periodic visit to supply the tea were made to ensure compliance with the intervention and maintenance of lifestyle and dietary pattern, as followed before the experimental period. Parameters analyzed at baseline have been used as control data to eliminate individual variation. Doubleblind analysis of selected metabolic markers was done at baseline, 2 months and 4 months of the intervention period. At four months, a significant reduction from baseline was observed in weight (2%), waist circumference (4.5%), blood sugar (4%), glycosylated hemoglobin (4%), total cholesterol (11%) and LDL cholesterol (13%) (p < 0.01). The effect of green tea consumption on BMI, fasting insulin, HDL cholesterol, triglyceride, VLDL, C-reactive protein and homocysteine levels was either inconsistent or non significant. The present study showed that green tea consumption by free living subjects with metabolic syndrome resulted in significant improvements in some of the cardiovascular risk factors including visceral fat, blood sugar and cholesterol level.

show abstract

Section: Hdl Cholesterolcontrasting

confidence: 45%

Effect of Green Tea Consumption on Selected Metabolic Biomarkers in Asian Indian Women with Metabolic Syndrome

Ray¹,

Singhania²

2014

FNS

View full text Add to dashboard Cite

show abstract

“…The biology of HDL is more complex than that of LDL, and capable of slowing atherosclerosis through several mechanisms. The number of regulators – genetic polymorphisms affecting synthesis of apoproteins, receptors, enzymes that remodel lipoproteins, and inflammatory markers that determine HDL-C levels, maturation, and function – are staggering, but multiple steps and regulators simultaneously provide additional therapeutic opportunities 364. Over 75 different proteins are found within HDL populations that are concerned with lipid metabolism, complement activation, acute phase response; and protease inhibition 365.…”

Section: Residual Risk Remains a Source Of Concernmentioning

confidence: 99%

“…The number of regulators – genetic polymorphisms affecting synthesis of apoproteins, receptors, enzymes that remodel lipoproteins, and inflammatory markers that determine HDL-C levels, maturation, and function – are staggering, but multiple steps and regulators simultaneously provide additional therapeutic opportunities. 364 Over 75 different proteins are found within HDL populations that are concerned with lipid metabolism, complement activation, acute phase response; and protease inhibition. 365 Within the total HDL-C weight, the subfractions function differently, each with a specific biological function 366 which is partly dependent upon the triglyceride level.…”

Section: Residual Risk Remains a Source Of Concernmentioning

confidence: 99%

“…Comprehensive discussions about HDL biogenesis, life cycle and function, are available elsewhere in greater detail. 364 , 382 , 403 – 406 , 421 – 425 …”

Section: Residual Risk Remains a Source Of Concernmentioning

confidence: 99%

“… 550 Among several potential applications of CIMT, appropriate use criteria rated seven as appropriate, 16 as uncertain, and 10 as inappropriate. 364 …”

Section: Residual Risk Remains a Source Of Concernmentioning

confidence: 99%

See 2 more Smart Citations

Primary prevention of coronary heart disease: integration of new data, evolving views, revised goals, and role of rosuvastatin in management. A comprehensive survey

Kones¹

2011

DDDT

214

154

View full text Add to dashboard Cite

A recent explosion in the amount of cardiovascular risk and incipient, undetected subclinical cardiovascular pathology has swept across the globe. Nearly 70% of adult Americans are overweight or obese; the prevalence of visceral obesity stands at 53% and continues to rise. At any one time, 55% of the population is on a weight-loss diet, and almost all fail. Fewer than 15% of adults or children exercise sufficiently, and over 60% engage in no vigorous activity. Among adults, 11%–13% have diabetes, 34% have hypertension, 36% have prehypertension, 36% have prediabetes, 12% have both prediabetes and prehypertension, and 15% of the population with either diabetes, hypertension, or dyslipidemia are undiagnosed. About one-third of the adult population, and 80% of the obese, have fatty livers. With 34% of children overweight or obese, prevalence having doubled in just a few years, type 2 diabetes, hypertension, dyslipidemia, and fatty livers in children are at their highest levels ever. Half of adults have at least one cardiovascular risk factor. Not even 1% of the population attains ideal cardiovascular health. Despite falling coronary death rates for decades, coronary heart disease (CHD) death rates in US women 35 to 54 years of age may now be increasing because of the obesity epidemic. Up to 65% of patients do not have their conventional risk biomarkers under control. Only 30% of high risk patients with CHD achieve aggressive low density lipoprotein (LDL) targets. Of those patients with multiple risk factors, fewer than 10% have all of them adequately controlled. Even when patients are titrated to evidence-based targets, about 70% of cardiac events remain unaddressed. Undertreatment is also common. About two-thirds of high risk primary care patients are not taking needed medications for dyslipidemia. Poor patient adherence, typically below 50%, adds further difficulty. Hence, after all such fractional reductions are multiplied, only a modest portion of total cardiovascular risk burden is actually being eliminated, and the full potential of risk reduction remains unrealized. Worldwide the situation is similar, with the prevalence of metabolic syndrome approaching 50%. Primordial prevention, resulting from healthful lifestyle habits that do not permit the appearance of risk factors, is the preferred method to lower cardiovascular risk. Lowering the prevalence of obesity is the most urgent matter, and is pleiotropic since it affects blood pressure, lipid profiles, glucose metabolism, inflammation, and atherothrombotic disease progression. Physical activity also improves several risk factors, with the additional potential to lower heart rate. Given the current obstacles, success of primordial prevention remains uncertain. At the same time, the consequences of delay and inaction will inevitably be disastrous, and the sense of urgency mounts. Since most CHD events arise in a large subpopulation of low- to moderate-risk individuals, identifying a high proportion of those who will go on to develop events with accuracy remains...

show abstract

Pathophysiology and inhibition of cholesteryl ester transfer protein for prevention of cardiovascular diseases: An update

Banerjee¹,

De²

2021

Drug Discovery Today

View full text Add to dashboard Cite

High-density lipoproteins: a novel therapeutic target for cardiovascular disease

Cited by 3 publications

References 41 publications

Effect of Green Tea Consumption on Selected Metabolic Biomarkers in Asian Indian Women with Metabolic Syndrome

Effect of Green Tea Consumption on Selected Metabolic Biomarkers in Asian Indian Women with Metabolic Syndrome

Primary prevention of coronary heart disease: integration of new data, evolving views, revised goals, and role of rosuvastatin in management. A comprehensive survey

Pathophysiology and inhibition of cholesteryl ester transfer protein for prevention of cardiovascular diseases: An update

Contact Info

Product

Resources

About