2003
DOI: 10.1161/01.atv.0000079011.67194.5a
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High-Density Lipoprotein Stimulates Endothelial Cell Migration and Survival Through Sphingosine 1-Phosphate and Its Receptors

Abstract: Objective-Plasma high-density lipoprotein (HDL) level is inversely correlated with the risk of atherosclerosis. However, the cellular mechanism by which HDL exerts antiatherogenic actions is not well understood. In this study, we focus on the lipid components of HDL as mediators of the lipoprotein-induced antiatherogenic actions. Methods and Results-HDL and sphingosine 1-phosphate (S1P) stimulated the migration and survival of human umbilical vein endothelial cells. These responses to HDL and S1P were almost c… Show more

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Cited by 218 publications
(176 citation statements)
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“…Oxidative stress and inflammation are common features of CKD and promote endothelial cell injury and apoptosis. Acting via its constituent ApoA-1 and sphingosine-1 phosphate (S1P) proteins, HDL lowers caspase-3 activity, inhibits the formation of ROS, and prevents apoptosis of endothelial cells [22][23][24] . In addition, normal HDL facilitates the repair, migration, and proliferation of endothelial cells and increases the number of circulating endothelial progenitor cells -events that are essential for vascular repair and prevention of plaque formation [25][26][27] ( FIG.…”
Section: Biologic Functions Of Normal Hdlmentioning
confidence: 99%
“…Oxidative stress and inflammation are common features of CKD and promote endothelial cell injury and apoptosis. Acting via its constituent ApoA-1 and sphingosine-1 phosphate (S1P) proteins, HDL lowers caspase-3 activity, inhibits the formation of ROS, and prevents apoptosis of endothelial cells [22][23][24] . In addition, normal HDL facilitates the repair, migration, and proliferation of endothelial cells and increases the number of circulating endothelial progenitor cells -events that are essential for vascular repair and prevention of plaque formation [25][26][27] ( FIG.…”
Section: Biologic Functions Of Normal Hdlmentioning
confidence: 99%
“…The cells were cultured in RPMI 1640 medium supplemented with 15% (v/v) FBS and several growth factors as previously described (25,26). We usually used 5-8 passage of the cells and checked the cobblestone-like cell shape before experiments.…”
Section: Cell Culture and Sirna Transfectionmentioning
confidence: 99%
“…It has been shown to stimulate endothelial cell (EC) proliferation and migration 6,7 and to recruit pericytes and SMCs to immature vessels so that they may proliferate, migrate, and differentiate to a more contractile phenotype. [8][9][10][11] Three of S1P's five receptors are expressed at high levels on ECs and SMCs: S1P 1 , S1P 2 , and S1P 3 (Fig.…”
Section: Introductionmentioning
confidence: 99%