High density lipoprotein inhibited group II innate lymphoid cells proliferation and function in allergic rhinitis

Abstract

Background More and more studies had suggested that dyslipidemia was closely related to allergic diseases. High density lipoprotein (HDL) often plays anti-inflammatory and anti-oxidative roles by suppressing immune cell chemotaxis and activation. We aimed to explore the role of HDL in the regulation of group II innate lymphoid cells (ILC2) in allergic rhinitis (AR). Methods The blood lipid levels and their correlation with symptom scores of 20 AR subjects and 20 controls were analyzed. Purified ILC2 were stimulated by HDL and cytokines production were examined by enzyme-linked immunosorbent assay (ELISA) and flow cytometry. The mRNA levels of GATA binding protein 3(GATA3) and retinoid-related orphan receptor α (RORα) expressed by ILC2 were detected using reverse transcription polymerase chain reaction (RT-PCR). Results HDL level was significantly lower in AR than controls and correlated with the symptom scores. The serum HDL levels were negatively related to the increased number of ILC2, IL-5+ ILC2, and IL-13+ ILC2 in AR patients. HDL decreased the number of ILC2 and type II cytokines levels significantly by inhibiting expression of GATA3 and RORα. Conclusions Our data provide preliminary evidence that HDL may play a negative role in ILC2 inflammation in AR, suggesting that HDL may serve as promising treatment target in AR.

IL‐4/IL‐13 pathway in nasal type 2 inflammation: The central role and targeted therapy

“…The cells and group 2 innate lymphoid cells (ILC2s) are crucial in the pathogenetic process of nasal type 2 inflammation, and it is well known that the frequency of these cells elevates significantly in the peripheral blood of patients with AR and CRSwNP [16][17][18]. Alarmins, mainly derived from epithelial cells during the inflammation, promote the differentiation of naive CD4-positive T cells into Th2 cells and activate ILC2s [19,20].…”

The relationship between lipid parameters and the course of allergic rhinitis in children

“…Increased low-density lipoproteins (LDL) and triglyceride (TG) levels have pro-inflammatory effects associated with increased tumor necrosis factor-α (TNF-α) and IL-6 expression [ 12 , 13 ], while high-density lipoproteins (HDL) exert anti-inflammatory properties via T-lymphocyte activation [ 7 ]. In adults with AR, HDL values inversely correlate with the group II innate lymphoid cells (ILC2) that initiate Th2-dependent allergic reactions following stimulation by inter alia TSLP [ 14 ].…”

Association between lipid-lowering drugs and allergic diseases: A Mendelian randomization study

“…For example, it has been shown that high levels of TG and LDL-C and low levels of HDL-C are associated with asthma, and AD is associated with lower levels of TG and LDL. 11 , 12 , 13 Considering these findings, the relationship between lipid-lowering drugs and allergic diseases has received considerable attention. Commonly prescribed lipid-lowering drugs, such as 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) inhibitors and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, play pivotal roles in managing dyslipidemia and reducing cardiovascular risk.…”