High-density lipoprotein cholesterol level as an independent protective factor against aggravation of acute pancreatitis: a case–control study
Qingqiang Ni,
Zetao Yu,
Peng Zhang
et al.
Abstract:Background and aimsAt present, evidence on the association between high-density lipoprotein cholesterol (HDL-C) levels and aggravation of acute pancreatitis (AP) is limited. This study aimed to investigate the relationship between the lowest HDL-C level during intensive care units (ICU) stay and AP aggravation and to determine the optimum cutoff lowest HDL-C level.MethodsPatients admitted to the ICU of the Shandong Provincial Hospital for AP from 2015 to 2021 were included. The lowest HDL-C level during ICU st… Show more
“…Regarding HDL-C, some researchers have pointed out that reduced HDL leads to a more severe systemic inflammatory response [ 34 ]. During inflammation, HDL-C binds to endotoxins, facilitating their removal from the body [ 35 , 36 ]. Zhang et al.…”
Background
The neutrophil to high-density lipoprotein cholesterol ratio (NHR) is independently associated with the severity of various diseases. However, its association with acute biliary pancreatitis (ABP) remains unknown.
Methods
This study included 1335 eligible patients diagnosed with ABP from April 2016 to December 2022. Patients were divided into low- and high-NHR level groups using an optimal cut-off value determined utilizing Youden’s index. Multivariate logistic regression analysis was used to investigate the correlation between NHR and ABP severity. Multivariate analysis-based limited restricted cubic spline (RCS) method was used to evaluate the nonlinear relationship between NHR and the risk of developing moderate or severe ABP.
Results
In this study, multivariate logistic regression analysis indicated an independent association between NHR and ABP severity (
p
< .001). The RCS analysis showed a linear correlation between NHR and the risk of developing moderate or severe ABP (P for non-linearity > 0.05), and increased NHR was found to be independently associated with a more severe form of the disease.
Conclusions
Our study suggests that NHR is a simple and practical independent indicator of disease severity, serving as a potential novel predictor for patients with ABP.
“…Regarding HDL-C, some researchers have pointed out that reduced HDL leads to a more severe systemic inflammatory response [ 34 ]. During inflammation, HDL-C binds to endotoxins, facilitating their removal from the body [ 35 , 36 ]. Zhang et al.…”
Background
The neutrophil to high-density lipoprotein cholesterol ratio (NHR) is independently associated with the severity of various diseases. However, its association with acute biliary pancreatitis (ABP) remains unknown.
Methods
This study included 1335 eligible patients diagnosed with ABP from April 2016 to December 2022. Patients were divided into low- and high-NHR level groups using an optimal cut-off value determined utilizing Youden’s index. Multivariate logistic regression analysis was used to investigate the correlation between NHR and ABP severity. Multivariate analysis-based limited restricted cubic spline (RCS) method was used to evaluate the nonlinear relationship between NHR and the risk of developing moderate or severe ABP.
Results
In this study, multivariate logistic regression analysis indicated an independent association between NHR and ABP severity (
p
< .001). The RCS analysis showed a linear correlation between NHR and the risk of developing moderate or severe ABP (P for non-linearity > 0.05), and increased NHR was found to be independently associated with a more severe form of the disease.
Conclusions
Our study suggests that NHR is a simple and practical independent indicator of disease severity, serving as a potential novel predictor for patients with ABP.
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