High Density Lipoprotein Cholesterol and Apoprotein A1 in Healthy Volunteers during Long-Term Moderate Alcohol Intake

Couzigou, P; Fleury, Benoît; Crockett, R; Rautou, J.J.; Blanchard, Pierre‐Yves; Lemoine, F; Richard-Molard, B.; Amouretti, M; Béraud, C

doi:10.1159/000176849

Cited by 22 publications

(6 citation statements)

References 15 publications

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“…However, plasma triacylglycerol was unaffected by the wine when the meal was followed by a 15 h fasting period. This finding is in accordance with some long-term feeding studies which have failed to find any effect of moderate regular alcohol consumption on fasting plasma triacylglycerols in normal subjects (Hartung et al 1983;Couzigou et al 1984;Crouse & Grundy, 1984;McConnell et al 1997). However, recent meta-analysis of thirty-five human intervention studies with >6 d of alcohol administration revealed that alcohol consumption increased plasma triacylglycerol (Rimm et al 1999).…”

Section: Plasma Triacylglycerolsupporting

confidence: 87%

Alcohol drinking and cardiac risk

Buemann¹,

Dyerberg²,

Astrup³

2002

NRR

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The present paper provides a comprehensive review of the literature pertaining to the impact of alcohol intake on cardiovascular disease. Both cross-sectional and prospective studies have disclosed a negative association between moderate intake of alcoholic beverages and cardiovascular disease. The relationship appears to be present for both wine, beer and spirits. Effects of alcohol itself and also the role of different cardioprotective substances in alcoholic beverages are discussed. Alcohol has been suggested to beneficially affect the blood lipid profile, as it increases plasma HDL-cholesterol level. Furthermore, it may inhibit thrombogenesis by reducing thromboxan formation and decreasing the plasma level of fibrinogen. However, high blood concentrations of alcohol may impair fibrinolysis by increasing plasma plasminogen activator inhibitor-1 level. This action could contribute to explaining the 'U'-shaped association between alcohol intake and cardiac events. Alcohol seems to promote abdominal fat distribution, but the importance of this effect in non-obese individuals is uncertain. Wine in particular, but also beer, contains polyphenols which act as antioxidants. Their action could maintain the integrity of the endothelial function by reducing the formation of superoxide. Moreover, these antioxidants may protect against LDL oxidation and modulate the macrophage attack on the endothelium. Although the cardio-protective effect of alcohol can hardly be addressed in healthy individuals by intervention studies with hard end points, there are many observational and experimental findings indicating that moderate alcohol drinking possesses properties preventive of cardiovascular disease.

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Section: Plasma Triacylglycerolsupporting

confidence: 87%

Alcohol drinking and cardiac risk

Buemann¹,

Dyerberg²,

Astrup³

2002

NRR

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“…Although the crossover dietary trial was carried out on a small number of normolipidaemic healthy subjects, it confirms the modifications in plasma concentrations of HDLcholesterol, apoAI and apoAII under the effect of moderate alcohol consumption. Indeed, many studies have observed an increase in these parameters, either in chronic alcoholic [2,22] or in healthy volunteer subjects [23][24][25][26]. These results confirm those of previous studies, which have shown that the response of apoAII to alcohol was higher than that of apoAI in intemperate [27] as well as in normal subjects who received 60 g per day of alcohol [28].…”

Section: Discussionsupporting

confidence: 88%

Moderate red wine consumption in healthy volunteers reduced plasma clearance of apolipoprotein AII

Gottrand

Béghin

Duhal

et al. 1999

Eur J Clin Investigation

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“…Table 1 outlines the characteristics of the 63 included studies, totalling 1686 participants (1049 men and 625 women; one study of 12 participants did not indicate sex) 2021 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 Thirty six of the 63 (57%) studies included only men, eight (12.7%) included only women, and 19 (30%) included both. Thirty six studies used a crossover design and 24 used a before and after design, whereas three were parallel arm controlled trials.…”

Section: Resultsmentioning

confidence: 99%

Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies

Brien

Ronksley

Turner

et al. 2011

BMJ

661

544

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Objective To systematically review interventional studies of the effects of alcohol consumption on 21 biological markers associated with risk of coronary heart disease in adults without known cardiovascular disease. Design Systematic review and meta-analysis. Study selection Two reviewers independently selected studies that examined adults without known cardiovascular disease and that compared fasting levels of specific biological markers associated with coronary heart disease after alcohol use with those after a period of no alcohol use (controls). 4690 articles were screened for eligibility, the full texts of 124 studies reviewed, and 63 relevant articles selected. Results Of 63 eligible studies, 44 on 13 biomarkers were meta-analysed in fixed or random effects models. Quality was assessed by sensitivity analysis of studies grouped by design. Analyses were stratified by type of beverage (wine, beer, spirits). Alcohol significantly increased levels of high density lipoprotein cholesterol (pooled mean difference 0.094 mmol/L, 95% confidence interval 0.064 to 0.123), apolipoprotein A1 (0.101 g/L, 0.073 to 0.129), and adiponectin (0.56 mg/L, 0.39 to 0.72). Alcohol showed a dose-response relation with high density lipoprotein cholesterol (test for trend P=0.013). Alcohol decreased fibrinogen levels (−0.20 g/L, −0.29 to −0.11) but did not affect triglyceride levels. Results were similar for crossover and before and after studies, and across beverage types. Conclusions Favourable changes in several cardiovascular biomarkers (higher levels of high density lipoprotein cholesterol and adiponectin and lower levels of fibrinogen) provide indirect pathophysiological support for a protective effect of moderate alcohol use on coronary heart disease. INTRODUCTIONModerate alcohol consumption (up to one drink a day for women and up to two for men) has been associated with a decreased risk for certain cardiovascular

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High Density Lipoprotein Cholesterol and Apoprotein A1 in Healthy Volunteers during Long-Term Moderate Alcohol Intake

Cited by 22 publications

References 15 publications

Alcohol drinking and cardiac risk

Alcohol drinking and cardiac risk

Moderate red wine consumption in healthy volunteers reduced plasma clearance of apolipoprotein AII

Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies

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