High-Density Lipoprotein as a Therapeutic Target

A randomized clinical trial of home-based exercise combined with a slight caloric restriction on obesity prevention among women

“…For the metabolic parameters analyzed in our study, the most striking difference between the groups was for HDL-cholesterol, with a two-fold elevation for the HB in comparison with controls after 1 year of follow-up. These results have been extensively described (Donnelly, et al, 2000; Durstine, et al, 2001; Leon and Sanchez, 2001) among obese and hypercholesterolemic subjects, and our findings confirmed this association for middle-aged non-obese and non-hypercholesterolemic women, an important finding since high HDL cholesterol is one of the few protective factors for cardiovascular disease (Alwaili, 2010; Singh et al, 2007). …”

Lifestyle changes and 14-year change in high-density lipoprotein cholesterol in a cohort of male physicians

“…In this study, the magnitude of HDL-C increase associated with weight loss, maintaining low BMI, maintaining moderate alcohol intake, or increasing alcohol intake varied between approximately 5 and 10%, corroborating previous studies that examined associations between these lifestyle factors and HDL-C (1-14). Unlike previous cross-sectional studies examining associations between exercise and HDL-C, these authors did not find an association between increases in physical activity and changes in HDL-C(1).…”

APOE*3Leiden.CETP transgenic mice as model for pharmaceutical treatment of the metabolic syndrome

“…Also the decrease in body weight with liraglutide is in agreement with human data [37]. Niacin decreases triglycerides and LDL-cholesterol [43,44], and is the most potent HDL increasing drug currently used in the clinic [45]. The relatively high doses of rosiglitazone in our study and commonly used in other experimental studies in literature might explain the stronger additional effects observed on plasma lipids (see also Supporting information).…”