High-density Hyaluronic Acid for the Treatment of HIV-related Facial Lipoatrophy

Pignatti, Marco; Pedone, Antonio; Baccarani, Alessio; Guaraldi, Giovanni; Orlando, Gabriella; Lombardi, M.; G, De Santis

doi:10.1007/s00266-011-9771-3

Cited by 14 publications

(19 citation statements)

References 23 publications

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“…Although limited to a small number of patients, our study confirms previous observations [10,11] regarding the excellent tolerance of cross-linked HA fillers and the absence of allergic reactions or product-related complications. Significant cosmetic improvement and improved quality of life were observed in the HIV-LA patients in the current study.…”

Section: Discussionsupporting

confidence: 78%

“…Cosmetic treatment of HIV-LA using cross-linked HA derivatives, collagen, L -polylactic acid and autologous fat has been reported [9,10,28]. HA is a polymer present in the extracellular matrix of the connective tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Nowadays HIV patients experience aging, which can also induce facial lipoatrophy. Therefore, the injection of facial fillers plays an important role as a complementary therapeutic option [10,24,28]. …”

Section: Discussionmentioning

confidence: 99%

“…Treatment strategies for HIV-associated facial lipoatrophy include soft tissue augmentation procedures performed using autologous fat grafting or injectable dermal fillers [8,9,10,11,12]. Cross-linked hyaluronic acid (HA) derivatives are non-permanent dermal fillers used not only for the correction of HIV-LA, but also for treatment of photodamaged skin [13], facial atrophic scars [14] and other cosmetic purposes [15,16,17].…”

Section: Introductionmentioning

confidence: 99%

“…Most authors assessed patient satisfaction by means of the Global Aesthetic Improvement Scale (GAIS) or the Quality of Life Assessment (QoLA) score [10,11], and only very few attempted to evaluate treatment results in a more objective manner by using ultrasonographic measurements of facial tissues [9,23]. Due to its excellent soft tissue discrimination and the possibility to obtain quantitative data, magnetic resonance imaging (MRI) is increasingly used for the evaluation of injectable dermal fillers [25].…”

Section: Introductionmentioning

confidence: 99%

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Hyaluronic Acid Filler in HIV-Associated Facial Lipoatrophy: Evaluation of Tissue Distribution and Morphology with MRI

et al. 2015

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Objective: This prospective observational study evaluated magnetic resonance imaging (MRI) findings of hyaluronic acid (HA) injections used for the correction of HIV-associated facial lipoatrophy. Methods: Ten consecutive males underwent subdermal HA injection (mean 1.3 ± 0.6 ml per side) and MRI examinations prior to and then 1, 6 and 12 months after injection. Two radiologists blinded to the clinical data assessed morphologic and quantitative changes. Results: MRI revealed HA deposition in the subdermal and deep fat compartments. A significant HA volume increase was observed 1 month after injection (mean increase 331%, p < 0.0001) as compared to the injected amount. No volume reduction occurred at 12 months (p = 0.9961). The measured bound water content did not change (p > 0.9991), whereas skin thickness and tissue vascularization increased during the first 6 months (p = 0.01). Conclusion: Our data show that the cosmetic results of HA injections are caused by water binding in the deep facial fat and by a transient increase in vascularization and skin thickness.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hyaluronic Acid Filler in HIV-Associated Facial Lipoatrophy: Evaluation of Tissue Distribution and Morphology with MRI

et al. 2015

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Controversies in Parotid Defect Reconstruction

Tamplen

Knott

Fritz

et al. 2016

Facial Plastic Surgery Clinics of North America

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A systematic review of filler agents for aesthetic treatment of HIV facial lipoatrophy (FLA)

Jagdeo

Ho²,

et al. 2015

Journal of the American Academy of Dermatology

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HIV facial lipoatrophy (FLA) is characterized by facial volume loss. HIV FLA affects the facial contours of the cheeks, temples, and orbits, and is associated with social stigma. Although new highly active antiretroviral therapy medications are associated with less severe FLA, the prevalence of HIV FLA among treated individuals exceeds 50%. The goal of our systematic review is to examine published clinical studies involving the use of filler agents for aesthetic treatment of HIV FLA and to provide evidence-based recommendations based on published efficacy and safety data. A systematic review of the published literature was performed on July 1, 2015, on filler agents for aesthetic treatment of HIV FLA. Based on published studies, poly-L-lactic acid is the only filler agent with grade of recommendation: B. Other reviewed filler agents received grade of recommendation: C or D. Poly-L-lactic acid may be best for treatment over temples and cheeks, whereas calcium hydroxylapatite, with a Food and Drug Administration indication of subdermal implantation, may be best used deeply over bone for focal enhancement. Additional long-term randomized controlled trials are necessary to elucidate the advantages and disadvantages of fillers that have different biophysical properties, in conjunction with cost-effectiveness analysis, for treatment of HIV FLA.

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High-density Hyaluronic Acid for the Treatment of HIV-related Facial Lipoatrophy

Abstract: Long-term improvement of facial contour and excellent patient satisfaction, in the absence of severe side effects, were obtained by the injection of high-density hyaluronic acid (STYLAGE® XL) in HIV patients with facial lipoatrophy.

Cited by 14 publications

References 23 publications

Hyaluronic Acid Filler in HIV-Associated Facial Lipoatrophy: Evaluation of Tissue Distribution and Morphology with MRI

Hyaluronic Acid Filler in HIV-Associated Facial Lipoatrophy: Evaluation of Tissue Distribution and Morphology with MRI

Controversies in Parotid Defect Reconstruction

A systematic review of filler agents for aesthetic treatment of HIV facial lipoatrophy (FLA)

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