High-density and low-density lipoproteins and prevalence of vascular disease in diabetes mellitus.

Reckless, J. P. D.; Betteridge, D. J.; Wu, Ping-Ping; Payne, B.; Galton, D. J.

doi:10.1136/bmj.1.6117.883

Cited by 109 publications

(29 citation statements)

References 18 publications

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“…Studies examining populations of diabetic subjects have also demonstrated the association of low HDL and HDL2 cholesterol levels with coronary heart disease [16,47,48]. In the present study sample known to have a high pre-R. W. Bergstrom et al: Triglyceride and C-peptide with heart disease valence of Type 2 diabetes and impaired glucose tolerance, both reduced HDL and HDL2 cholesterol levels and reduced apoprotein A~ were associated with the presence of coronary heart disease.…”

Section: Discussionsupporting

confidence: 58%

“…Insulin resistance is increased in obesity and with site-specific differences in body fat deposits, which are also characteristically associated with Type 2 diabetes and coronary heart disease [13,14]. Potentially atherogenic lipoprotein abnormalities are also frequently observed in Type 2 diabetes [1,2,[13][14][15][16][17]. Moreover, in populations with glucose intolerance, elevated triglyceride levels have been associated with the subsequent progression to Type 2 diabetes [18] and coronary heart disease mortality [19].…”

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confidence: 99%

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Association of plasma triglyceride and C-peptide with coronary heart disease in Japanese-American men with a high prevalence of glucose intolerance

et al. 1990

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Summary. In a community-based study of second-generation Japanese-American men known to have a high prevalence of both Type 2 (non-insulin-dependent) diabetes and impaired glucose tolerance, there was a highly significant association of coronary heart disease with glucose intolerance in a study sample of 219 men. Intra-abdominal cross sectional fat area determined by computed tomography was significantly elevated in men with coronary heart disease even after adjustment for glucose intolerance and body mass index (p = 0.026). Other differences that were significantly related to coronary heart disease after adjustment for glucose intolerance were lower high density lipoprotein cholesterol levels (p = 0.001), elevated total triglyceride and very low density lipoprotein triglyceride (p < 0.001), and elevated fasting insulin and C-peptide levels p = 0.001. When these variables were tested in a stepwise multiple logistic regression model, significant independent associations with coronary heart disease were found only for total triglyceride and fasting C-peptide after adjustment for glucose tolerance status. Variables identified to be associated with coronary heart disease were interpreted as representing or manifesting an insulin resistant state. Thus, insulin resistance may be the underlying risk factor aetiologically linking glucose intolerance with coronary heart disease.

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Section: Discussionsupporting

confidence: 58%

mentioning

confidence: 99%

Association of plasma triglyceride and C-peptide with coronary heart disease in Japanese-American men with a high prevalence of glucose intolerance

et al. 1990

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“…This latter finding may, of course, indicate poorer pre-existing metabolic control of diabetics with non-proliferative retinopathy. On the other hand, an association between serum triglyceride and cholesterol elevation and large vessel disease in diabetic subjects has been noted [20]. In non-diabetics the increased level of GLU has been associated with both coronary artery disease [19] and a response in the glucose tolerance test [12] in atherosclerotic persons.…”

Section: Discussionmentioning

confidence: 99%

?-N-acetylglucosaminidase and ?-glucuronidase activities in insulin-dependent diabetic subjects with retinopathy

et al. 1980

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“…Hyperlipidemia has been associated with human diabetes mellitus (1,2) and with animal models of experimental diabetes (3-5), and is characterized by elevations of plasma apo B-containing lipoproteins. The atherogenic potential of such proteins (6) is consistent with the fact that diabetes is considered a significant risk factor for complications arising from premature atherosclerosis (7).…”

Section: Introductionmentioning

confidence: 99%

Effects of nonketotic streptozotocin diabetes on apolipoprotein B synthesis and secretion by primary cultures of rat hepatocytes.

Sparks¹,

Sparks²,

Bolognino³

et al. 1988

J. Clin. Invest.

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The effects of hypoinsulinemic nonketotic streptozotocin diabetes on hepatic apo B synthesis and secretion was studied in primary cultures of rat hepatocytes. Diabetic rats were characterized by their significantly elevated serum glucose, apo B, and triglyceride levels, while serum insulin levels were less than a third of normal. Serum transaminase activities of diabetic rats were significantly elevated when compared with control rats, which was attributed to an increase in liver transaminase activity in diabetic rats. The pattern of enzyme activities of hepatocytes reflected that observed in livers of donor rats and the pattern was retained by primary cultures of hepatocytes over the culture period. Hepatocytes from diabetic rats secreted only one third of the apo B secreted by hepatocytes from control rats, which was determined by monoclonal immunoassay of rat total apo B. Decreases in secretion were confirmed by measurement of secretory [35S~methionine-labeled lipoprotein apo B radioactivity. The decreased apo B content of media of hepatocytes from diabetic rats was not due to increased apo B catabolism since hepatocytes from diabetic rats were shown to degrade less lipoprotein-apo B than hepatocytes from normal rats in control experiments. In addition, the apo B content of detergent-solubilized hepatocytes from diabetic rats was significantly less than that of hepatocytes from control rats. These results suggest that insulin is necessary for normal hepatic apo B synthesis and secretion and that the hyperlipidemia associated with hypoinsulinemia in vivo is primarily of intestinal origin.

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High-density and low-density lipoproteins and prevalence of vascular disease in diabetes mellitus.

Cited by 109 publications

References 18 publications

Association of plasma triglyceride and C-peptide with coronary heart disease in Japanese-American men with a high prevalence of glucose intolerance

Association of plasma triglyceride and C-peptide with coronary heart disease in Japanese-American men with a high prevalence of glucose intolerance

?-N-acetylglucosaminidase and ?-glucuronidase activities in insulin-dependent diabetic subjects with retinopathy

Effects of nonketotic streptozotocin diabetes on apolipoprotein B synthesis and secretion by primary cultures of rat hepatocytes.

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