High-definition optical coherence tomography imaging of melanocytic lesions: a pilot study

Boone, Marc; Norrenberg, Sarah; Jemec, Gregor B. E.; Marmol, Véronique Del

doi:10.1007/s00403-013-1387-9

Cited by 76 publications

(87 citation statements)

References 31 publications

(52 reference statements)

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“…5.2). Previous reviews of OCT focused on advanced screening in the fields of primary care, 53 microscopy, 54 rapid tissue screening, 55 phantoms, 56 high speed, 57 and translational research, 58 while recent application-specific OCT reviews covered ophthalmology, [59][60][61] cardiology, [62][63][64][65][66] dermatology, [67][68][69][70] novel applications in pulmonary medicine, 71 cancer, 72 and optical coherence elastography, 73 as well as OCT post-and signal processing. 74,75 This review focuses on high-speed technology (SS light technology and parallelization of OCT detection), label-free angiography, and multimodal OCT.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

418

264

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Abstract. In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times to more than 5 million A-scans per second, with the latter one accomplished by the state-of-the-art swept source laser technologies that are reviewed in this article. In addition, parallelization of OCT detection, such as line-field and full-field OCT, has shortened the acquisition time even further by establishing quasi-akinetic scanning. Besides the technical improvements, several functional and contrast-enhancing OCT applications have been investigated, among which the label-free angiography shows great potential for future studies. Finally, various multimodal imaging modalities with OCT incorporated are reviewed, in that these multimodal implementations can synergistically compensate for the fundamental limitations of OCT when it is used alone. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Introductionmentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

418

264

View full text Add to dashboard Cite

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“…Figure 3 depicts an OCT image of an area of increased dense collagen. Another type of OCT, known as high-definition OCT (HD-OCT), permits morphologic analysis of skin structures in 3 dimensions and can provide images of individual cells [2,3]. …”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography (OCT) of collagen in normal skin and skin fibrosis

et al. 2013

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Optical coherence tomography (OCT) is a non-invasive imaging modality that is transforming clinical diagnosis in dermatology and other medical fields. OCT provides a cross-sectional evaluation of the epidermis and dermis and allows in vivo imaging of skin collagen. Upregulated collagen content is a key feature of fibrotic skin diseases. These diseases are often managed by the practitioner’s subjective assessment of disease severity and response to therapies. The purpose of this review is to provide an overview of the principles of OCT and present available evidence on the ability of OCT to image skin collagen in vivo for the diagnosis and management of diseases characterized by skin fibrosis. We review OCT studies that characterize the collagen content in normal skin and fibrotic skin diseases including systemic sclerosis and hypertrophic scars secondary to burn, trauma, and other injury. We also highlight several limitations of OCT and suggest enhancements to improve OCT imaging of skin fibrosis. We conclude that OCT imaging has the potential to serve as an objective, non-invasive measure of collagen’s status and disease progression for use in both research trials and clinical practice. The future use of OCT imagining as a quantitative imaging biomarker of fibrosis will help identify fibrosis and facilitate clinical examination in monitoring response to treatment longitudinally without relying on serial biopsies. The use of OCT technology for quantification of fibrosis is in the formative stages and we foresee tremendous growth potential, similar to the ultrasound development paradigm that evolved over the past 30 years.

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“…These dots present a chaotic distribution compared with naevi [9]. With the increase in tumour thickness, the red dots tend to aggregate in apparently linear structures.…”

Section: Naevi and Melanomamentioning

confidence: 99%

“…A limited resolution and the lack of visualization of cellular structures have hitherto restricted the use of OCT in the evaluation and differentiation of naevi and malignant melanoma [8,9]. Recently, however, speckle variance OCT has been introduced and made commercially available.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Optical Coherence Tomography in Dermatology

Ulrich¹,

et al. 2016

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Optical coherence tomography (OCT) represents a non-invasive imaging technology, which may be applied to the diagnosis of non-melanoma skin cancer and which has recently been shown to improve the diagnostic accuracy of basal cell carcinoma. Technical developments of OCT continue to expand the applicability of OCT for different neoplastic and inflammatory skin diseases. Of these, dynamic OCT (D-OCT) based on speckle variance OCT is of special interest as it allows the in vivo evaluation of blood vessels and their distribution within specific lesions, providing additional functional information and consequently greater density of data. In an effort to assess the potential of D-OCT for future scientific and clinical studies, we have therefore reviewed the literature and preliminary unpublished data on the visualization of the microvasculature using D-OCT. Information on D-OCT in skin cancers including melanoma, as well as in a variety of other skin diseases, is presented in an atlas. Possible diagnostic features are suggested, although these require additional validation.

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High-definition optical coherence tomography imaging of melanocytic lesions: a pilot study

Cited by 76 publications

References 31 publications

Optical coherence tomography today: speed, contrast, and multimodality

Optical coherence tomography today: speed, contrast, and multimodality

Optical coherence tomography (OCT) of collagen in normal skin and skin fibrosis

Dynamic Optical Coherence Tomography in Dermatology

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