High‐definition blood flow imaging in the assessment of left ventricular function: Initial experience and comparison with contrast echocardiography

Wu, Geru; Xie, Tianrong; Dimaano, Meneleo; Alghrouz, Mohammad; Ahmad, Masood

doi:10.1111/echo.14282

Cited by 5 publications

(19 citation statements)

References 19 publications

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“…3 On the other hand, contrast use increases up-front cost, converts a completely non-invasive test to a semi-invasive test by requiring an intravenous line, involves additional time and personnel in injecting contrast, and is not without side effects. 5 suboptimal non-diagnostic study into a diagnostic test. 5,7 In 18 patients with suboptimal baseline echocardiograms, and referred for evaluation of LV function, both HDI and CE images were obtained during the same study.…”

Section: Discussionmentioning

confidence: 99%

“…Our HDI technique was recently published. 5 Briefly, HDI is a power Doppler based technique utilizing a short pulse width, programmable waveform pulse transmission, and multipoint interpolation. The proprietary software, available in the Hitachi scanner, applies several factors to optimize the waveform for a reduction in clutter and noise components.…”

Section: Me Thodsmentioning

confidence: 99%

“…As a result of our previous study, high-resolution blood flow images are created for improved definition of the LV endocardial border. 5 Upon completion of the study, cine loops of the HDI and CE were randomly assigned for analysis by two independent and experienced observers blinded to the patient's clinical and previous echocardiographic data. LV volumes and EF were calculated, using the biplane method of disks (modified Simpson's method).…”

Section: Me Thodsmentioning

confidence: 99%

“…We recently reported the feasibility and efficacy of High-definition blood flow Imaging (HDI) in the assessment of LV function and demonstrated the results were comparable to those obtained by contrast echocardiography (CE). 5 The present study was designed to further validate the HDI technique in measurements of LV volumes and EF by comparisons with CE and CMR.…”

Section: Introductionmentioning

confidence: 99%

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Validation of left ventricular volume and ejection fraction measurements by high‐definition blood flow imaging: Comparisons with cardiac magnetic resonance imaging and contrast echocardiography

Ahmad

Frank

et al. 2020

Echocardiography

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Background: We recently reported the efficacy of High-definition blood flow imaging (HDI) in the assessment of left ventricular (LV) function and demonstrated that the results are comparable to those obtained by contrast echocardiography (CE). The present study validates HDI in measurements of LV volumes and ejection fraction (EF) by simultaneous comparisons with CE and cardiac magnetic resonance imaging (CMR). Methods: Eighteen patients (age range 25-79 years) with limited echocardiographic images had measurements of LV end-diastolic volume (EDV, mL), end-systolic volume (ESV, mL), and EF (%) by HDI, CE, and CMR. Results: Using the three techniques, measurements of EDV, ESV, and EF correlated well with correlation coefficients (r) ranging from .91 to .98 in comparisons between HDI and CMR, and .89 to .97 in comparisons between CE and CMR. The limits of agreement for the inter-methods comparisons by Bland-Altman analysis (mean ± 1.96

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Section: Discussionmentioning

confidence: 99%

Section: Me Thodsmentioning

confidence: 99%

Section: Me Thodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Validation of left ventricular volume and ejection fraction measurements by high‐definition blood flow imaging: Comparisons with cardiac magnetic resonance imaging and contrast echocardiography

Ahmad

Frank

et al. 2020

Echocardiography

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“…[1][2][3] Left ventricular (LV) hemodynamics provide a new perspective for the understanding of cardiovascular physiology, clinical diagnostics, and prognostic information. 4 The assessment of blood flow in LV during different phases of the cardiac cycle is related to characteristics of the cardiac function. 5 Characteristics of LV vortices were investigated during the cardiac cycle.…”

Section: Introductionmentioning

confidence: 99%

Validation of Echodynamography in Comparison with Particle-image Velocimetry

et al. 2019

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Echodynamography (EDG) is a computational method to estimate and visualize two-dimensional flow velocity vectors by applying dynamic flow theories to color Doppler echocardiography. The EDG method must be validated if applied to human cardiac flow function. However, a few studies of flow estimated have compared by EDG to the flow data were acquired by other methods. In this study, EDG was validated by comparing the analysis of estimating and visualizing flow velocity vectors obtained by original particle image velocimetry (PIV) based on a left ventricular (LV) phantom hydrogel (in vitro studies) and by EDG based on the virtual Doppler velocity. Velocity measured by PIV method and velocity estimated by EDG method in the perpendicular direction and the radial direction were compared. Regression analysis for the velocity estimated in the radial direction revealed an excellent correlation ([Formula: see text], slope = 0.96) and moderate correlation in the perpendicular direction ([Formula: see text], slope = 0.46). As revealed by the Bland–Altman plot, however, overestimations and higher relative error were observed in the perpendicular direction (0.51 ± 2.75 mm/s) and in the radial direction (–2.15 ± 21.13 mm/s). The percentage error of the norm-wise relative error of the velocity discrepancy is less than [Formula: see text], and velocity magnitude followed the same trends and are of comparable magnitude. These findings indicate that good estimates of velocity can be obtained by the EDG method. Therefore, the EDG method was appropriate for estimating and visualizing velocity vectors in clinical studies for higher measurement accuracy and reliability. The clinical in vivo application showed that the EDG method has the ability to visualize blood flow velocity vectors and differentiate the clinical information of vortex parameters both in normal and abnormal LV subjects. In conclusion, the EDG method has potentially greater clinical acceptance as a tool assessment of LV during the cardiac cycle.

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High-definition blood flow imaging improves quantification of left ventricular volumes and ejection fraction

Gama,

Custódio,

Tsagkridi

et al. 2023

European Heart Journal - Cardiovascular Imaging

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Aims The accuracy and reproducibility of echocardiography to quantify left ventricular ejection fraction (LVEF) is limited due to image quality. High-definition blood flow imaging is a new technique which improves cavity delineation without the need for medication or intravenous access. We sought to examine the impact of high-definition blood flow imaging on accuracy and reproducibility of LV systolic function assessment. Methods and results Prospective observational study of consecutive patients undergoing 2D and 3D transthoracic echocardiography (TTE), high-definition blood flow imaging, and cardiac magnetic resonance (CMR) within 1 h of each other. Left ventricular systolic function characterized by left ventricular end-systolic volumes and left ventricular end-diastolic volumes and LVEF were measured. Seventy-six patients were included. Correlation of 2D TTE with CMR was modest (r = 0.68) with a worse correlation in patients with three or more segments not visualized (r = 0.58). High-definition blood flow imaging was feasible in all patients, and the correlation of LVEF with CMR was excellent (r = 0.88). The differences between 2D, high-definition blood flow, and 3D TTE compared to CMR were 5 ± 9%, 2 ± 5%, and 1 ± 3%, respectively. The proportion of patients where the grade of LV function was correctly classified improved from 72.3% using 2D TTE to 92.8% using high-definition blood flow imaging. 3D TTE also had excellent correlation with CMR (r = 0.97) however was only feasible in 72.4% of patients. Conclusion High-definition blood flow imaging is highly feasible and significantly improves the diagnostic accuracy and grading of LV function compared to 2D echocardiography.

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High‐definition blood flow imaging in the assessment of left ventricular function: Initial experience and comparison with contrast echocardiography

Cited by 5 publications

References 19 publications

Validation of left ventricular volume and ejection fraction measurements by high‐definition blood flow imaging: Comparisons with cardiac magnetic resonance imaging and contrast echocardiography

Validation of left ventricular volume and ejection fraction measurements by high‐definition blood flow imaging: Comparisons with cardiac magnetic resonance imaging and contrast echocardiography

Validation of Echodynamography in Comparison with Particle-image Velocimetry

High-definition blood flow imaging improves quantification of left ventricular volumes and ejection fraction

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