High defense system expression broadens protection range at the cost of increased autoimmunity
Nitzan Aframian,
Shira Omer Bendori,
Tal Hen
et al.
Abstract:The evolutionary arms race between bacteria and their phage viruses has given rise to elaborate anti-phage defense mechanisms. Major advances have been made in revealing the molecular details underlying diverse defense systems, but general principles and constraints are largely unkown. Defense systems are often tested against a diverse set of phages, revealing widely varying protection ranges. While these disparities are usually attributed to differences in mechanism, here we show that increasing expression of… Show more
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