High dairy protein intake is associated with greater bone strength parameters at the distal radius and tibia in older men: a cross-sectional study

Langsetmo, Lisa; Shikany, James M.; Burghardt, Andrew J.; Cawthon, Peggy M.; Orwoll, Eric S.; Cauley, Jane A.; Taylor, Brent C; Schousboe, John T.; Bauer, Douglas C.; Vo, Tien; Ensrud, Kristine E.

doi:10.1007/s00198-017-4261-3

Cited by 28 publications

(23 citation statements)

References 27 publications

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“…Two cross-sectional large studies among 746 postmenopausal women (mean age 65 years) and 1016 older men (mean age 84 years), in Europe and USA respectively, were concordant in finding a positive association between the higher intake of animal-based and dairy protein (analyzed as a subgroup of animal-based sources) and outcomes of bone health (strength, microstructure and failure load). The studies did not find a significant association between plant-based proteins and outcomes of bone health [81,82].…”

Section: Bones (12 Studies)mentioning

confidence: 86%

The Effects of Cow-Milk Protein Supplementation in Elderly Population: Systematic Review and Narrative Synthesis

et al. 2020

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Background. To review currently available evidence on the effect of cow-milk proteins supplementation (CPS) on health in the elderly. Methods. Five electronic databases (Pubmed, Web of Science, Embase, Cochrane Library, ClinicalTrials.gov) were searched for studies about CPS among older people. All types of publications were included, with the exception of systematic reviews, meta-analyses, opinion letters, editorials, case reports, conference abstracts and comments. An additional search in Google Scholar and a manual review of the reference lists were performed. Results. Overall, 103 studies were included. Several studies explored the role of CPS in the preservation or improvement of muscle mass among healthy subjects (40 studies) and pre-frail, frail or sarcopenic patients (14), with evidence of beneficial effects. Other studies assessed the effect of CPS on bones (12), cardiovascular disease (8), inflamm-aging (7), chronic pulmonary disease (4), neurocognitive function (4), and vaccines (2), with weak evidence of positive effects. Seven studies in the field of protein metabolism investigated the role of CPS as an important contributor to nutritional needs. Other investigational areas are considered in the last five studies. Conclusions. The beneficial effects of CPS in achieving aged-related nutritional goals, in preserving muscle mass and in recovering after hospitalization may be particularly relevant in the elderly.

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Section: Bones (12 Studies)mentioning

confidence: 86%

The Effects of Cow-Milk Protein Supplementation in Elderly Population: Systematic Review and Narrative Synthesis

et al. 2020

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“…There was a positive association between animal and dairy protein intake with predicted bone failure load (calculated as: force for which 2% of the bone would be loaded beyond 0.7% strain [83]) and stiffness of the distal radius and tibia, which was largely attributed to observed changes in the trabecular bone microstructures. A separate cross-sectional study using dietary intake questionnaire data from >1000 older males from the Osteoporotic Fractures in Men Study, showed positive associations between animal protein intake and bone strength [25]. The findings of each of these studies indicate beneficial effects of animal protein sources on bone strength in older adults.…”

Section: Bonementioning

confidence: 89%

“…Moreover, in the western population, there is an apparent shift towards increased consumption of plant-derived protein (in lieu of animal), due to perceived health benefits (e.g., reduced cardiovascular mortality [22]) and environmental sustainability [6]. Reflecting this shift, while the majority of prior research investigations have focused upon characterising the effects of animal-derived proteins in relation to musculoskeletal metabolism and health, there has been a recent surge of studies investigating the influence of plant-derived (e.g., References [4,[23][24][25]), collagen-derived (e.g., References [26][27][28][29]) and blended (e.g., References [30][31][32]) protein sources.…”

Section: Dietary Protein Requirementsmentioning

confidence: 99%

Animal, Plant, Collagen and Blended Dietary Proteins: Effects on Musculoskeletal Outcomes

et al. 2020

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Dietary protein is critical for the maintenance of musculoskeletal health, whereappropriate intake (i.e., source, dose, timing) can mitigate declines in muscle and bone mass and/orfunction. Animal-derived protein is a potent anabolic source due to rapid digestion and absorptionkinetics stimulating robust increases in muscle protein synthesis and promoting bone accretion andmaintenance. However, global concerns surrounding environmental sustainability has led to anincreasing interest in plant- and collagen-derived protein as alternative or adjunct dietary sources.This is despite the lower anabolic profile of plant and collagen protein due to the inferior essentialamino acid profile (e.g., lower leucine content) and subordinate digestibility (versus animal). Thisreview evaluates the efficacy of animal-, plant- and collagen-derived proteins in isolation, and asprotein blends, for augmenting muscle and bone metabolism and health in the context of ageing,exercise and energy restriction.

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“…Calcium and vitamin D are the first-line supplementation for at-risk individuals as well as individuals with dietary deficiencies. Protein consumption has also been evaluated in increasing bone strength; Langsetmo et al 49 showed a positive association between dairy protein intake and skeletal health. Regular exercise involving resistance training and high-impact exercises employed early and often can contribute to elevated peak bone mass throughout life.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Malnutrition on 30-Day Postoperative Complications following Surgical Fixation of Distal Radius Fractures

Newman

Coste

Dua

et al. 2020

Journal of Hand and Microsurgery

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Introduction Distal radius fractures (DRFs) are increasingly managed surgically among fragility fractures due to prolonged life expectancy and surgical advancements. Yet, malnutrition can impact postoperative outcomes and complications. We sought to determine the impact of malnutrition on open reduction and internal fixation (ORIF) of DRFs during the perioperative and 30-day postoperative periods. Materials and Methods Using the National Surgical Quality Improvement Program database, all patients who underwent ORIF of a DRF between January 1, 2008, and December 31, 2016, were identified and stratified by preoperative serum albumin levels: normal (≥3.5 g/dL; n = 2,546) or hypoalbuminemia (<3.5 g/dL; n = 439). Demographical and perioperative data were compared. Operative complications were stratified into major and minor complications, and data were analyzed using descriptive statistics and multivariate regression models. Results Compared with patients with normal levels, a higher proportion of hypoalbuminemia patients had ASA scores > 3 (9.1 vs. 2%) and a longer mean length of stay (3.16 vs. 0.83 days). Hypoalbuminemia patients also had 625% greater odds for developing major complications during the 30-day postoperative period (odds ratio = 7.25; 95% confidence interval: 1.91–27.49). Conclusion Malnutrition significantly affected outcomes and complications of distal radius ORIF. This study highlights the importance of prevention and treatment of malnutrition in the setting of fragility fractures.

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High dairy protein intake is associated with greater bone strength parameters at the distal radius and tibia in older men: a cross-sectional study

Abstract: The association between protein intake and bone strength varied by source of protein. These results support a link between dairy protein intake and skeletal health, but an intervention study is needed to evaluate causality.

Cited by 28 publications

References 27 publications

The Effects of Cow-Milk Protein Supplementation in Elderly Population: Systematic Review and Narrative Synthesis

The Effects of Cow-Milk Protein Supplementation in Elderly Population: Systematic Review and Narrative Synthesis

Animal, Plant, Collagen and Blended Dietary Proteins: Effects on Musculoskeletal Outcomes

The Impact of Malnutrition on 30-Day Postoperative Complications following Surgical Fixation of Distal Radius Fractures

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