High cyclin A expression, but not Ki67, is associated with early recurrence in desmoid tumors

Santti, Kirsi; Ihalainen, Hanna; Rönty, Mikko; Böhling, Tom; Karlsson, Christina; Haglund, Caj; Tarkkanen, Maija; Blomqvist, Carl

doi:10.1002/jso.25121

Cited by 6 publications

(10 citation statements)

References 33 publications

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“…The biological rationale for an association between high ERβ and high risk of recurrence may be the positive correlation between ERβ and proliferation found in the present study. Our previous observation was that high proliferation is associated with a higher recurrence risk . We found no indication of a linear association between cyclin D1 expression and TTR, although cyclin D1 expression was also associated with higher proliferation rate measured by the expression of Ki67 and cyclin A.…”

Section: Discussioncontrasting

confidence: 72%

“…Our previous observation was that high proliferation is associated with a higher recurrence risk. 14 Despite the documented hormonal dependence of desmoid tumors, expression of ERα has been negative in the vast majority of studies. 3,15 An earlier report suggested that ERα antibody crosslinkage with ERβ may have elicited a few positive ERα findings.…”

Section: Discussionmentioning

confidence: 99%

“…If multiple scores with over 500 cells were recognized for one patient, the highest score was accepted. Expression of ERβ and cyclin D1 was scored with an image analysis software, as previously prescribed for the proliferation antigens Ki67 and cyclin A . Cut‐offs for positive expression was set at 1% for ERβ and both at 5% and at 10% for cyclin D1 (Figure ).…”

Section: Methodsmentioning

confidence: 99%

“…Cut‐offs for positive expression was set at 1% for ERβ and both at 5% and at 10% for cyclin D1 (Figure ). Ki67 and cyclin A expression were examined in our previous study …”

Section: Methodsmentioning

confidence: 99%

“…The tissue microarray (TMA) and immunohistochemical procedures are described in our previous work . Briefly, the TMA was constructed of formalin‐fixed paraffin‐embedded desmoid tumor tissue specimen.…”

Section: Methodsmentioning

confidence: 99%

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Estrogen receptor beta expression correlates with proliferation in desmoid tumors

Santti

Ihalainen

Rönty

et al. 2019

Journal of Surgical Oncology

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Background and objectives Estrogen receptor signaling and cyclin D1 have a major role in tumor cell proliferation in breast cancer. Desmoid tumors are rare neoplasms that may respond to endocrine treatment. The present study aimed to investigate the expression levels and the clinical relevance of estrogen receptor beta (ERβ) and cyclin D1 in desmoid tumors. Methods This study consists of 83 patients with a surgically treated desmoid tumor. ERβ and cyclin D1 expression was examined by immunohistochemistry in tissue microarrays. Cyclin A and Ki67 were studied in our previous work. Results Median ERβ expression was 10.8%. ERβ expression correlated with expression of the proliferation antigens Ki67 (rp = 0.35, P = 0.003), cyclin D1 (rp = 0.34, P = 0.004), and cyclin A (rp = 0.34, P = 0.004). ERβ immunoexpression showed a trend towards predictive impact for recurrence as a continuous variable. Further explorative analysis indicated that very high ERβ expression was related to high risk of relapse (hazard ratio [HR] 2.6; P = 0.02).Median cyclin D1 expression was 15.6%. High cyclin D1 expression was associated with high Ki67 and cyclin A expression. Cyclin D1 was not associated with time to recurrence. Conclusions ERβ and cyclin D1 immunopositivity correlated with high proliferation in desmoid tumors. High ERβ expression might be predictive for postoperative recurrence.

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Section: Discussioncontrasting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Cut‐offs for positive expression was set at 1% for ERβ and both at 5% and at 10% for cyclin D1 (Figure ). Ki67 and cyclin A expression were examined in our previous study …”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Estrogen receptor beta expression correlates with proliferation in desmoid tumors

Santti

Ihalainen

Rönty

et al. 2019

Journal of Surgical Oncology

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PARP-1 expression as a prognostic factor in Desmoid-type fibromatosis

Bräutigam

Lindner

Budczies

et al. 2020

Annals of Diagnostic Pathology

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Sporadic intra-abdominal desmoid tumor with a very unusual onset: two case reports

et al. 2021

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Background Intra-abdominal desmoid tumors are rare soft tissue tumors that arise mainly in the mesentery and pelvis. Their etiology may include genetic mutations, estrogen-associated changes after childbirth, and mechanical factors such as a history of abdominal surgery. However, there are cases of intra-abdominal desmoid tumors that develop in the absence of such causes. Since they are rare, diagnosis is often difficult based on clinical findings. We encountered two cases of patients with sporadic intra-abdominal desmoid tumors with a very unusual onset and contrasting features. Case presentation The first patient was a 51-year-old asian man who presented with sudden onset of abdominal pain. He was referred to our department because of a giant tumor detected on abdominal ultrasonography. Imaging revealed a 19-cm tumor with internal tumoral hemorrhage; however, no definitive diagnosis was made. Tumor resection was performed for diagnostic and therapeutic purposes. The second patient was a 41-year-old asian man, and right hydronephrosis was detected on abdominal ultrasonography during a periodic medical checkup. We diagnosed invasion of the primary mesenteric tumor into the right ureter using diagnostic imaging and performed ileocecal resection with partial right ureteral resection for a definitive diagnosis and therapeutic purposes. Although the tumors of both patients had developed from the ileal mesentery, the tumors were substantially different from each other based on their imaging findings, macroscopic morphology, and progression pattern. Meanwhile, they showed similar pathological characteristics. Both consisted of bundles of collagen fibrils of spindle-shaped fibroblasts with low cell atypia. Moreover, they were diagnosed as desmoid tumors using positive immunohistochemical staining for β-catenin. Conclusions Neither patient had susceptibility factors for desmoid tumors, and to our knowledge, there have been very few reports to date of intra-abdominal desmoid tumors that were diagnosed because of acute abdominal pain caused by tumoral hemorrhage or asymptomatic obstructive uropathy. Furthermore, it is clinically interesting that the two patients showed contrasting progression patterns and imaging findings. Intra-abdominal desmoid tumors are rare and may present with various symptoms and findings similar to those observed in our patients. Diagnosis therefore requires experience and knowledge that is not bound by preconceptions.

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High cyclin A expression, but not Ki67, is associated with early recurrence in desmoid tumors

Abstract: Our study indicates that cyclin A may be a new prognostic biomarker in surgically treated desmoid tumors.

Cited by 6 publications

References 33 publications

Estrogen receptor beta expression correlates with proliferation in desmoid tumors

Estrogen receptor beta expression correlates with proliferation in desmoid tumors

PARP-1 expression as a prognostic factor in Desmoid-type fibromatosis

Sporadic intra-abdominal desmoid tumor with a very unusual onset: two case reports

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