High cut-off membrane: evaluation of pore collapse and the synergistic effect of low and high molecular weight polyvinylpyrrolidone

Dehghan, Rahim; Barzin, Jalal

doi:10.1007/s10965-021-02429-w

Cited by 7 publications

(3 citation statements)

References 69 publications

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“…It has excellent small molecular toxin removal ability, but the removal rate of medium molecular toxins is not ideal 12 . To improve the removal of medium molecular molecules, Dehghan et al 13 explored the effect of different molecular weight polyvinylpyrrolidone (PVP) to achieve a high cut‐off (HCO) membrane in cooperation. HCO membranes can significantly improve the removal of middle molecular toxins, but there is a problem of high albumin loss 14,15 .…”

Section: Introductionmentioning

confidence: 99%

“…Chitosan (CS) is a natural polymer widely used in biomedicine, with good biocompatibility, nontoxicity and biodegradability 46–49 . Polyvinylpyrrolidone (PVP) is a polymer additive with excellent blood compatibility, biocompatibility and hydrophilicity that can increase membrane porosity and is a suitable choice for biomedical applications such as hemodialysis 13,50,51 . The addition of CS and PVP to the PA6 solution can improve the conductivity of the solution and reduce the binding energy of PA6, thereby providing the conditions for the formation of tree‐like structures 30,52 .…”

Section: Introductionmentioning

confidence: 99%

“…[46][47][48][49] Polyvinylpyrrolidone (PVP) is a polymer additive with excellent blood compatibility, biocompatibility and hydrophilicity that can increase membrane porosity and is a suitable choice for biomedical applications such as hemodialysis. 13,50,51 The addition of CS and PVP to the PA6 solution can improve the conductivity of the solution and reduce the binding energy of PA6, thereby providing the conditions for the formation of tree-like structures. 30,52 Combined with the strategy of electrospinning, the three materials can be easily compounded to prepare a PA6/PVP/CS nanofibrous membrane with a tree-like structure in one step.…”

Section: Introductionmentioning

confidence: 99%

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Tree‐like PA6/PVP/CS hemodialysis membrane to improve the contradiction between medium molecular toxins and proteins

Wang

Shao

et al. 2023

J of Applied Polymer Sci

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The contradiction between sufficient removal of middle molecular toxins and the retention of beneficial proteins is a great challenge for hemodialysis. The tree‐like structure was introduced to prepare a tree‐like PA6/PVP/CS nanofibrous membrane, which has good performance in the effective removal of middle molecular toxins and retention of beneficial proteins. The removal rates of urea and lysozyme were 75.4% and 46.3%, respectively, and the retention rate of bovine serum albumin (BSA) was 90.3%, which were 9%, 13%, and 18% higher than that of the membrane without tree‐like structure. In addition, to explore the possibility of further optimization of the tree‐like hemodialysis membrane, AC was added to prepare a tree‐like PA6/PVP/CS@AC nanofibrous membrane, which the urea removal rate was increased to 83.9%. The introduction of a tree‐like structure provides an effective way to solve the problem of protein loss and has great application potential in hemodialysis.

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Section: Introductionmentioning

confidence: 99%