High correlation between salivary MHPG and CSF MHPG

Reuster, Thomas; Rilke, Olaf; Oehler, Jochen

doi:10.1007/s00213-002-1125-z

Cited by 32 publications

(23 citation statements)

References 9 publications

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“…Even with an overall highly significant relation between CSF and salivary MHPG, quantitative assessments must be related to central noradrenaline turnover on an individual basis. However, with this reservation, the method did appear to be adequately reliable to us as a semiquantitative procedure and with sample sizes 420 (Reuster et al, 2002). Our results allow us to conclude that among patients with a still relatively recent onset of Korsakoff's syndrome, reboxetine dosing can contribute to improvements in cognitive performance.…”

Section: Discussionmentioning

confidence: 74%

“…We refrained from performing a lumbar puncture on most of the patients in our care for ethical and legal reasons, but in another study we were able to show that a highly significant correlation exists between MHPG in saliva and the CSF (r ¼ 0.76, po0.001, n ¼ 21) (Reuster et al, 2002). For this reason, we determined MHPG from a small salivary sample, which was obtained using a Sarstedt Salivette s .…”

Section: Drug Administration and Investigation Proceduresmentioning

confidence: 99%

See 1 more Smart Citation

Influence of Reboxetine on Salivary MHPG Concentration and Cognitive Symptoms Among Patients with Alcohol-Related Korsakoff's Syndrome

Reuster

Buechler

Winiecki

et al. 2002

Neuropsychopharmacol

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Section: Discussionmentioning

confidence: 74%

Section: Drug Administration and Investigation Proceduresmentioning

confidence: 99%

Influence of Reboxetine on Salivary MHPG Concentration and Cognitive Symptoms Among Patients with Alcohol-Related Korsakoff's Syndrome

Reuster

Buechler

Winiecki

et al. 2002

Neuropsychopharmacol

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“…According to Drebing et al (11), the saliva level of MHPG correlates significantly with the plasma level of MHPG, and it can be a useful and noninvasive tool for detecting changes in central norepinephrine metabolism. In addition, recent research has shown a high correlation between the MHPG in saliva and that in cerebrospinal fluid (12). We used the saliva MHPG concentration as an index of an activated central sympathetic nervous system.…”

Section: Discussionmentioning

confidence: 99%

Dependence of palmar sweating response and central nervous system activity on the frequency of whole-body vibration

Ando¹,

Noguchi²

2003

Scand J Work Environ Health

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“…The cerebrospinal fluid (CSF) concentrations of the dopamine, serotonin, and to a lesser degree norepinephrine metabolites, homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglycol (MHPG), respectively, are presumed to reflect the turnover of parent neurotransmitters in the central nervous system (Moir et al, 1970;Bowers, 1972;Stanley et al, 1985;Sharma et al, 1994;Reuster et al, 2002). Accordingly, measurements of these compounds in lumbar CSF have been employed in studies of brain function in vivo.…”

Section: Introductionmentioning

confidence: 99%

Lower CSF Homovanillic Acid Levels in Depressed Patients with a History of Alcoholism

Sher

Oquendo

et al. 2003

Neuropsychopharmacol

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Major depression and alcoholism are often comorbid, resulting in more impairment and more suicidal behavior compared with either diagnosis alone. This study compared clinical features and cerebrospinal fluid (CSF) monoamine metabolites in depressed subjects with and without a history of alcoholism and healthy volunteers. We hypothesized that depressed subjects with a history of alcoholism would be more aggressive, impulsive, and suicidal than depressed subjects without a history of alcoholism, and would have lower CSF monoamine metabolite levels. We compared 63 subjects with a current major depressive episode (MDE) and a history of alcoholism, 72 subjects with a current MDE but without a history of alcoholism, and 22 healthy volunteers. Participants with a history of alcoholism were in remission for at least 6 months. All subjects were free from prescribed medications known to affect brain serotonin, dopamine, or norepinephrine systems for a minimum of 14 days. Depressive symptoms, lifetime aggression, impulsivity, Axis II disorders, and suicidal behavior were assessed. CSF was sampled and homovanillic acid (HVA), 5-hydroxyindolacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) were assayed by high-performance lipid chromatography with electrochemical detection. Depressed subjects with a history of alcoholism did not differ from depressed subjects without a history of alcoholism in current severity of depressive symptoms, or in past suicidal behavior. Depressed subjects with a history of alcoholism had lower CSF HVA levels, and higher lifetime aggression and current suicide ideation scale scores and were more likely to be tobacco smokers compared with depressed subjects without a history of alcoholism. Low HVA was present after adjustment for sex, aggression and depression scores, cigarette smoking, antisocial and borderline personality disorders, psychomotor retardation, and delusions. Controls had CSF HVA levels intermediate between the two depressed groups. We found no group difference in CSF 5-HIAA and MHPG levels. In individuals with current MDE, those with a history of comorbid alcoholism had lower CSF HVA levels compared with those without a history of alcoholism. Low CSF HVA suggests that impaired dopaminergic activity is associated with a history of alcoholism in persons with current MDE.

show abstract

High correlation between salivary MHPG and CSF MHPG

Abstract: This finding supports the use of salivary MHPG as an index for CSF MHPG, and enhances the usefulness of salivary MHPG measurements as a non-invasive approach for clinical studies investigating noradrenergic systems.

Cited by 32 publications

References 9 publications

Influence of Reboxetine on Salivary MHPG Concentration and Cognitive Symptoms Among Patients with Alcohol-Related Korsakoff's Syndrome

Influence of Reboxetine on Salivary MHPG Concentration and Cognitive Symptoms Among Patients with Alcohol-Related Korsakoff's Syndrome

Dependence of palmar sweating response and central nervous system activity on the frequency of whole-body vibration

Lower CSF Homovanillic Acid Levels in Depressed Patients with a History of Alcoholism

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