High COPD prevalence at high altitude: does household air pollution play a role?

Brakema, Evelyn A; Tabyshova, Aizhamal; Kasteleyn, Marise J.; Molendijk, Eveline; Kleij, Rianne van der; Boven, Job F M van; Emilov, Berik; Akmatalieva, Meerim; Mademilov, Maamed; Numans, Mattijs E.; Williams, Siân; Sooronbaev, Talant; Chavannes, Niels H.

doi:10.1183/13993003.01193-2018

Cited by 47 publications

(57 citation statements)

References 41 publications

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“…4 A study by Brakema et al, in Kyrgyzstan, during 2015-2014 found that the prevalence of COPD was directly associated with moderate to high PM 2.5 concentrations. 29 Also, Phosri et al, found that there was a significant relation between exposure to NO 2 , CO, PM 10 and increased hospital admissions because of pneumonia, COPD, and asthma in Bankok, Thailand; while O 3 and SO 2 were associated with hospital admission for COPD and asthma as well. 30 A study by Gao et al performed in Beijing, China, showed that short-term exposure to PM 2.5 , PM 10 , NO 2 , SO 2 , and CO caused hospitalization due to COPD.…”

Section: Introductionmentioning

confidence: 99%

<p>Acute Effects of Air Pollution on Hospital Admissions for Asthma, COPD, and Bronchiectasis in Ahvaz, Iran</p>

Raji¹,

Riahi²,

Borsi³

et al. 2020

COPD

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Background and Aim: Although air pollution is a serious problem in Ahvaz, the association between air pollution and respiratory diseases has not been studied enough in this area. The aim of this study was to determine the relation between short-term exposure to air pollutants and the risk of hospital admissions due to asthma, COPD, and bronchiectasis in Ahvaz. Methods: Hospital admissions data and air pollutants including O 3 , NO, NO 2 , SO 2 , CO, PM 10, and PM 2.5 were obtained from 2008 to 2018. Adjusted Quasi-Poisson regression with a distributed lag model, controlled for trend, seasonality, weather, weekdays, and holidays was used for data analysis. Results: The results showed a significant increase in hospital admissions for asthma (RR=1.004, 95% CI: 1.002-1.007) and COPD (RR=1.003, 95% CI: 1.001-1.005) associated with PM 2.5 . PM 10 was associated with increased hospital admissions due to bronchiectasis in both genders (Men: RR=1.003, 95% CI: 1.001-1.006) (Female: RR=1.003, 95% CI: 1.000-1.006). NO 2 was also associated with an increased risk of hospital admissions for asthma (RR=1.040, 95% CI: 1.008-1.074) and COPD (RR=1.049, 95% CI: 1.010-1.090). SO 2 was associated with the risk of hospital admissions of asthma (RR=1.069, 95% CI: 1.017-1.124) and bronchiectasis (RR=1.030, 95% CI: 1.005-1.056). Finally, CO was associated with COPD (RR=1.643, 95% CI: 1.233-2.191) and bronchiectasis (RR=1.542, 95% CI: 1.035-2.298) hospital admissions. Conclusion: Short-term exposure to air pollutants significantly increases the risk of hospital admissions for asthma, COPD, and bronchiectasis in the adult and elderly population.

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Section: Introductionmentioning

confidence: 99%

<p>Acute Effects of Air Pollution on Hospital Admissions for Asthma, COPD, and Bronchiectasis in Ahvaz, Iran</p>

Raji¹,

Riahi²,

Borsi³

et al. 2020

COPD

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“…The level of air pollution is often measured by the concentration of particles of less than 2.5 µm in the air (PM2.5). The average PM2.5 levels measured by BRAKEMA et al [9] in the highlands of Kyrgyzstan were 290 μg·m −3 , and the maximum levels reached 5822 μg·m −3 . This contrasts with the World Health Organization recommended 24-h level of 25 μg·m −3 .…”

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confidence: 76%

“…The study reported by BRAKEMA et al [9] is a welcome addition to the still limited literature on household air pollution and health in low and middle income settings [16]. Studies on the effects of long term exposure to air pollution are especially needed, as the current estimates of global burden of disease at high pollution levels are based on cohort studies in high income countries (with low levels) and extrapolations based on exposure to passive and active smoking [18].…”

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confidence: 99%

“…These include exposure to colder temperatures and lower humidity, absence of house dust mite allergens above 1600 m [5], malnutrition [6], low birth weight [7], genetic variations [8] or living in a more rural environment, which may lead to differences in occupation and occupational exposures or physical activity levels, among other factors (figure 1). In this issue of the European Respiratory Journal (ERJ), BRAKEMA et al [9] analyse the effect of another variable, household air pollution, which they hypothesise can explain the differences in COPD prevalence by altitude.…”

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confidence: 99%

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Household air pollution as an important factor in the complex relationship between altitude and COPD

Basagaña

2019

Eur Respir J

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“…3 Around 400 million people live in high altitude (>1500 meters above sea-level) and this geographical altitude is associated with COPD prevalence, and adaptation mechanism of these patients. 4 In COPD patients living in high altitude areas, altitude could induce a higher growth of airways relative to lung size, causing to an increased FEV1/FVC ratio and it may cause chronic hypoxia. 5 In high altitude, to compensate for the low pressure of oxygen, many physiological changes occur in the human blood circulation.…”

Section: Introductionmentioning

confidence: 99%

Comparison of complete blood counts of stable COPD patients at two different altitude in Turkey.

Perinçek¹,

Avcı²,

Yılmam³

2019

TPMJ

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Introduction: The aim of this study was to evaluate how altitude difference affects complete blood count (CBC) in patients with stable Chronic Obstructive Pulmonary Disease (COPD). Study Design: Cross-sectional study. Setting: Department of Pulmonology, Kars Harakani State Hospital (Group 1) and Samsun Chest Diseases and Thoracic Surgery Hospital (Group 2), Turkey. Period: Six months i.e. from March to September 2018. Material and Methods: A total of 400 patients (200 female, 200 male) with stable COPD were included. For each group, 100 female and 100 male patients were randomly selected from hospitals. Age, BMI (kg/m2), comorbidity, smoking status, CBC were evaluated. Hemoglobin, hematocrit, WBC, MPV, platelet, lymphocyte count and percentage, platelet/lymphocyte rate (PLR), neutrophil count and percentage, neutrophil /lymphocyte rate (NLR), eosinophil count and percentage, PDW, PCT were recorded. Results: Patients living at high altitude were significantly older, had lower weight and had lower FEV1 levels. COPD stages of Group 1 patients were more severe (p<0.001). There were no moderate COPD patients in this group and the patients had fewer comorbidities (43%). Hemoglobin, hematocrit, MPV, WBC, neutrophil count and percentage, NLR and PLR were significantly higher in Group 1 (p<0.001). PDW, PCT, lymphocyte count and percentage, eosinophil count and percentage were significantly higher in Group 2 patients (p<0.001). Conclusion: Hemoglobin, hematocrit, MPV, WBC, neutrophil count and percentage, NLR and PLR were higher in patients living at high altitude. PDW, PCT, lymphocyte count and percentage, eosinophil count and percentage were significantly higher in patients living at low altitude.

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High COPD prevalence at high altitude: does household air pollution play a role?

Cited by 47 publications

References 41 publications

<p>Acute Effects of Air Pollution on Hospital Admissions for Asthma, COPD, and Bronchiectasis in Ahvaz, Iran</p>

<p>Acute Effects of Air Pollution on Hospital Admissions for Asthma, COPD, and Bronchiectasis in Ahvaz, Iran</p>

Household air pollution as an important factor in the complex relationship between altitude and COPD

Comparison of complete blood counts of stable COPD patients at two different altitude in Turkey.

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