High consumption of Nickel‐containing foods and IBS-like disorders: late events in a gluten-free diet

Picarelli, Antonio; Greco, Nicoletta; Sciuttini, Flavia; Marini, Cristiano; Meacci, Arianna

doi:10.1016/j.ecoenv.2021.112492

Cited by 9 publications

(4 citation statements)

References 7 publications

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“…In addition to the physical symptoms, the present study also evaluated the psychological intervention effect of LF-GFD on IBS patients using the Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS). [20] The results showed that the LF-GFD group signi cantly alleviated negative emotions, such as anxiety and depression, in IBS patients compared to the control group. This suggests that LF-GFD intervention may have a positive impact on the psychological well-being of individuals with IBS [21] .…”

Section: Discussionmentioning

confidence: 92%

Efficacy and safety of a Low-FODMAP combined with gluten-free diet in adult irritable bowel syndrome: a systematic review and meta-analysis

Zhang,

Yu,

et al. 2024

Preprint

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Background: Irritable Bowel Syndrome (IBS) is a prevalent gastrointestinal disorder characterized by symptoms such as abdominal pain, bloating, and altered bowel habits. A Low-FODMAP diet combined with a gluten-free diet (LF-GFD) has been proposed as a potential treatment approach. Objective: This study aimed to investigate the application of a low-FODMAP combined with gluten-free diet (LF-GFD) in patients with irritable bowel syndrome (IBS). Methods: Clinical studies that evaluated the intervention of LF-GFD in the treatment of IBS patients were identified through strict inclusion and exclusion criteria from online databases. The outcomes assessed the efficacy of LF-GFD in IBS patients using the following measures: Visual Analog Scale (VAS) for bloating and pain, IBS Symptom Severity Scale (IBS-SSS), and IBS Quality of Life (IBS-QoL) scores. Additionally, the psychological intervention effect of LF-GFD on IBS patients was evaluated using the Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS). Results: 4 RCTs and 4 cohort studies were included which involving 437 patients (221 patients with LF-GFD diet and 216 with GFD). The pooled results showed LF-GFD Alleviated the VAS bloating scores (RR=-0.58, 95%CI: -0.92--0.23, P=0.0010, I2=83%) and VAS pain scores (RR=-0.42, 95%CI: -0.66--0.19, P=0.005, I2=58%). Besides that, LF-GFD showed significant improvement of IBS-SSS (MD=-1.42, 95%CI: -2.74--0.10, P=0.03, I2=24%) scores and IBS-QoL scores (MD=3.75, 95%CI: 0.98-6.53, P=0.008, I2=33%). Furthermore, SDS (MD=-2.56, 95%CI: -3.38--1.74, P<0.00001, I2=65%) and SAS(MD=-4.30, 95%CI: -6.53--2.24, P<0.0001, I2=0%) scores were significantly decreased in LF-GFD group compared to GFD group. Conclusion: LF-GFD intervention effectively improves clinical symptoms and alleviates anxiety and depression in patients with irritable bowel syndrome.

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Section: Discussionmentioning

confidence: 92%

Efficacy and safety of a Low-FODMAP combined with gluten-free diet in adult irritable bowel syndrome: a systematic review and meta-analysis

Zhang,

Yu,

et al. 2024

Preprint

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“…It demonstrates an evolution in potential risk to human health to Ni exposure due to the shift towards a more plant-based diet [ 15 , 16 , 17 , 18 , 19 , 20 ]. Ni-allergic contact mucositis (Ni-ACM) is a disorder where Ni-containing food can impact previously sensitized patients and can be diagnosed by a Ni oral mucosa PT (omPT) [ 21 ]. Celiac disease patients on a gluten-free diet with positive Ni-omPT displayed a recurrence of gastrointestinal and extraintestinal symptoms, although serological and histological remission has been reached.…”

Section: Exposurementioning

confidence: 99%

Metal Allergy: State-of-the-Art Mechanisms, Biomarkers, Hypersensitivity to Implants

Zemelka‐Wiącek¹

2022

JCM

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Metal allergy is mainly an environmental disorder which can cause allergic contact dermatitis. Environmental metal exposures include jewelry, everyday metal items, mobile phones, leather, metal-rich food and implants, including stents or anchors. While consumer exposure is liable for the majority of metal hypersensitivity cases, the significance of occupational exposure to metals remains relevant. Although the most common metal allergens are nickel, chromium, and cobalt; however, lately, gold, palladium, titanium, and some others have also attracted attention. This review highlights advances in metal allergy mechanisms, biomarkers for potential patients’ stratification as well as biological treatments. The most recent evidence of human exposure to metal for risk assessment is discussed, as well as the relationship between the occurrence of metal hypersensitivity and implanted devices, including non-characteristic symptoms. The latest data on the diagnosis of metal hypersensitivity are also reported.

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“…In this condition, the affected population presents with a wide variety of symptoms that are generally identified as an IBS-like syndrome, including bloating, diarrhea, and abdominal pain [ 4 ]. Additionally, various systemic manifestations, such as dermatological, joint, and respiratory disorders, may also occur in affected patients [ 5 ]. Furthermore, neurological and behavioural disorders, such as foggy mind, impaired motor coordination, and space–time disorientation can also frequently be observed [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

New Insights and Evidence on “Food Intolerances”: Non-Celiac Gluten Sensitivity and Nickel Allergic Contact Mucositis

et al. 2023

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The clinical examination of patients often includes the observation of the existence of a close relationship between the ingestion of certain foods and the appearance of various symptoms. Until now, the occurrence of these events has been loosely defined as food intolerance. Instead, these conditions should be more properly defined as adverse food reactions (AFRs), which can consist of the presentation of a wide variety of symptoms which are commonly identified as irritable bowel syndrome (IBS). In addition, systemic manifestations such as neurological, dermatological, joint, and respiratory disorders may also occur in affected patients. Although the etiology and pathogenesis of some of them are already known, others, such as non-celiac gluten sensitivity and adverse reactions to nickel-containing foods, are not yet fully defined. The study aimed to evaluate the relationship between the ingestion of some foods and the appearance of some symptoms and clinical improvements and detectable immunohistochemical alterations after a specific exclusion diet. One hundred and six consecutive patients suffering from meteorism, dyspepsia, and nausea following the ingestion of foods containing gluten or nickel were subjected to the GSRS questionnaire which was modified according to the “Salerno experts’ criteria”. All patients underwent detection of IgA antibodies to tissue transglutaminase, oral mucosal patch tests with gluten and nickel (OMPT), and EGDS, including biopsies. Our data show that GSRS and OMPT, the use of APERIO CS2 software, and the endothelial marker CD34 could be suggested as useful tools in the diagnostic procedure of these new pathologies. Larger, multi-center clinical trials could be helpful in defining these emerging clinical problems.

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High consumption of Nickel‐containing foods and IBS-like disorders: late events in a gluten-free diet

Cited by 9 publications

References 7 publications

Efficacy and safety of a Low-FODMAP combined with gluten-free diet in adult irritable bowel syndrome: a systematic review and meta-analysis

Efficacy and safety of a Low-FODMAP combined with gluten-free diet in adult irritable bowel syndrome: a systematic review and meta-analysis

Metal Allergy: State-of-the-Art Mechanisms, Biomarkers, Hypersensitivity to Implants

New Insights and Evidence on “Food Intolerances”: Non-Celiac Gluten Sensitivity and Nickel Allergic Contact Mucositis

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