High Concentrations of Haemoglobin A2 in Malaria Patients

Arends, Tulio

doi:10.1038/2151517a0

Cited by 18 publications

(5 citation statements)

References 12 publications

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“…In our study there were several instances where members of the same families had elevated HbA2 concen trations and also 2 children with the haemo globin pattern of homozygous /Mhalassae mia. Although malaria [Arends, 1967], bilharzia [van Ros et al, 1967] and hepatitis A [Chastel et al, 1971], common infections in Liberia, have all been implicated in ef fecting a rise in the concentration of HbA2 into the range normally associated with /Mhalassaemia, we do not consider these infections to have played any significant role in influencing the results of our study. Work in northern Liberia [Willcox et al, 1979] on a similar population group showed that any influence by malaria in increasing HbA2 levels was negligible and did not in validate using this parameter for recognising /Mhalassaemia trait.…”

Section: Discussioncontrasting

confidence: 39%

Haemoglobin Variants, β-Thalassaemia and G-6-PD Types in Liberia

Willcox

Beckman

1981

Hum Hered

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Haemoglobin variants, β-thalassaemia and glucose-6-phosphate dehydrogenase (G-6-PD) types were studied in 702 individuals from Buchanan, Liberia. In this population haemoglobins S and C, β-thalassaemia and G-6-PD deficiency were found together. There was a considerable tribal variation. In the tribes of eastern Liberia the S- and C-genes were uncommon and the β-thalassaemia gene was rather frequent, while in western Liberia the S- and C-genes were more frequent and β-thalassaemia uncommon. In the central and northern parts the S- and β-thalassaemia genes were found together in relatively high frequencies, The rate of malaria infection was found to be lower in individuals with the sickle cell and β-thalassaemia traits than in individuals with haemoglobin AA, but the difference was not statistically significant. The frequency of the δ-chain gene B₂ was 1.4% in the total material and there was no significant tribal variation for this gene. The frequency of G-6-PD deficiency estimated in males was 16%.

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Section: Discussioncontrasting

confidence: 39%

Haemoglobin Variants, β-Thalassaemia and G-6-PD Types in Liberia

Willcox

Beckman

1981

Hum Hered

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“…P. vivax malaria increases Hb A2 levels and the effect persists for a long time after an attack of malaria (Arends, 1967). Our study in P. fa2cQmwn malaria revealed no increase in Hb A, lcvels (Wasi et al, 1971).…”

Section: Authorsmentioning

confidence: 41%

Haematological Data in 312 Cases of β‐Thalassaemia Trait in Thailand

1973

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The haematological data are presented in 312 individuals of Thai or Chinese extraction with the high A2 p-thalassaemia trait. The mean haemoglobin concentrations were 12.1 g x among males and 10.8 g"/;: among fcmalcs; 54% of thc subjccts wcre not anacmic and all wcrc asyniptomatic. Low MCV, MCH and MCHC values were found in 67%, 81 % aiid 6 "/, rcspcctively; erythrocytosis was detected in 34 %. Variable hypochromia and microcytosis were usually present, but

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“…Since the main criteria for the detection of /Bthalassaemia was an elevated Hb A2 level, and as malaria is endemic in Liberia-especially in the Nimba area it was essential to consider the effect that this infection could have on the results in view of reports (Arends, 1967;Eng, Lopez, and Lopes, 1971) that malaria may cause a rise in Hb A2 even into the thalassaemia range. Part of the survey was devoted to this problem.…”

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confidence: 99%

Thalassaemia in northern Liberia. A survey in the Mount Nimba area.

Willcox¹

1975

Journal of Medical Genetics

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Summary. A population survey in northern Liberia showed an average incidence of 900 of ,B-thalassaemia trait. There was considerable tribal variation, the highest rates being mainly found in tribes having a low incidence ofHb S. A single example of 8fl-thalassaemia trait was also found; the incidence of 8-chain variants was 1.8%. The effect of malaria on Hb A2 levels was investigated but appeared to be negligible. The problems of P-thalassaemia and Hb S occurring in the same population are discussed. It is considered that, although made on a local sample, the results of this survey indicate a high incidence of f-thalassaemia trait elsewhere in Liberia and that this is a suitable area for investigations of linkage at ,3-and 8-chain loci. No conclusion is at present possible from the data on the presence of a-thalassaemia although 10% of neonates were found to have increased levels of Hb Barts.

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High Concentrations of Haemoglobin A2 in Malaria Patients

Cited by 18 publications

References 12 publications

Haemoglobin Variants, β-Thalassaemia and G-6-PD Types in Liberia

Haemoglobin Variants, β-Thalassaemia and G-6-PD Types in Liberia

Haematological Data in 312 Cases of β‐Thalassaemia Trait in Thailand

Thalassaemia in northern Liberia. A survey in the Mount Nimba area.

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High Concentrations of Haemoglobin A2 in Malaria Patients

Cited by 18 publications

References 12 publications

Haemoglobin Variants, &beta;-Thalassaemia and G-6-PD Types in Liberia

Haemoglobin Variants, &beta;-Thalassaemia and G-6-PD Types in Liberia

Haematological Data in 312 Cases of β‐Thalassaemia Trait in Thailand

Thalassaemia in northern Liberia. A survey in the Mount Nimba area.

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Product

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Haemoglobin Variants, β-Thalassaemia and G-6-PD Types in Liberia

Haemoglobin Variants, β-Thalassaemia and G-6-PD Types in Liberia