High concentrations of atrial natriuretic peptide and brain natriuretic peptide in rat pericardial fluid and their reduction by reserpine in vivo

Klemola, Rauli; Laine, Mika; Weckström, Matti; Vuolteenaho, Olli; Ruskoaho, Heikki; Huttunen, Pirkko; Leppäluoto, Juhani

doi:10.1007/bf00168565

Cited by 13 publications

(7 citation statements)

References 30 publications

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“…This is observed, for instance, for endothelin-1 (Horkay et al, 1995), FGF-2 (Corda et al, 1997), and atrial natriuretic peptide (Amano et al, 1993;Corda et al, 1997) in heart surgery patients. Also, in rats, concentrations of atrial natriuretic peptide in pericardial fluid are higher than in plasma (Klemola et al, 1995). The present study shows that these high pericardial fluid/plasma concentration ratios not only are a matter of local syntheses of the agents in the heart or in the mesothelial cells of the pericardium (Eid et al, 1994;Mebazaa et al, 1998), but can also be attributed to the relatively slow clearances of these agents, once "trapped" into pericardial space.…”

Section: Discussionmentioning

confidence: 51%

Pharmacokinetic Advantage of Intrapericardially Applied Substances in the Rat

Hermans

Essen²,

Struijker‐Boudier³

et al. 2002

J Pharmacol Exp Ther

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Intrapericardial application of therapeutic agents may open perspectives for target-directed therapy of the diseased heart. This study was performed to investigate whether intrapericardial drug application is beneficial from a pharmacokinetic point of view. Male Wistar rats were provided with intrapericardial and intravascular catheters for substance administration and sampling. Intrapericardial bolus injections of fluorescent macromolecules [fluorescein isothiocyanate (FITC)-rat IgG, molecular weight about 155 kDa; Texas Red rat serum albumin, mol. wt. 67 kDa; Texas Red fibroblast growth factor (FGF), mol. wt. 18 kDa; and FITC heparin, mean mol. wt. 18 kDa] resulted in substance concentrations in pericardial fluid that exceeded those in plasma, for several hours. Pericardial fluid volumes of catheter-instrumented rats, derived from (initial) central compartment volumes, ranged between 0.5 and 0.9 ml/kg. After chronic (7 days) intrapericardial infusions with osmotic minipumps, pericardial fluid/plasma concentration ratios (local advantages) were 7 to 10 for the fluorescent proteins and Ͼ30 for FITC-heparin. This can be explained by the low substance clearances in pericardial fluid compared with plasma. Local advantages of the small substances cortisol (mol. wt. ϭ 362.5) and a carbonic acid derivative thereof (mol. wt. ϭ 348) were 14 and 420. Intrapericardial infusion of 125

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Section: Discussionmentioning

confidence: 51%

Pharmacokinetic Advantage of Intrapericardially Applied Substances in the Rat

Hermans

Essen²,

Struijker‐Boudier³

et al. 2002

J Pharmacol Exp Ther

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“…The existence of a high number of vesicles of micropinocytosis suggests an active exchange of solutes with the pericardial cavity. This may be important since the pericardial fluid contains atrial natriuretic peptides (ANP) in mammals (Klemola et al, 1995), and ANP‐binding sites have recently been described in the bulbus arteriosus of C. hamatus (Cerra et al, 1997). Pinocytotic activity of the visceral pericardium may control the passage of these and other substances, thus modulating a number of heart activities.…”

Section: Discussionmentioning

confidence: 99%

Bulbus arteriosus of the antarctic teleosts. I. The white-bloodedChionodraco hamatus

et al. 1999

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The bulbus arteriosus of teleost fish is a thick-walled chamber that extends between the single ventricle and the ventral aorta. The functional importance of the bulbus resides in the fact that it maintains a steady blood flow into the gill system through heart contraction. Despite of this, a thorough study of the structure of the bulbus in teleost fish is still lacking. We have undertaken a morphologic study of the bulbus arteriosus in the stenothermal teleosts of the Antarctic sea. The structural organization of the bulbus arteriosus of the icefish Chionodraco hamatus has been studied here by conventional light, scanning, and transmission electron microscopy.The inner surface of the bulbus shows a festooned appearance due to the presence of longitudinal, unbranched ridges that extend between the ventricle and the arterial trunk. The wall of the bulbus is divided into endocardial, subendocardial, middle, and external layers. Endocardial cells show a large number of moderately-dense bodies. The endocardium invaginates into the subendocardium forming solid epithelial cords that contain numerous secretory vacuoles. Cells in the subendocardium group into small domains, have some of the morphological characteristics of smooth muscle cells, and appear enmeshed in a three-dimensional network of matrix filaments. Cells in the middle layer are typical smooth muscle cells. They appear arranged into layers and are surrounded by a filamentous meshwork that excludes collagen fibers. Orientation of this meshwork occurs in the vicinity of the smooth muscle cells. Elastin fibers are never observed. The external layer is formed by wavy collagen bundles and fibroblast-like cells. This layer lacks blood vessels and nerve fibers.The endocardium and the endocardium-derived cords are secretory epithelia that may be involved in the formation of mucins or glycosaminoglycans. These mucins may have a protecting effect on the endocardium. The subendocardium and the middle layer appear to be formed by the same cell type, smooth muscle, with a gradient of differentiation from the secretory (subendocardium) to the contractile (middle layer) phenotype. Despite the absence of elastin fibers, the filamentous matrix could maintain the elastic properties of the bulbus wall. Smooth muscle cells appear to be actively involved in bulbus wall dynamics. The restriction of collagen to the external layer suggests that it may control wall dilatation and bulbus compliance.

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“…interchange of solutes with the pericardial cavity. The pericardial fluid contains active peptides (Klemola et al, 1995). Passage of these peptides may be useful to control a number of heart activities , including smooth muscle cells.…”

Section: Discussionmentioning

confidence: 99%

The bulbus arteriosus of stenothermal and temperate teleosts: a morphological approach

ICARDO¹

2000

Journal of Fish Biology

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High concentrations of atrial natriuretic peptide and brain natriuretic peptide in rat pericardial fluid and their reduction by reserpine in vivo

Cited by 13 publications

References 30 publications

Pharmacokinetic Advantage of Intrapericardially Applied Substances in the Rat

Pharmacokinetic Advantage of Intrapericardially Applied Substances in the Rat

Bulbus arteriosus of the antarctic teleosts. I. The white-bloodedChionodraco hamatus

The bulbus arteriosus of stenothermal and temperate teleosts: a morphological approach

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