High-concentration zeta potential measurements using light-scattering techniques

Kaszuba, Michael; Corbett, Jason C.W.; Watson, F.M.; Jones, Andrew

doi:10.1098/rsta.2010.0175

Cited by 288 publications

(214 citation statements)

References 12 publications

(17 reference statements)

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“…When a particle changes its place (e.g., by gravity or other forces), the ions in the boundary also move with it, but none of the ions beyond the boundary move. This boundary is named the slipping plane or surface of hydrodynamic shear [36] The potential related to this boundary is known as the Zeta potential ( Figure 1B) and its value is a measure of system stability. Particles with large negative or positive zeta potentials are usually considered stable.…”

Section: Theoretical Charge and Molecular Size Determinationmentioning

confidence: 99%

Accurate determination of key surface properties that determine the efficient separation of bovine milk BSA and LF proteins

Valiño

Román

Ibáñez

et al. 2014

Separation and Purification Technology

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. KeywordsDynamic light scattering, Zeta Potential, Bovine Serum Proteins, Bioprocess Design. AbstractThe aim of this work is to accurately measure fundamental surface properties, i.e., zeta potential, isoelectric point and protein size that determine the optimal separation conditions of Bovine serum albumin and lactoferrin, two high added value food proteins whose similarity in weight makes their separation a scientific and technical challenge.

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Section: Theoretical Charge and Molecular Size Determinationmentioning

confidence: 99%

Accurate determination of key surface properties that determine the efficient separation of bovine milk BSA and LF proteins

Valiño

Román

Ibáñez

et al. 2014

Separation and Purification Technology

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“…For an aqueous solution of moderate electrolyte concentration, a value of 1.5 is used, which is also known as the Smolichowski approximation [78]. To calculate the zeta potential in a non-polar liquid, Huckel's approximation is used and f(ka) becomes equal to 1 [79].…”

Section: Zeta Potentialmentioning

confidence: 99%

Charge of water droplets in non-polar oils

Schoeler

Josephides

Sajjadi

et al. 2013

Journal of Applied Physics

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Recent advances in droplet manipulation methods by electric fields and signals require a deeper understanding of water droplet charge. In this paper, we have investigated the electrophoretic motion of individual water microdroplets injected into non-polar silicone and paraffin oil by video optical microscopy on an individual droplet basis to determine droplet charge. It was found that the initial surface charge density of surfactant free droplets directly after injection from a micropipette is positive and of the order of 10−6 C/m2, regardless of pH and ion concentration in the range from pH 4 to pH 10 and from 0.01 mmol/l to 1.5 mol/l, respectively. The experimental results together with molecular dynamics simulations show that the nature and polarity of the charge can be explained by anisotropic orientation of water molecules at the interface rather than selective adsorption of ions. Furthermore, we showed that slip at the liquid-liquid boundary must be taken into account when interpreting electrophoretic measurements of droplets.

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“…Similarly, the zeta potential was measured using the same equipment with a combination of laser doppler electrophoresis (Clogston and Patri, 2011;Kaszuba et al, 2010). Each experiment was performed in triplicate.…”

Section: Particle Size and Zeta Potentialmentioning

confidence: 99%

Efficacy of edelfosine lipid nanoparticles in breast cancer cells

Aznar

Lasa-Saracíbar

Mendoza

et al. 2013

International Journal of Pharmaceutics

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Breast cancer is a heterogeneous group of neoplasms predominantly originating in the terminal duct lobular units. It represents the leading cause of cancer death in women and the survival frequencies for patients at advanced stages of the disease remain low.New treatment options need to be researched to improve these rates. The anti-tumor ether lipid edelfosine (ET) is the prototype of a novel generation of promising anticancer drugs. However it presents several drawbacks for its use in cancer therapy, including gastrointestinal and hemolytic toxicity and low oral bioavailability. To overcome these obstacles, ET was encapsulated in Precirol ATO 5 lipid nanoparticles (ET-LN), and its anti-tumor potential was in vitro tested in breast cancer. The formulated ET-LN were more effective in inhibiting cell proliferation and notably decreased cell viability, showing that the cytotoxic effect of ET was considerably enhanced when ET was encapsulated.In addition, ET and ET-LN were able to promote cell cycle arrest at G1 phase.

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High-concentration zeta potential measurements using light-scattering techniques

Cited by 288 publications

References 12 publications

Accurate determination of key surface properties that determine the efficient separation of bovine milk BSA and LF proteins

Accurate determination of key surface properties that determine the efficient separation of bovine milk BSA and LF proteins

Charge of water droplets in non-polar oils

Efficacy of edelfosine lipid nanoparticles in breast cancer cells

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