High concentration honey chitosan electrospun nanofibers: Biocompatibility and antibacterial effects

Sarhan, Wessam A.; Azzazy, Hassan M.E.

doi:10.1016/j.carbpol.2014.12.051

Cited by 121 publications

(67 citation statements)

References 39 publications

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“…For instance, acetic acid used at concentration from 90% down to 1% (or 0.17 M) gives good fibers [16,25]. It is important to mention that pure chitosan fibers have rarely been obtained in acetic acid at 90% and 70% [19], but mainly with trifluoroacetic acid (TFA) [14,26] or mixture of TFA and dichloromethane [23,27].…”

Section: Introductionmentioning

confidence: 99%

“…The use of ionic liquid was also mentioned with 1,1,1,3,3,3-hexafluoro-2-propanol [28]. More generally, it has been shown that fine nanofibers can be obtained in chitosan blends with poly (vinyl alcohol) (PVA) [23,25,29,30], gelatin or collagen [2,7,31,32,33,34], silk fibroin [5], polycaprolactone [35] but mainly with poly(ethylene oxide) (PEO) [6,17,18,36,37,38,39,40,41]. Usually, to generate composite fibers the spinning solutions are obtained by mixing the two polymers solutions prepared separately in the same solvent.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of Pure and Stable Chitosan Nanofibers by Electrospinning in the Presence of Poly(ethylene oxide)

Lemma

Bossard

Rinaudo³

2016

IJMS

101

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Electrospinning was employed to obtain chitosan nanofibers from blends of chitosans (CS) and poly(ethylene oxide) (PEO). Blends of chitosan (MW (weight-average molecular weight) = 102 kg/mol) and PEO (M (molecular weight) = 1000 kg/mol) were selected to optimize the electrospinning process parameters. The PEO powder was solubilized into chitosan solution at different weight ratios in 0.5 M acetic acid. The physicochemical changes of the nanofibers were determined by scanning electron microscopy (SEM), swelling capacity, and nuclear magnetic resonance (NMR) spectroscopy. For stabilization, the produced nanofibers were neutralized with K2CO3 in water or 70% ethanol/30% water as solvent. Subsequently, repeated washings with pure water were performed to extract PEO, potassium acetate and carbonate salts formed in the course of chitosan nanofiber purification. The increase of PEO content in the blend from 20 to 40 w% exhibited bead-free fibers with average diameters 85 ± 19 and 147 ± 28 nm, respectively. Their NMR analysis proved that PEO and the salts were nearly completely removed from the nanostructure of chitosan, demonstrating that the adopted strategy is successful for producing pure chitosan nanofibers. In addition, the nanofibers obtained after neutralization in ethanol-aqueous solution has better structural stability, at least for six months in aqueous solutions (phosphate buffer (PBS) or water).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation of Pure and Stable Chitosan Nanofibers by Electrospinning in the Presence of Poly(ethylene oxide)

Lemma

Bossard

Rinaudo³

2016

IJMS

101

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“…The results showed that 75% CS in the membrane inhibited bacterium from growth and led to better filtration than CS ratios of 25% and 50%. A high concentration of honey was added into CS and PVA blended solutions by Wessam A [26]. They found that honey reduced the viscosity and achieved the spinning requirement.…”

Section: Introductionmentioning

confidence: 99%

Needleless Electrospun PVA/Chitosan Nano Fiber Membrane and its Antibacterial Property

Pan¹

2017

JTEFT

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Poly vinyl alcohol (PVA), which is a low-volatility, environmentally friendly and water-soluble polymer, is suitable for needleless electro spinning. Chitosan (CS) has drawn much attention due to its excellent antibacterial properties; however, it is hard to needle lessly electro spin CS alone. Thus, a certain amount of CS was added into the electro spinning solution to fabricate PVA nano fibers with antibacterial properties. In this paper, a needleless electro spinning device with spiral disk spinnerets was used to prepare PVA with different concentrations of CS nano fiber membranes. The effects of electro spinning parameters on process stability and anti-water-soluble processing were investigated. The results showed that the electro spinning process was associated with voltage, rotation speed and collection distance. The optimal electro spinning parameters are a voltage of 75 kV, a rotation speed of 11 rpm and a distance of 190 mm. From the comparison and analysis, 5% glutaraldehyde (GA) solution treatment is the superior method to increase the anti-water-solubility of the membrane. The antibacterial properties of PVA/CS nano fiber membranes with CS concentrations ranging from 1.0% to 1.5% were also investigated. The results showed that the inhibition rates of Escherichia coli (E. coli) were all above 99%, and those of Staphylococcus aureus (S. aureus) were all above 90%. Moreover, GA solution treatment has no effect on the antibacterial performance.

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“…Recently, composite chitosan fibres with enhanced antibacterial properties have been prepared using natural bioactive compounds, such as essential oils and honey. [97][98][99][100] Cinnamon oil has been incorporated into chitosan/poly(ethylene oxide) (PEO) fibres having a diameter of around 50 nm. 97 The electrospun mats were able to release the essential oil in vitro, and exhibited antibacterial activity against E. coli and P. aeruginosa.…”

Section: Chitosanmentioning

confidence: 99%

Electrospinning of natural polymers for advanced wound care: towards responsive and adaptive dressings

2016

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High concentration honey chitosan electrospun nanofibers: Biocompatibility and antibacterial effects

Cited by 121 publications

References 39 publications

Preparation of Pure and Stable Chitosan Nanofibers by Electrospinning in the Presence of Poly(ethylene oxide)

Preparation of Pure and Stable Chitosan Nanofibers by Electrospinning in the Presence of Poly(ethylene oxide)

Needleless Electrospun PVA/Chitosan Nano Fiber Membrane and its Antibacterial Property

Electrospinning of natural polymers for advanced wound care: towards responsive and adaptive dressings

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