High Caveolin-1 mRNA expression in triple-negative breast cancer is associated with an aggressive tumor microenvironment, chemoresistance, and poor clinical outcome
Christopher Godina,
Somayeh Khazaei,
Mattias Belting
et al.
Abstract:Background
Currently, there are few treatment-predictive and prognostic biomarkers in triple-negative breast cancer (TNBC). Caveolin-1 (CAV1) is linked to chemoresistance and several important processes involved in tumor progression and metastasis, such as epithelial-mesenchymal transition (EMT). Herein, we report that high CAV1 gene expression is an independent factor of poor prognosis in TNBC.
Methods
CAV1 gene expression was compared across different molecular features (e.g., PAM50 subtypes). CAV1 express… Show more
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