High Catalase and Low Thiol Levels in Adult-ADHD Patients

Alpak, Gökay; Selek, Salih; Bulut, Mahmut; Bülbül, Feridun; Ünal, Ahmet; Virit, Osman; Kılıç, Osman Hasan Tahsin; Gergerlioğlu, H. Serdar; Savaş, Haluk A.

doi:10.5455/bcp.20140429091127

Cited by 5 publications

(6 citation statements)

References 18 publications

(22 reference statements)

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“…In the studies recruited adult ADHD patients, oxidative stress was reported to be increased 16,17 . In a recent meta-analysis, although significant correlations were identified between severities of ADHD symptoms and oxidative stress; similar antioxidant levels were found in treatmentnaïve ADHD patients and the control group 18 . No significant differences were found in 8-OHdG levels between the newly diagnosed ADHD patients and the control group 19 .…”

Section: Dopamine and Noradrenalinementioning

confidence: 78%

“…Lipids are more vulnerable to oxidation, and, thus, dopamine regulation may be affected 29 . Both genetic and environmental risk factors may increase oxidative Simsek S, Gencoglan S, Ozaner S, Kaplan I, Kaya MC stress levels, and in many studies, increased peripheral oxidative stress levels were found in patients with ADHD 18 . Some authors suggests that excessive intracellular iron accumulation in neurons may cause oxidative stress 30,31 .…”

Section: Discussionmentioning

confidence: 99%

“…In a study, vitamin E and total antioxidant levels were reported to be lower in the children with ADHD, compared to the control group 35,36 . However, there were substantial heterogeneities in characteristics of the participants, particularly in their ages, in both studies investigating oxidative stress and antioxidants 18 . Some of previous studies have reported increased oxidative stress in children with ADHD 17,[37][38][39][40] , whereas others, consistent with our study results, do not agree with that result 19 .…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant Status and DNA Damage in Children with Attention Deficit Hyperactivity Disorder with or without Comorbid Disruptive Behavioral Disorders

Şimşek

Gençoğlan

Kaplan

et al. 2016

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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Antioxidant status and DNA damage in children with attention deficit hyperactivity disorder with or without comorbid disruptive behavioral disorders Objective: The aim of this study is to investigate oxidative stress and DNA damage among children with attention deficit hyperactivity disorder (ADHD) with or without disruptive behavioral disorders (DBD). Methods: A total of 49 treatment naïve children (M/F: 40/9) who were diagnosed with ADHD according to the Diagnostic and Statistical Manual of Mental Disorders (DSM) IV criteria were included. The patients with ADHD were divided into two groups, those with ADHD alone (n= 25) and ADHD plus DBD (n=24). The control group consisted of 40 age-and sex-similar healthy children. The Schedule for Affective Disorders and Schizophrenia for School Aged Children-Present and Lifetime version (K-SADS-PL) was applied to all children. Children's teachers completed the Turgay DSM-IV Based Child and Adolescent Behavior Disorders Screening and Rating Scale (T-DSM-IV-S). Serum glutathione peroxidase (GPx), coenzyme Q, 8-hydroxy-2deoxyguanosine (8-OHdG) and superoxide dismutase (SOD) levels were measured by the ELISA method using commercial kits. Results: There were no significant differences in serum GPx, SOD, CoQ and 8-OHdG levels among the pure ADHD, ADHD plus DBD and the control groups (p>0.05). No statistically significant correlations were found between the severity of ADHD symptoms and GPx, SOD, CoQ and 8-OHdG levels. Conclusion: Our study suggests that oxidative stress may not play a key role in the pathogenesis of pure ADHD and ADHD plus DBD.

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Section: Dopamine and Noradrenalinementioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antioxidant Status and DNA Damage in Children with Attention Deficit Hyperactivity Disorder with or without Comorbid Disruptive Behavioral Disorders

Şimşek

Gençoğlan

Kaplan

et al. 2016

Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychophar

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“…CAT is a crucial enzyme for antioxidant mechanisms and decomposes hydrogen peroxide into water and oxygen. 33) Among anxiety disorders, CAT is reported to be increased in OCD and SP, but unchanged in PTSD. 20 , 22 , 27) However we found that CAT is decreased in GAD.…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Value of Malondialdehyde, Superoxide Dismutase and Catalase Activity in Drug Naïve, First Episode, Non-Smoker Generalized Anxiety Disorder Patients

Fındıklı

Camkurt²,

İzci

et al. 2018

Clin Psychopharmacol Neurosci

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ObjectiveGeneralized anxiety disorder (GAD) is a common anxiety disorder. Although lots of research done to reveal neurobiological basis of GAD, it is still unclear. Diagnosis of GAD depends on subjective complaints of patients, thus the need for a biological marker is constantly emerging. In this study, we aimed to investigate diagnostic value of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) in GAD.MethodsWe evaluated MDA, SOD, and CAT levels in peripheral blood of 46 patients and 45 controls. MDA was measured with Ohkawa’s methods, SOD was measured with Fridovich method, and CAT was measured with Beutler’s method.ResultsMDA was significantly increased in patients than controls, medians 4.05 nmol/mg and 1.71 nmol/mg respectively, p<0.001; SOD and CAT activity was significantly decreased in patients than controls, medians of SOD were 159.07 U/mg and 301.87 U/mg, p<0.001 respectively, medians for CAT were 138.47 U/mg and 160.60 U/mg respectively. We found high correlation between Hamilton Anxiety Rating Scale and SOD, MDA r values were 0.723 and 0.715 respectively, p<0.001 for both. Receiver operator characteristic (ROC) curve analysis showed high diagnostic performance for MDA and SOD, low diagnostic performance for CAT, areas under curve were 1.0, 1.0, and 0.648 respectively.ConclusionOur results reveal possible diagnostic value of MDA, less likely of SOD but not CAT. Future studies should investigate diagnostic value of oxidants and antioxidantn enzymes in larger samples and include diagnostic value of these parameters.

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“…They also noted that those with comorbid oppositional defiant disorder (ODD) had lower TAS than subjects with no comorbidity, and no difference was found in TOS or OSI among the ADHD subtypes. Alpak et al (16) found significantly lower thiol levels in adult ADHD patients than control group. They interpreted results to be a reaction to increased catalase (CAT) levels and that thiol acted like a pro-oxidant in their study.…”

Section: Introductionmentioning

confidence: 95%

Dikkat Eksikliği Hiperaktivite Bozukluğu Olan Çocuk ve Ergenlerde Tiyol/Disülfit Dengesi ve Oksidatif Stres Parametreler

Görmez¹,

Örengül²,

Özer³

et al. 2016

Anadolu Kliniği Tıp Bilimleri Dergisi

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Aim: Research investigating association between attention deficit/hyperactivity disorder (ADHD) and oxidative stress have reported conflicting and inconsistent findings. We aimed to investigate a novel oxidative stress marker, thiol/disulphide homeostasis, in patients with ADHD and compare the results with the healthy control group. Materials and Methods: A total of 47 medication naïve children and adolescents (35 boys and 12 girls) aged 6-17 years with a diagnosis of ADHD were investigated for oxidative stress parameters and results were compared with that of 41 subjects (28 boys and 13 girls) matched for age and gender. The Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (KSADS-PL) was conducted to support ADHD diagnosis and to exclude comorbid psychiatric disorders. Thiols, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) levels were measured in serum samples in addition to myeloperoxidase (MPO) and dynamic thiol/disulphide homeostasis. Results: TOS, OSI and MPO levels were significantly lower in ADHD group (p=0.001, p=0.022, p=0.007, respectively). Predominantly inattentive type ADHD had significantly higher levels of TAS (p=0.014) and TOS (p=0.01) than those with combined ADHD subtype. Oxidative stress index (OSI) levels decreased with increasing age in both ADHD and control groups as well in the whole sample when control and patient groups were tested together (r=-0.376, p=0.009; r=-0.479, p= 0.002; and r=-0.367, p<0.001, respectively). TAS scores significantly increased with age in ADHD group (r= 0.523, p<0.001). Thiol/disulphide homeostasis showed no difference. Discussion and Conclusion: The current study reveals no association between pediatric-age ADHD and thiol/disulphide homeostasis. The nature of relationship between oxidative stress and ADHD needs to be clarified with methodologically robust studies. Keywords: oxidative stress; thiol/disulphide homeostasis; attention deficit hyperactivity disorder; children and adolescents Özet Amaç: Bilimsel çalışmalar dikkat eksikliği hiperaktivite bozukluğu (DEHB) ve oksidatif stres arasındaki ilişki ile ilgili farklı ve tutarsız veriler sunmaktadır. Bu çalışmada DEHB hastalarında tiyol/ disülfit homeostazı gibi yeni bir oksidatif stres markırını incelemek ve sonuçları sağlıklı kontrol grubu ile karşılaştırmak amaçlanmıştır. Gereç ve Yöntemler: Çalışmaya psikotrop ilaç kullanım öyküsü olmayan 6-17 yaş aralığında ve DEHB tanılı 47 çocuk (35 erkek ve 12 kız) ve yaş ve cinsiyet olarak benzer 41 sağlıklı çocuk (28 erkek, 13 kız) dâhil edilmiştir. Total antioksidan seviyesi (TAS), total oksidan seviyesi (TOS), oksidatif stres indeksi (OSI), miyeloperoksidaz (MPO) ve dinamik tiyol/disülfit homeostazı gibi oksidatif stres parametreleri bu iki grup arasında karşılaştırılmıştır. Eş tanı durumu Okul Çağı Çocukları için Duygulanım Bozuklukları ve Şizofreni Görüşme Çizelgesi-Şimdi ve Yaşam Boyu Şekli-Türkçe Uyarlaması (ÇDŞG-ŞY-T) kullanılarak değerlendirilmiştir. Bulgula...

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High Catalase and Low Thiol Levels in Adult-ADHD Patients

Cited by 5 publications

References 18 publications

Antioxidant Status and DNA Damage in Children with Attention Deficit Hyperactivity Disorder with or without Comorbid Disruptive Behavioral Disorders

Antioxidant Status and DNA Damage in Children with Attention Deficit Hyperactivity Disorder with or without Comorbid Disruptive Behavioral Disorders

The Diagnostic Value of Malondialdehyde, Superoxide Dismutase and Catalase Activity in Drug Naïve, First Episode, Non-Smoker Generalized Anxiety Disorder Patients

Dikkat Eksikliği Hiperaktivite Bozukluğu Olan Çocuk ve Ergenlerde Tiyol/Disülfit Dengesi ve Oksidatif Stres Parametreler

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