High carbohydrate diet partially protects Nile tilapia (Oreochromis niloticus) from oxytetracycline-induced side effects

Limbu, Samwel Mchele; Zhang, Han; Luo, Yuan; Chen, Liqiao; Zhang, Meiling; Du, Zhen‐Yu

doi:10.1016/j.envpol.2019.113508

Cited by 38 publications

(53 citation statements)

References 67 publications

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“…2019; Limbu et al . 2020), excessive (Snieszko & Wood 1955) and different levels (Manning et al . 2013) of antibiotics, based on dose (Gaikowski et al .…”

Section: Growth Performance and Feed Utilizationmentioning

confidence: 99%

“…2019; Limbu et al . 2020), coupled with antibiotics mediated toxicity, which cause nutrients malabsorption (Zhang et al . 2015).…”

Section: Growth Performance and Feed Utilizationmentioning

confidence: 99%

“…2019; Limbu et al . 2020) and increased growth performance (Sanchez‐Martínez et al . 2008; He et al .…”

Section: Introductionmentioning

confidence: 99%

“…2018; Limbu et al . 2020) in various fish species. Moreover, antibiotics induced oxidative stress (Nunes et al .…”

Section: Introductionmentioning

confidence: 99%

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A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review

Limbu

Chen

Zhang

et al. 2020

Reviews in Aquaculture

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117

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The rearing of fish in intensive systems reduces their immunity leading to eruption of diseases, consequently prompting the use of antibiotics. Antibiotics are currently used in cultured fish globally to treat/prevent diseases. On the one hand, antibiotics used in aquaculture help to improve fish health by killing or inhibiting pathogenic bacteria proliferation. However, on the other hand, they cause multiple side effects. To date, information on systemic effects of antibiotics in cultured fish is scattered and their potential human health risk remains elusive. This review critically analyses and discusses the available information in the literature on the positive and negative effects of antibiotics in cultured fish and their potential human health risk via fish consumption. The review found 44 different antibiotics dominated by oxytetracycline were studied in various fish species worldwide. Antibiotics used in global aquaculture either decrease or increase fish growth and survival rates. They induce oxidative stress, which affect antioxidant and detoxification responses and cause host–microbiota dysbiosis. These changes compromise the fish immunity system, which ultimately lead to cellular damage. The toxicities generated inhibit the fish aerobic glycolysis, suppress lipogenesis and fatty acid β‐oxidation while increase energy demand by initiating gluconeogenesis and anaerobic glycolysis. Consumption of fish treated with antibiotics causes human health risk. Future studies are required on agents to restore dysfunctions induced by antibiotics in cultured fish, while attempts to limit their utilisation in aquaculture production are underway. [Correction added on 21 November 2020, after first online publication: The abstract has been amended to clarify the scope of the review.]

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“…2019; Limbu et al . 2020), excessive (Snieszko & Wood 1955) and different levels (Manning et al . 2013) of antibiotics, based on dose (Gaikowski et al .…”

Section: Growth Performance and Feed Utilizationmentioning

confidence: 99%

“…2019; Limbu et al . 2020), coupled with antibiotics mediated toxicity, which cause nutrients malabsorption (Zhang et al . 2015).…”

Section: Growth Performance and Feed Utilizationmentioning

confidence: 99%

See 2 more Smart Citations

A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review

Limbu

Chen

Zhang

et al. 2020

Reviews in Aquaculture

Self Cite

117

View full text Add to dashboard Cite

show abstract

“…According to Elia et al [ 92 ], Cyprinus carpio fed oxytetracycline at therapeutic level (75 mg/kg) or at high level (150 or 300 mg/kg) for 10 days exhibited impaired antioxidant system: hepatic SOD activity decreased, while activities of GPx and GR increased. Limbu et al [ 93 ] fed Oreochromis niloticus 80 mg/kg of oxytetracycline for 35 days and reported decreased hepatic SOD and GST activities, while serum MDA level and AST activity increased which indicates oxidative damage. In addition, intestinal and hepatic caspase 9 was upregulated which indicates increased apoptotic activity.…”

Section: Toxic Effects Of Antibacterials On Fish Organismsmentioning

confidence: 99%

Antibacterials in Aquatic Environment and Their Toxicity to Fish

2020

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Antibacterial agents are commonly present in aquatic environment at low concentrations. Terrestrial animal farms, human medicine and aquaculture are main sources of water contamination with antibacterials. Antibiotics were proved to be directly toxic to fish causing oxidative stress, general stress response, histopathological lesions, hematological, metabolic, and reproductive disorders, as well as immunosuppressive and genotoxic effects. Environmentally realistic low concentrations of antibiotics also disturb aquatic bacterial communities causing alterations in fish symbiotic microbiota and induce emergence of antibiotic-resistant pathogenic bacteria by exerting selective pressure on spread of antibiotic-resistance genes.

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Dietary low‐fat content supplemented with oxytetracycline impairs physiological functions in Nile tilapia (Oreochromis niloticus) fingerlings

Limbu

2024

Animal Research and One Health

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Nutrition modulates the vulnerability of animals to xenobiotics insults including antibiotics in cultured fish. However, studies exploring the role of low‐fat diet (LFD) in modulating adverse effects of antibiotics are currently limited. This study explored the physiological effects of feeding LFD supplemented with oxytetracycline (OTC) in Nile tilapia (Oreochromis niloticus) fingerlings. Thirty Nile tilapia (8.64 ± 0.44 g) were tagged and randomly stocked into three tanks and fed on a control diet (CD, 70 g/kg lipid), LFD (20 g/kg lipid) and the LFD supplemented with 2.00 g/kg diet of OTC (80 mg/kg body weight/day), hereafter LFD + OTC for 9 weeks. The results indicated that the Nile tilapia fed on LFD + OTC reduced growth performance and feed utilization efficiency than those fed on CD and LFD. Moreover, the fish fed on LFD + OTC had lower body composition, nutrients digestibility and mesenteric fat index than those fed on CD and LFD. Feeding the fish with LFD + OTC decreased antioxidant capacity in the liver than those fed on CD and LFD. The Nile tilapia fed on LFD + OTC increased hepatotoxicity than those fed on CD and LFD. Feeding the Nile tilapia on LFD + OTC decreased immunity response in the kidney and liver than those fed on CD and LFD. The LFD + OTC affected nutrients metabolism in the liver and serum than other diets. Taken together, feeding LFD with OTC impairs physiological functions of Nile tilapia by inhibiting growth performance, antioxidant capacity, immunity response and nutrient metabolism.

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High carbohydrate diet partially protects Nile tilapia (Oreochromis niloticus) from oxytetracycline-induced side effects

Cited by 38 publications

References 67 publications

A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review

A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review

Antibacterials in Aquatic Environment and Their Toxicity to Fish

Dietary low‐fat content supplemented with oxytetracycline impairs physiological functions in Nile tilapia (Oreochromis niloticus) fingerlings

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