High capacity tagging using nanostructured diffraction barcodes

Galitonov, G.; Birtwell, S.; Zheludev, Nikolay I.; Morgan, Hywel

doi:10.1364/oe.14.001382

Cited by 13 publications

(9 citation statements)

References 12 publications

(10 reference statements)

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“…Other, image-based labels include polymer particles graphically encoded by sequences of extruded dots [41,137] (Fig. 2c) or by the diffraction patterns of overlapping etched gratings [10,50].…”

Section: Signature-based Bioassaysmentioning

confidence: 99%

Magnetic biosensor technologies for medical applications: a review

Llandro

Palfreyman

Ionescu

et al. 2010

Med Biol Eng Comput

199

117

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In this review we discuss conventional methods of performing biological assays and molecular identification and highlight their advantages and limitations. An alternative approach based on magnetic nanotechnology is then presented. Firstly, magnetic carriers are introduced and their biocompatibility and functionalisation discussed, with spotlights on functionalisation via self assembled monolayers and on methods of reducing nonspecific binding. In addition an introduction is provided to the basic physical concepts behind the various types of sensors used to detect magnetic labels. Finally, progress in the field of magnetic biosensors and the outlook for the future are discussed.

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Section: Signature-based Bioassaysmentioning

confidence: 99%

Magnetic biosensor technologies for medical applications: a review

Llandro

Palfreyman

Ionescu

et al. 2010

Med Biol Eng Comput

199

117

View full text Add to dashboard Cite

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“…Optical encoding methods reported include spectrometric [1][2][3][4][5] (fluorophores, quantum dots and Raman tags), image-based or graphical [6,7] and diffractive [8] identification. Optical encoding methods reported include spectrometric [1][2][3][4][5] (fluorophores, quantum dots and Raman tags), image-based or graphical [6,7] and diffractive [8] identification.…”

Section: Introductionmentioning

confidence: 99%

Moment Selective Digital Detection of Single Magnetic Beads for Multiplexed Bioassays

Llandro

Hayward

Bland

et al. 2008

AIP Conference Proceedings

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Research into lab-on-a-chip multiplexed bioassays has focused on libraries of biochemical probes, indexed by optically encoded micron-sized labels. However, few current methods have reconciled large multiplexing capability with a rapid detection system amenable to miniaturization. Magnetic identification of labels provides a strong candidate solution to this problem, yet no proposed single-label magnetic detection system can both read and encode magnetic labels. We present a magnetic multiplexed assay in lab-on-a-chip format which identifies target biomolecules from the hybridization results by reading encoded magnetic beads. We show that a microfabricated magnetoresistive ring-shaped sensor can read the magnetic moments of individual commercially available paramagnetic beads using an active digital technique. This work provides proof of principle for a new approach to magnetic labeling of biomolecules for high-throughput bioassays.

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“…However, encoding with fluorescence has many problems; not least that fluorescence is one of the most common techniques used to indicate that a chemical reaction has taken place on a bead. We have recently developed a new approach to bar-coding particles based on the fabrication of micron sized diffractive elements [7]. The 'code' is read by measuring the spatial distribution of light diffracted by a pattern on the surface of a bead.…”

Section: Introductionmentioning

confidence: 99%