High-Capacity Hydrogen and Nitric Oxide Adsorption and Storage in a Metal−Organic Framework

Xiao, Bo; Wheatley, Paul; Zhao, Xuebo; Fletcher, Alan J.; Fox, Sarah; Rossi, Adriano G.; Megson, Ian L.; Bordiga, Silvia; Regli, Laura; Thomas, K. Mark; Morris, Russell E.

doi:10.1021/ja066098k

Cited by 560 publications

(491 citation statements)

References 58 publications

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“…96 MOFs consist of transition metal ions/clusters and multidentate organic ligands, and are typically synthesized via coordinationdirected self-assembly processes under mild conditions ( Figure 4). 97 Over the past two decades, MOFs have been applied in photonics, 98 catalysis, [99][100][101] biosensors, 102,103 gas storage, [104][105][106][107] and drug delivery. [108][109][110][111] For drug delivery, the high drug-loading capacity of MOFs relies largely on three factors: 1) high surface area (3,100-5,900 m 2 /g) 108 and large, regular, accessible cages and tunnels; 2) good physicochemical stability in circulation and quick stimuli 109,113 -effectively in hexane solution.…”

Section: Absorption/desorption-type Mofs As Carriersmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

419

268

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Drug molecules transformed into nanoparticles or endowed with nanostructures with or without the aid of carrier materials are referred to as “nanomedicines” and can overcome some inherent drawbacks of free drugs, such as poor water solubility, high drug dosage, and short drug half-life in vivo. However, most of the existing nanomedicines possess the drawback of low drug-loading (generally less than 10%) associated with more carrier materials. For intravenous administration, the extensive use of carrier materials might cause systemic toxicity and impose an extra burden of degradation, metabolism, and excretion of the materials for patients. Therefore, on the premise of guaranteeing therapeutic effect and function, reducing or avoiding the use of carrier materials is a promising alternative approach to solve these problems. Recently, high drug-loading nanomedicines, which have a drug-loading content higher than 10%, are attracting increasing interest. According to the fabrication strategies of nanomedicines, high drug-loading nanomedicines are divided into four main classes: nanomedicines with inert porous material as carrier, nanomedicines with drug as part of carrier, carrier-free nanomedicines, and nanomedicines following niche and complex strategies. To date, most of the existing high drug-loading nanomedicines belong to the first class, and few research studies have focused on other classes. In this review, we investigate the research status of high drug-loading nanomedicines and discuss the features of their fabrication strategies and optimum proposal in detail. We also point out deficiencies and developing direction of high drug-loading nanomedicines. We envision that high drug-loading nanomedicines will occupy an important position in the field of drug-delivery systems, and hope that novel perspectives will be proposed for the development of high drug-loading nanomedicines.

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Section: Absorption/desorption-type Mofs As Carriersmentioning

confidence: 99%

High drug-loading nanomedicines: progress, current status, and prospects

Shen

Liu

et al. 2017

IJN

419

268

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“…Good agreement has been observed between crystallographic data and pore volumes measured by gas adsorption for microporous metal organic framework materials. 59,60 In these materials, V ad is assumed to be equal to the crystallographic pore volume, which is an inherent property of the adsorbent. 61,62 However, for heterogeneous materials, such as shales, which have a wide pore size distribution, this is more problematic since adsorption in the larger pores may not be significant.…”

Section: Absolute Isotherms and Parameterizationmentioning

confidence: 99%

High-Pressure Methane Adsorption and Characterization of Pores in Posidonia Shales and Isolated Kerogens

et al. 2014

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. (2014) 'High-pressure methane adsorption and characterization of pores in Posidonia shales and isolated kerogens.', Energy fuels., 28 (5). pp. 2886-2901. Further information on publisher's website:http://dx.doi.org/10.1021/ef402466mPublisher's copyright statement:This document is the Accepted Manuscript version of a Published Work that appeared in nal form in Energy Fuels, copyright c American Chemical Society after peer review and technical editing by the publisher. To access the nal edited and published work see http://dx.doi.org/10.1021/ef402466m. Additional information:Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. AbstractSorption capacities and pore characteristics of bulk shales and isolated kerogens have been determined for immature, oil-window and gas-window mature samples from the Lower Toarcian Posidonia Shale formation. Dubinin-Radushkevich (DR) micropore volumes, sorption pore volumes and surface areas of shales and kerogens were determined from CO 2 adsorption isotherms at -78°C and 0°C, and N 2 adsorption isotherms at -196°C. Mercury injection capillary pressure porosimetry, grain density measurements and helium pycnometry were used to determine shale and kerogen densities and total pore volumes.Total porosities decrease through the oil-window and then increase into the gas-window.High-pressure methane isotherms up to 14 MPa were determined at 45, 65 and 85°C on dry shale and at 45 and 65°C on kerogen. Methane excess uptakes at 65°C and 11.5 MPa were in the range 0.056-0.110 mmol g -1 (40-78 scf t -1 ) for dry Posidonia shales and 0.36-0.70 mmol g -1 (253-499 scf t -1 ) for the corresponding dry kerogens. Absolute methane isotherms were calculated by correcting for the gas at bulk gas phase density in the sorption pore volume. The enthalpies of CH 4 adsorption for shales and kerogens at zero surface coverage showed no significant variation with maturity, indicating that the sorption pore volume is the primary control on sorption uptake. The sum of pore volumes measured by a) CO 2 sorption at -78°C and b) mercury injection, are similar to the total porosity for shales. Since mercury in our experiments occupies pores with constrictions larger than ca. 6 nm, we infer that porosity measured by CO 2 adsorption at -78°C in the samples used in this study is largely within pores with effective diameters smaller than 6 nm. The linear correlation between maximum CH 4 surface excess sorption and CO 2 sorption pore volume at -78°C is very strong for both shales and kerogens, and goes through the origin, suggestin...

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“…Particularly, metal organic frameworks (MOFs) have generated large interest owing to their versatile architectures [35] and their promising applications not only in ion exchange, adsorption and gas storage [36][37][38][39][40][41], separation processes [42], heterogeneous catalysis [43,44], polymerization reactions [45,46], luminescence [47], non-linear optics [48] and magnetism [49], but also as drug carriers, systems for drug delivery [22,23,50,51], contrast agents for magnetic resonance imaging (MRI) [21] and systems with potential use in other biomedical applications [23].…”

Section: Introductionmentioning

confidence: 99%

Bio-Inspired Metal-Organic Frameworks in the Pharmaceutical World: A Brief Review

André¹,

Quaresma²

2016

Metal-Organic Frameworks

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One of the great challenges in the pharmaceutical industry is the search for more efficient and cost-effective ways to store and deliver existing drugs. Bio-inspired metalorganic frameworks (BioMOFs) are groundbreaking materials that have recently been explored for drug storage, delivery and controlled release as well as for applications in imaging and sensing for therapeutic and diagnostic. This review presents a brief overview on these materials, and by alluding to a few reported examples, it intends to clearly show the extremely important role that BioMOFs have been playing in the pharmaceutical field.

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High-Capacity Hydrogen and Nitric Oxide Adsorption and Storage in a Metal−Organic Framework

Cited by 560 publications

References 58 publications

High drug-loading nanomedicines: progress, current status, and prospects

High drug-loading nanomedicines: progress, current status, and prospects

High-Pressure Methane Adsorption and Characterization of Pores in Posidonia Shales and Isolated Kerogens

Bio-Inspired Metal-Organic Frameworks in the Pharmaceutical World: A Brief Review

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