High C‐reactive protein levels are associated with oral hormonal menopausal therapy but not with intrauterine levonorgestrel and transdermal estradiol

Blumenfeld, Zeev; Boulman, Nina; Leiba, Ronit; Siegler, Efraim; Shachar, Shlomit Strulov; Linn, Ran; Levy, Yishai

doi:10.1080/00365510601113241

Cited by 15 publications

(5 citation statements)

References 35 publications

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“…These observations are consistent with the current literature (3, 9, 27). Baseline concentrations of CRP in the HRT group were significantly correlated with body mass index, waist circumference, systolic blood pressure and fasting triglycerides.…”

Section: Discussionsupporting

confidence: 94%

Effects of Different Doses of Physical Activity on C-Reactive Protein among Women

Stewart

Earnest

Blair

et al. 2010

Medicine &Amp; Science in Sports &Amp; Exercise

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Elevated C-reactive protein (CRP) is associated with an increased risk of cardiovascular disease. Physical activity has been inversely associated with CRP. However, the clinical trials examining the effect of exercise training have produced conflicting results.Purpose-The purpose of this study was to examine the influence an exercise training program on CRP in postmenopausal women.Methods-Sedentary, overweight/obese, postmenopausal women with elevated systolic blood pressure (120.0 to 159.9 mm Hg) (N= 464) were randomized into 1 of 4 groups: a non-exercise control or 1 of 3 aerobic exercise groups; exercise energy expenditure of 4, 8, or 12 kcal/kg/week (KKW), for 6 months at a training intensity of 50% of peak VO 2 .Results-Complete data was available of 421 participants and mean baseline CRP was 5.7 (5.5) mg/L with no significant differences across groups. While VO 2 increased in a dose response manner, there were no significant changes in CRP in any of the exercise intervention groups compared to the control group. Change in fitness was not associated with change in CRP, whereas change in weight was significantly associated with change in CRP.Conclusion-Despite increasing fitness, six months of aerobic exercise training did not improve CRP. However, improvements in CRP were associated with reductions in weight.

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Section: Discussionsupporting

confidence: 94%

Effects of Different Doses of Physical Activity on C-Reactive Protein among Women

Stewart

Earnest

Blair

et al. 2010

Medicine &Amp; Science in Sports &Amp; Exercise

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“…42,43 Our previous demonstration of an association between tobacco smoking and increased risk for major depressive disorder 42 may have a multifactorial basis including dysregulation of the dopaminergic system 44 and offers further support to an inflammation-based aetiology, as smoking induces an inflammatory response. 45 Non-steroidal anti-inflammatory drugs and both oral contraceptives and oral hormone therapy have an impact on circulating levels of CRP 30,46 and our findings corroborate these reports. Childhood maltreatment predisposes to depression and may play a role in increasing the risk for inflammation in adulthood; 47,48 this has not been entered into the models, as these data were not available.…”

Section: Discussiongsupporting

confidence: 89%

Association of high-sensitivity C-reactive protein with de novo major depression

et al. 2010

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“…In addition to the fact that its corrective effects on estrogen decrease over time, postmenopausal hormone therapy is known to cause inflammation and liver damage in women (44,46,47). To prevent the deleterious effects of estrogen, androgen therapy is now a promising treatment for preventing menopausal problems in women, such as dyslipidemia, inflammation, and decreased libido (48)(49)(50).…”

Section: Discussionmentioning

confidence: 99%

Sumoylated PPARα mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice

Leuenberger¹,

Pradervand²,

Wahli³

2009

J. Clin. Invest.

102

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As most metabolic studies are conducted in male animals, understanding the sex specificity of the underlying molecular pathways has been broadly neglected; for example, whether PPARs elicit sex-dependent responses has not been determined. Here we show that in mice, PPARα has broad female-dependent repressive actions on hepatic genes involved in steroid metabolism and immunity. In male mice, this effect was reproduced by the administration of a synthetic PPARα ligand. Using the steroid oxysterol 7α-hydroxylase cytochrome P450 7b1 (Cyp7b1) gene as a model, we elucidated the molecular mechanism of this sex-specific PPARα-dependent repression. Initial sumoylation of the ligand-binding domain of PPARα triggered the interaction of PPARα with GA-binding protein α (GABPα) bound to the target Cyp7b1 promoter. Histone deacetylase and DNA and histone methylases were then recruited, and the adjacent Sp1-binding site and histones were methylated. These events resulted in loss of Sp1-stimulated expression and thus downregulation of Cyp7b1. Physiologically, this repression conferred on female mice protection against estrogen-induced intrahepatic cholestasis, the most common hepatic disease during pregnancy, suggesting a therapeutic target for prevention of this disease.

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High C‐reactive protein levels are associated with oral hormonal menopausal therapy but not with intrauterine levonorgestrel and transdermal estradiol

Cited by 15 publications

References 35 publications

Effects of Different Doses of Physical Activity on C-Reactive Protein among Women

Effects of Different Doses of Physical Activity on C-Reactive Protein among Women

Association of high-sensitivity C-reactive protein with de novo major depression

Sumoylated PPARα mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice

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