High C-reactive protein and low cholesterol levels are prognostic markers of survival in severe sepsis

Memiş, Dilek; Gursoy, Olcay; Tasdogan, M; Süt, Necdet; Kurt, İmran; Türe, Mevlüt; Karamanlıoğlu, Beyhan

doi:10.1016/j.jclinane.2006.10.008

Cited by 40 publications

(49 citation statements)

References 35 publications

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“…Several studies have been performed to investigate potential prognostic markers in dogs infected with CPV, which include endocrine, 13 hematologic, 14 and biochemical variables. 7,15 In human patients with severe sepsis, mortality rates may exceed 30%, despite advanced supportive care 16 ; these results are similar to those of studies in which mortality rates of 15% 17 to 53% 15 were found for parvovirus-infected puppies that received aggressive supportive care. Associations between serum concentrations of CRP, a major APP in humans and dogs, and survival have been investigated in humans with severe sepsis.…”

Section: Small Animals/ Exoticsupporting

confidence: 74%

“…During the past 20 years, much research has been done to find ways of improving the precision and accuracy of clinicians' estimates. 16 Results of the study reported here indicate that the use of serum CRP concentration alone to make decisions about outcome is not reliable, but serial measurements of serum CRP may prove useful to monitor the progression of the disease and adapt treatment accordingly. Future studies are warranted to evaluate serial CRP concentrations in conjunction with other variables proven to be of value in prognostication for dogs with CPV infection, such as leukocyte count and results of serum biochemical and endocrine hormone analysis.…”

Section: Discussionmentioning

confidence: 83%

“…Associations between serum concentrations of CRP, a major APP in humans and dogs, and survival have been investigated in humans with severe sepsis. 16 Median serum CRP concentrations were significantly higher in nonsurvivors, compared with the survivors, indicating that CRP concentration could be used as a predictor of outcome in human patients with sepsis. 16 In dogs, CRP is primarily produced in the liver by de novo synthesis and released into the bloodstream following stimulation by proinflammatory cytokines.…”

Section: Small Animals/ Exoticmentioning

confidence: 90%

“…16 Median serum CRP concentrations were significantly higher in nonsurvivors, compared with the survivors, indicating that CRP concentration could be used as a predictor of outcome in human patients with sepsis. 16 In dogs, CRP is primarily produced in the liver by de novo synthesis and released into the bloodstream following stimulation by proinflammatory cytokines. 16,18 The extent of changes in circulating CRP concentrations during the course of disease seems to reflect underlying disease progression and inflammatory activity.…”

Section: Small Animals/ Exoticmentioning

confidence: 90%

“…16 In dogs, CRP is primarily produced in the liver by de novo synthesis and released into the bloodstream following stimulation by proinflammatory cytokines. 16,18 The extent of changes in circulating CRP concentrations during the course of disease seems to reflect underlying disease progression and inflammatory activity.…”

Section: Small Animals/ Exoticmentioning

confidence: 99%

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Evaluation of the use of serum C-reactive protein concentration to predict outcome in puppies infected with canine parvovirus

McClure¹,

Schoor²,

Thompson³

et al. 2013

javma

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Objective—To evaluate associations of serum C-reactive protein (CRP) concentration with duration of hospitalization and with outcome in puppies with canine parvoviral enteritis. Design—Prospective observational study. Animals—79 client-owned puppies with naturally acquired canine parvovirus infection. Procedures—All puppies received supportive care. Serum CRP concentration was measured at the time of admission, approximately every 10 to 12 hours for the first 48 hours, and then every 24 hours until discharge from the hospital or death. Associations between outcome and CRP concentration at various time points or changes in CRP concentration over time were assessed via multiple logistic regression. Associations of CRP concentration with survival time and duration of hospitalization among survivors were estimated with Cox proportional hazards regression. Use of CRP concentration to predict outcome was evaluated by means of receiver operating characteristic curve analysis. Results—Serum CRP concentrations at admission and 12 and 24 hours later were positively associated with odds of death, and CRP concentrations at 12 and 24 hours after admission were negatively associated with survival time for puppies. Among survivors, duration of hospitalization was positively associated with CRP concentrations at 12, 24, and 36 hours after admission. Sensitivity and specificity of CRP concentration to differentiate between survivors and nonsurvivors at 24 hours after admission were 86.7% and 78.7%, respectively (considered moderately accurate). Conclusions and Clinical Relevance—Although serum CRP concentration was associated with outcome in puppies with canine parvovirus enteritis, it did not prove to be a good predictor of outcome when used alone.

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Section: Small Animals/ Exoticsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 83%

Section: Small Animals/ Exoticmentioning

confidence: 90%

Section: Small Animals/ Exoticmentioning

confidence: 90%

Section: Small Animals/ Exoticmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of the use of serum C-reactive protein concentration to predict outcome in puppies infected with canine parvovirus

McClure¹,

Schoor²,

Thompson³

et al. 2013

javma

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A metabonomic approach to early prognostic evaluation of experimental sepsis by ¹H NMR and pattern recognition

Lin

Yan

et al. 2009

NMR in Biomedicine

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This study proposes an NMR-based metabonomic approach to early prognostic evaluation of sepsis. Forty septic rats receiving cecal ligation and puncture (CLP) were divided into the surviving group and nonsurviving group on day 6, while 20 sham-operated rats served as the control group. Serum samples were collected from septic and sham-operated rats at 12 h after surgery and analyzed using (1)H NMR spectroscopy. Orthogonal partial least squares (OPLS) were applied and showed clustering according to predefined groups, indicating that NMR-based metabolic profiling could reveal pathologic characteristics in the serum of sham-operated, surviving, and nonsurviving septic rats. In addition, six characteristic metabolites including lactate, alanine, acetate, acetoacetate, hydroxybutyrate, and formate, which are mainly involved in energy metabolism, changed markedly in septic rats, especially in the nonsurvivors. Using these metabolites, a predictive model for prognostic evaluation of sepsis was constructed using a radial basis function neural network (RBFNN) with a prediction accuracy of about 87% by test samples. The results indicated that the NMR-based metabonomic approach is a potential technique for the early prognostic evaluation of sepsis.

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Gluco- and mineralocorticoid biological effects of a 7-day treatment with low doses of hydrocortisone and fludrocortisone in septic shock

et al. 2012

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High C-reactive protein and low cholesterol levels are prognostic markers of survival in severe sepsis

Cited by 40 publications

References 35 publications

Evaluation of the use of serum C-reactive protein concentration to predict outcome in puppies infected with canine parvovirus

Evaluation of the use of serum C-reactive protein concentration to predict outcome in puppies infected with canine parvovirus

A metabonomic approach to early prognostic evaluation of experimental sepsis by ¹H NMR and pattern recognition

Gluco- and mineralocorticoid biological effects of a 7-day treatment with low doses of hydrocortisone and fludrocortisone in septic shock

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High C-reactive protein and low cholesterol levels are prognostic markers of survival in severe sepsis

Cited by 40 publications

References 35 publications

Evaluation of the use of serum C-reactive protein concentration to predict outcome in puppies infected with canine parvovirus

Evaluation of the use of serum C-reactive protein concentration to predict outcome in puppies infected with canine parvovirus

A metabonomic approach to early prognostic evaluation of experimental sepsis by 1H NMR and pattern recognition

Gluco- and mineralocorticoid biological effects of a 7-day treatment with low doses of hydrocortisone and fludrocortisone in septic shock

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A metabonomic approach to early prognostic evaluation of experimental sepsis by ¹H NMR and pattern recognition