High- but not low-grade histologic chorioamnionitis is associated with spontaneous preterm birth in a Swedish cohort

Fahmi, Selma; Papadogiannakis, Nikos; Nasiell, Josefine

doi:10.1080/14767058.2017.1340447

Cited by 6 publications

(6 citation statements)

References 24 publications

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“…Moreover, it has been found that high‐grade chorioamnionitis is over‐represented in stillborn term placentas and early preterm pregnancy compared to healthy controls , whereas low‐grade chorioamnionitis may be part of physiologic mechanism(s) in term pregnancy . In the present study, we find in the multivariate model an association between delivery at home and low‐grade chorioamnionitis.…”

Section: Discussionsupporting

confidence: 54%

Placental inflammation, lifestyle, maternal and early child sensitisation to allergens – the assessment of lifestyle and allergic disease during infancy birth cohort

et al. 2018

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Aim: To investigate (i) whether maternal sensitisation to allergens, and lifestyle can influence the risk of acute and chronic inflammation of the placenta, in the forms of chorioamnionitis and villitis, respectively, and (ii) whether these placental inflammations are associated with the outcome of sensitisation for the child during preschool age.Methods: Placentas from term uncomplicated pregnancies (n = 275) in the assessment of lifestyle and allergic disease during infancy study were analysed for the presence of acute chorioamnionitis and chronic villitis. Stepwise logistic regression was performed to estimate the relative risk of placental inflammation in relation to maternal allergic sensitisation and lifestyle, and the association between placental inflammation and sensitisation of the child up to five years of age.Results: Parity and delivery at home were independently associated with chorioamnionitis, home delivery only with the low grade. Maternal allergic sensitisation was associated with increased risk of villitis in the bivariable model, however, not in the multivariable model. No significant associations were detected between placental inflammation and the outcome of sensitisation to allergens at five years of age. Conclusion:Our data do not support the hypothesis that the increased risk for sensitisation of a child when the mother is allergic is mediated via placental inflammation.

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Section: Discussionsupporting

confidence: 54%

Placental inflammation, lifestyle, maternal and early child sensitisation to allergens – the assessment of lifestyle and allergic disease during infancy birth cohort

et al. 2018

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“…Recent research has solidified our understanding of the significant contribution of the paternal parent to placental development in women and mice [8, 15-18, 58, 59]. Moreover, placental inflammation is an important determinant of the timing of parturition [38,60]; not surprisingly, premature placental inflammation has been associated with PTB [8,61,62]. Using a murine model, we previously found that premature placental inflammation and PTB frequently occur in association with a paternal history of developmental exposure to TCDD [8,9], a common environmental contaminant associated with combustion and known endocrine disruptor.…”

Section: Discussionmentioning

confidence: 99%

Paternal developmental toxicant exposure is associated with epigenetic modulation of sperm and placentalPgrandIgf2in a mouse model†

Ding

Mokshagundam

Rinaudo

et al. 2018

Biology of Reproduction

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Preterm birth (PTB), parturition prior to 37 weeks' gestation, is the leading cause of neonatal mortality. The causes of spontaneous PTB are poorly understood; however, recent studies suggest that this condition may arise as a consequence of the parental fetal environment. Specifically, we previously demonstrated that developmental exposure of male mice (F1 animals) to the environmental endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was associated with reduced sperm quantity/quality in adulthood and control female partners frequently delivered preterm. Reproductive defects persisted in the F2 and F3 descendants, and spontaneous PTB was common. Reproductive changes in the F3 males, the first generation without direct TCDD exposure, suggest the occurrence of epigenetic alterations in the sperm, which have the potential to impact placental development. Herein, we conducted an epigenetic microarray analysis of control and F1 male-derived placentae, which identified 2171 differentially methylated regions, including the progesterone receptor (Pgr) and insulin-like growth factor (Igf2). To assess if Pgr and Igf2 DNA methylation changes were present in sperm and persist in future generations, we assessed methylation and expression of these genes in F1/F3 sperm and F3-derived placentae. Although alterations in methylation and gene expression were observed, in most tissues, only Pgr reached statistical significance. Despite the modest gene expression changes in Igf2, offspring of F1 and F3 males consistently exhibited IUGR. Taken together, our data indicate that paternal developmental TCDD exposure is associated with transgenerational placental dysfunction, suggesting epigenetic modifications within the sperm have occurred. An evaluation of additional genes and alternative epigenetic mechanisms is warranted.

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“…In recent years, increasing evidence indicated that there is a strong positive correlation between the infections in the genitourinary tract and the incidence of preterm birth, which consequentially lead to the preterm birth . Chorioamnionitis is one of the most common types of infections in the genitourinary tract during the period of pregnancy, and chorioamnionitis is also one of the leading causes of preterm birth . Results from previous studies indicated that if no proper medical interventions were made at the early stage of chorioamnionitis, premature delivery of the babies from mothers with chorioamnionitis can lead to short‐term and long‐term complications, that is, bronchopulmonary dysplasia (BPD), cerebral palsy (CP), and early‐onset sepsis (EOS) .…”

Section: Introductionmentioning

confidence: 99%

Maternal peripheral blood platelet‐to‐white blood cell ratio and platelet count as potential diagnostic markers of histological chorioamnionitis‐related spontaneous preterm birth

Li-yin

Pan

Rong-lian

et al. 2019

Clinical Laboratory Analysis

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Background Histological chorioamnionitis (HCA) is one of the leading causes of spontaneous preterm birth, thus, to identify novel biomarkers for the early diagnosis of HCA is in a great need. Objective To investigate the diagnostic value of maternal peripheral blood platelet‐to‐white blood cell ratio (PLT/WBC) and platelet (PLT) counts in HCA‐related preterm birth. Methods A total of 400 patients with preterm birth were enrolled in this study: non‐HCA group (n = 193) and HCA group (n = 207), and 87 full‐term pregnancies were enrolled as the control. The peripheral blood of the participators was collected, and the neutrophil count, WBC count, platelet count, and levels of C‐reactive protein (CRP) and procalcitonin were recorded, and the platelet‐to‐white blood cell ratio (PLT/WBC) of the participators was calculated. Receiver operating characteristic (ROC) curve has been drawn to show the sensitivity and specificity of PLT/WBC and PLT count for the diagnosis of HCA‐related spontaneous preterm birth patients. Results The neutrophil count, WBC count, and procalcitonin show no significant differences among the three groups, and the PLT count, PLT/WBC, and CRP (P < 0.05) were significantly increased in HCA group compared with non‐HCA group; moreover, the area under the curve (AUC) of PLT/WBC, PLT, and CRP was 0.744 (95% confidence interval [CI], 0.6966‐0.7922), 0.8095 (95% CI, 0.7676‐0.8514), and 0.5730 (95% CI, 0.5173‐0.6287), respectively. Conclusion Platelet count and PLT/WBC may become a potential biomarker of HCA‐related spontaneous preterm birth.

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High- but not low-grade histologic chorioamnionitis is associated with spontaneous preterm birth in a Swedish cohort

Abstract: Despite a relatively low incidence of HCA in the preterm groups, HCA 2 seems to be associated with early preterm birth whereas HCA 1 seems to be part of the full-term delivery.

Cited by 6 publications

References 24 publications

Placental inflammation, lifestyle, maternal and early child sensitisation to allergens – the assessment of lifestyle and allergic disease during infancy birth cohort

Placental inflammation, lifestyle, maternal and early child sensitisation to allergens – the assessment of lifestyle and allergic disease during infancy birth cohort

Paternal developmental toxicant exposure is associated with epigenetic modulation of sperm and placentalPgrandIgf2in a mouse model†

Maternal peripheral blood platelet‐to‐white blood cell ratio and platelet count as potential diagnostic markers of histological chorioamnionitis‐related spontaneous preterm birth

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