High burden of coronary atherosclerosis in patients with a new diagnosis of type 2 diabetes

Mrgan, Monija; Funck, Kristian Løkke; Gaur, Sara; Øvrehus, Kristian Altern; Dey, Damini; Kusk, Martin Weber; Nørgaard, Bjarne Linde; Gram, Jørgen Brodersen; Olsen, Michael Hecht; Gram, Jeppe; Sand, Niels Peter Rønnow

doi:10.1177/1479164117728014

Cited by 13 publications

(19 citation statements)

References 40 publications

(60 reference statements)

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“…Elevated blood glucose level combined with dyslipidemia increases atherosclerosis-related inflammation and makes it more extensive [ 41 ]. A larger extent of coronary artery calcification in asymptomatic patients with newly-diagnosed T2DM has been demonstrated [ 42 ]. Dyslipidemia is not only an important risk for macrovascular complications [ 43 ]; studies have also observed the association of dyslipidemia with microvascular complications related to T2DM namely diabetic retinopathy, diabetic nephropathy and diabetic neuropathy [ 44 , 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

Serum Lipid Profile and Its Association with Diabetes and Prediabetes in a Rural Bangladeshi Population

Bhowmik

Siddiquee²,

Mujumder³

et al. 2018

IJERPH

124

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Dyslipidemia is commonly associated with diabetes (T2DM). This has been demonstrated for the Caucasian population, but few data are available for Asian Indians. The paper aims to investigate serum lipids (separately or in combination) and their association with glucose intolerance status (T2DM and prediabetes) in a rural Bangladeshi population. A sample of 2293 adults (≥20 years) were included in a community based cross-sectional survey in 2009. Anthropometric measures, blood pressure, blood glucose (fasting and 2-h oral glucose tolerance test) and fasting serum lipids (total cholesterol, T-Chol; triglycerides, Tg; low density lipoprotein cholesterol, LDL-C and high density lipoprotein cholesterol, HDL-C) were registered. Analysis of covariance (ANCOVA) and regression analysis were performed. High Tg levels were seen in 26% to 64% of the participants, depending on glucose tolerance status. Low HDL-C levels were seen in all groups (>90%). Significant linear trends were observed for high T-Chol, high Tg and low HDL-C with increasing glucose intolerance (p for trend <0.001). T2DM was significantly associated with high T-Chol (Odds ratio (OR): 2.43, p < 0.001), high Tg (OR: 3.91, p < 0.001) and low HDL-C (OR: 2.17, p = 0.044). Prediabetes showed a significant association with high Tg (OR: 1.96, p < 0.001) and low HDL-C (OR: 2.93, p = 0.011). Participants with combined high Tg and low HDL-C levels had a 12.75-fold higher OR for T2DM and 4.89 OR for prediabetes. In Asian Indian populations an assessment of serum lipids is warranted not only for T2DM patients, but also for those with prediabetes.

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Section: Discussionmentioning

confidence: 99%

Serum Lipid Profile and Its Association with Diabetes and Prediabetes in a Rural Bangladeshi Population

Bhowmik

Siddiquee²,

Mujumder³

et al. 2018

IJERPH

124

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“…16 Arterial thickening/hardening of the arteries or plaque makes the blood flow reduction , reducing the supply of oxygen and nutrients to the leg muscles. [17][18][19][20] Tissue necrosis can occur due to reduced blood flow, hypoxia, so that infection and gangrene can occur and that may lead to amputation. 21…”

Section: Itemsmentioning

confidence: 99%

Relationship of visual impairment and peripheral artery disease with the occurrence of diabetic foot ulcers in Dr. Moewardi Hospital

Purwanti

Yetti

Herawati

2019

Frontiers of Nursing

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Objective: One of the diabetes mellitus (DM) complications is foot ulcers. Foot ulcers are influenced by many factors. DM puts patients at risk of injury because of visual impairment. Hyperglycemia can damage blood vessels, which results in peripheral artery disease (PAD). The purpose of this study was to find the relationship of visual impairment and PAD with diabetic foot ulcers. Methods: This research used observational analytic study with case-control methods. It used purposive sampling in 34 DM patients with foot ulcers and 34 DM patients without foot ulcers. The research instruments were an interview guide to assess visual impairment, physical examination to assess PAD, and documentation study, which was used to know the incidence of diabetic ulcers. Results: The results showed that the respondents who experienced ulcers with visual impairment were 44.1% and the respondents who had foot ulcers with PAD were 73.5%. The results of statistical tests showed that there was no relationship between visual impairment and the incidence of ulcers (P = 0.166). The respondents with PAD will have a chance to suffer from foot ulcers 5.808 times higher than those who do not have PAD. Conclusions:There is no relationship between visual impairment and the incidence of diabetic foot ulcers in Dr. Moewardi Hospital, but there is relationship between PAD and the incidence of diabetic foot ulcers in Dr. Moewardi Hospital. Suggestions of this study are to do foot screening and educate about the importance of foot care to prevent the occurrence of diabetic ulcers.

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“…In terms of plaque constitution, previous studies reported that 34% and 41% of plaques were classified as noncalcified plaque, proportions that are higher than those of 21% and 24% in nondiabetic patients [ 6 13 14 ]. These noncalcified plaques were associated with a family history of diabetes, and newly diagnosed patients tended to have a large volume of noncalcified plaque, especially patients with asymptomatic diabetes [ 15 16 ]. Asymptomatic diabetic patients therefore appear to have a relatively high prevalence of noncalcified plaques, with these being mainly nonobstructive.…”

Section: The Characteristics Of Coronary Atherosclerosismentioning

confidence: 99%

“…Diabetic patients are characterized by the presence of an accelerated progressive atheroma burden with a significantly increased incidence of CV events [ 20 ]. A recent study reported that asymptomatic patients with newly diagnosed diabetes had plaque features associated with increased vulnerability [ 16 ], a finding that indicates that early-stage diabetic patients constitute an important therapeutic target for the prevention of future CV events. Several studies have investigated the predictors of atherosclerosis progression and the impact of atherosclerosis progression on CV events in diabetic patients.…”

Section: Progression and Predictors Of Subclinical Coronary Atherosclmentioning

confidence: 99%

Diabetes and Subclinical Coronary Atherosclerosis

Lee

Park

2018

Diabetes Metab J

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It is well known that diabetic patients have a high risk of cardiovascular events, and although there has been a tremendous effort to reduce these cardiovascular risks, the incidence of cardiovascular morbidity and mortality in diabetic patients remains high. Therefore, the early detection of coronary artery disease (CAD) is necessary in those diabetic patients who are at risk of cardiovascular events. Significant medical and radiological advancements, including coronary computed tomography angiography (CCTA), mean that it is now possible to investigate the characteristics of plaques, instead of solely evaluating the calcium level of the coronary artery. Recently, several studies reported that the prevalence of subclinical coronary atherosclerosis (SCA) is higher than expected, and this could impact on CAD progression in asymptomatic diabetic patients. In addition, several reports suggest the potential benefit of using CCTA for screening for SCA in asymptomatic diabetic patients, which might dramatically decrease the incidence of cardiovascular events. For these reasons, the medical interest in SCA in diabetic patients is increasing. In this article, we sought to review the results of studies on CAD in asymptomatic diabetic patients and discuss the clinical significance and possibility of using CCTA to screen for SCA.

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High burden of coronary atherosclerosis in patients with a new diagnosis of type 2 diabetes

Abstract: Asymptomatic patients with newly diagnosed type 2 diabetes had plaque features associated with increased vulnerability as compared with age- and sex-matched controls.

Cited by 13 publications

References 40 publications

Serum Lipid Profile and Its Association with Diabetes and Prediabetes in a Rural Bangladeshi Population

Serum Lipid Profile and Its Association with Diabetes and Prediabetes in a Rural Bangladeshi Population

Relationship of visual impairment and peripheral artery disease with the occurrence of diabetic foot ulcers in Dr. Moewardi Hospital

Diabetes and Subclinical Coronary Atherosclerosis

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