High body mass index is associated with an increased overall survival in rectal cancer

Juszczyk, Karolina; Kang, Sharlyn; Putnis, Soni; Winn, Robert; Chen, James; Aghmesheh, Morteza; Fylyk, Glaucia; Brungs, Daniel

doi:10.21037/jgo-20-48

Cited by 6 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another study, which included only local advanced rectal cancer (LARC) patients, stated that underweight was an independent risk factor for OS and cancer-specific survival (CSS). Additionally, one study reported that BMI ≥ 25 was significantly correlated with greater OS compared to BMI < 25 [ 12 ]. Although focusing on different colorectal cancer patients, these results were similar to our results.…”

Section: Discussionmentioning

confidence: 99%

“…These studies mainly revealed that increased BMI or obesity was associated with a higher local recurrence (LR) rate [10,11]. However, another study demonstrated that the OS of overweight/obese patients was significantly better than that of underweight/normal-weight patients [12]. Meanwhile, other studies reported that lower BMI or underweight was associated with poorer overall survival (OS) [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of BMI on long-term outcome in patients with rectal cancer and establishment of a nomogram prediction model

et al. 2023

View full text Add to dashboard Cite

Background The effects of body mass index (BMI) in patients with rectal cancer have been poorly studied and are still controversial. In this study, we aimed to assess the effect of BMI on the long-term outcome in patients with rectal cancer after radical surgery. Materials and methods Between April 2012 and December 2020, patients who received total mesorectal excision (TME) surgery were enrolled in the study. Patients were divided into four groups according to BMI level. Kaplan–Meier survival curves with log-rank tests were used to analyze overall survival (OS), Disease-free survival (DFS), local recurrence-free survival and distant metastasis-free survival. Univariate and multivariate analyses were performed to identify the risk factors associated with the long-term outcome. Nomograms were developed to predict the OS and DFS based on independent prognostic factors. Results A total of 688 patients were included in this study. The median follow-up time was 69 months. The 5-year OS rates of the control, underweight, overweight and obese groups were 79.2%, 62.2%, 88.7% and 86.3%, respectively. The 5-year DFS rates were 74.8%, 58.2%, 80.5% and 81.4%, respectively. Overweight (HR 0.534; 95% CI 0.332–0.860, p = 0.010) was an independent protective factor for OS and DFS (HR 0.675; 95% CI 0.461–0.989, p = 0.044). Underweight was an independent risk factor for DFS (HR = 1.623; 95% CI 1.034–2.548; p = 0.035), and had a trend to be an independent risk factor for OS (HR 1.594; 95% 0.954–2.663; p = 0.075). Nomograms were established to predict the 2-year OS, 5-year OS, 2-year DFS and 5-year DFS with an area under curve (AUC) of 0.767, 0.712, 0.746 and 0.734, respectively. Conclusions For rectal cancer patients after radical surgery, overweight was an independent protective factor for OS and DFS. Underweight was an independent risk factor for DFS and had a trend to be an independent risk factor for OS. Nomograms incorporating BMI and other prognostic factors could be helpful to predict long-term outcome.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effect of BMI on long-term outcome in patients with rectal cancer and establishment of a nomogram prediction model

et al. 2023

View full text Add to dashboard Cite

show abstract

“… 35 Daniel’s team found that BMI is a key factor affecting the prognosis of rectal cancer patients, wherein BMI >25 kg/m2 is significantly correlated with longer OS and Cancer specific survival. 36 …”

Section: Discussionmentioning

confidence: 99%

“…35 Daniel's team found that BMI is a key factor affecting the prognosis of rectal cancer patients, wherein BMI >25 kg/m2 is significantly correlated with longer OS and Cancer specific survival. 36 Pathologic complete response is defined as the highest efficacy of neoadjuvant treatment at the time of surgery, and pCR represents an essential evaluation for NAT outcome. 34 In this study, 10.8% (30/277) of patients acquired pCR during preoperative treatment.…”

Section: Discussionmentioning

confidence: 99%

Weight Loss During Neoadjuvant Therapy Is Associated With Poor Response Among the Patients With Gastrointestinal Cancer: A Propensity Score Matching Analysis

Jiang

Luo

et al. 2023

Cancer Control

View full text Add to dashboard Cite

Purpose The aim of the current study was to identify the relationship between body composition changes during neoadjuvant therapy (NAT) and the treatment efficiency of NAT in gastrointestinal cancer (GC) patients. Methods From January 2015 to July 2020, 277 GC patients treated with NAT had included for retrospective analysis. The body mass index (BMI) and computed tomography (CT) imaging before and after NAT were recorded. The BMI change optimal cut-off value were calculated by ROC curve. Balancing essential characteristic variables using propensity score matching (PSM) method. Exploring the association between BMI changes and tumor response to NAT using logistic regression analysis. The survival outcome of matched patients between different BMI change groups was compared. Results A cutoff point of BMI change >2% during NAT was defined as BMI loss. Among the 277 patients, 110 (39.7%) patients showed BMI change with a loss after NAT. In total, 71 pairs of patients were selected for further analysis. The median follow-up time was 22 months (range 3 to 63 months). Univariate and multivariate logistic regression analyses in matched cohort showed that BMI change was a prognostic factor for tumor response after NAT in GC patients (odds ratio (OR), .471; 95% confidence interval (CI), .233-.953; P = .036). In addition, patients who experienced BMI loss after NAT showed worse overall survival than those who had BMI gain or stable. Conclusion BMI loss during NAT probably may has negative effects on NAT efficiency and survival for gastrointestinal cancer patients. It is necessary to monitor and maintain weight for patients during treatment.

show abstract

“…Malnutrition is a frequent problem in cancer patients, and preoperative nutritional status has been found to be correlated with outcomes in patients with malignancies (2). Body mass index (BMI) is one of the preoperative nutritional parameters and has been found to be correlated with the survival of patients with various carcinomas (3)(4)(5)(6). It has been reported that a lower BMI increases the risk of developing ESCC (7).…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of Body Mass Index Stratified by Alcohol Drinking Status in Patients With Esophageal Squamous Cell Carcinoma

2022

View full text Add to dashboard Cite

BackgroundThe goal of this study was to investigate the prognostic value of body mass index (BMI) in patients with esophageal squamous cell carcinoma (ESCC) when stratified by alcohol drinking status.MethodsA total of 620 patients with ESCC who underwent esophagectomy were analyzed. A receiver operating characteristic curve was constructed to set the appropriate cutoff point for BMI. Alcohol drinking was divided into ever and never. Kaplan-Meier and multivariate Cox regression analyses were conducted to investigate the association between clinicopathological factors and survival.ResultsThe cutoff point was 18.75 kg/m2 for BMI. Two hundred and twenty-nine patients were ever drinkers, while the other 391 patients were never drinkers. The ever drinker group was found to have more males, longer tumor lengths, advanced pT category disease, advanced pN category disease, and lower tumor locations. However, no significant difference in BMI was found between ever drinkers and never drinkers. For ever drinkers, low BMI was significantly correlated with worse overall survival (hazard ratio = 1.690; P=0.035) and cancer-specific survival (hazard ratio = 1.763; P=0.024) than high BMI after adjusting for other factors. However, BMI was not a prognostic factor in univariate and multivariate analyses for never drinkers.ConclusionsBMI is a prognostic factor only in ever drinkers with ESCC but not in never drinkers. Further studies are needed to elucidate the mechanism underlying the effect of the interaction between BMI and alcohol consumption on the prognosis of patients with ESCC.

show abstract

High body mass index is associated with an increased overall survival in rectal cancer

Cited by 6 publications

References 22 publications

The effect of BMI on long-term outcome in patients with rectal cancer and establishment of a nomogram prediction model

The effect of BMI on long-term outcome in patients with rectal cancer and establishment of a nomogram prediction model

Weight Loss During Neoadjuvant Therapy Is Associated With Poor Response Among the Patients With Gastrointestinal Cancer: A Propensity Score Matching Analysis

Prognostic Value of Body Mass Index Stratified by Alcohol Drinking Status in Patients With Esophageal Squamous Cell Carcinoma

Contact Info

Product

Resources

About