Abstract:Psoriasis is associated with being overweight, but the temporal relationship is not known. This historical cohort study tested whether severe psoriasis resulting in hospitalization in adulthood was preceded by excess increase in age-adjusted body mass index, a known risk factor in childhood for being overweight in adulthood. The study cohort was based on the Copenhagen School Health Records Register, birth years 1930 to 1984 (309,152 schoolchildren). Cases were found through the Danish National Patient Registe… Show more
“…[6][7][8][9][10][11][12][13]15 Obesity apparently predisposes to the development of psoriasis and vice versa, although there is less evidence for the latter. [6][7][8][9][10][11][12][13]15 Two studies have provided results suggesting that patients with psoriasis gain weight after the onset of the condition. Herron et al 32 presented retrospective data from 557 patients with psoriasis and concluded that obesity did not seem to have a role in the onset of psoriasis.…”
Section: Discussionmentioning
confidence: 99%
“…[4][5][6] In addition, epidemiological studies have established that psoriasis is associated with obesity and that increased adiposity and weight gain are risk factors for incident psoriasis. [6][7][8][9][10][11][12][13][14][15] Like psoriasis, obesity is accompanied by low-grade systemic inflammation, and, theoretically, obesity-induced proinflammatory mechanisms may exacerbate psoriatic lesions in overweight patients with psoriasis. 16 At present, the role of weight loss as a treatment for psoriasis in obese patients is unclear, but it is reasonable to assume that weight loss in such patients may reduce the obesity-induced inflammation, which may in turn improve the skin disease.…”
“…[6][7][8][9][10][11][12][13]15 Obesity apparently predisposes to the development of psoriasis and vice versa, although there is less evidence for the latter. [6][7][8][9][10][11][12][13]15 Two studies have provided results suggesting that patients with psoriasis gain weight after the onset of the condition. Herron et al 32 presented retrospective data from 557 patients with psoriasis and concluded that obesity did not seem to have a role in the onset of psoriasis.…”
Section: Discussionmentioning
confidence: 99%
“…[4][5][6] In addition, epidemiological studies have established that psoriasis is associated with obesity and that increased adiposity and weight gain are risk factors for incident psoriasis. [6][7][8][9][10][11][12][13][14][15] Like psoriasis, obesity is accompanied by low-grade systemic inflammation, and, theoretically, obesity-induced proinflammatory mechanisms may exacerbate psoriatic lesions in overweight patients with psoriasis. 16 At present, the role of weight loss as a treatment for psoriasis in obese patients is unclear, but it is reasonable to assume that weight loss in such patients may reduce the obesity-induced inflammation, which may in turn improve the skin disease.…”
“…Weight gain from the age of 18 years, higher waist circumference, hip circumference, and waist-hip ratio were all associated with a higher risk of incident psoriasis [40] . In 2010, Bryld et al [41] conducted a study exploring the temporal relationship between obesity and psoriasis. The study cohort included 309,152 school children and found that, for women, severe psoriasis resulting in hospitalization in adulthood was preceded by an increased BMI at the age of 12.…”
Section: Association Between Psoriasis and Obesitymentioning
Psoriasis is a common chronic inflammatory skin disease with a complex pathogenesis consisting of a genetic component, immune dysfunction, and environmental factors. It is associated with numerous comorbidities including psoriatic arthritis, cardiovascular disease, metabolic syndrome, and obesity. Evidence suggests that obesity is a risk factor for incident psoriasis, aggravates existing psoriasis, and that weight reduction may improve the severity of psoriasis in overweight individuals. Excess body weight may interfere with the medical treatment used in psoriasis and adds to the cardiovascular risk profile in these patients, which underscores the importance of effective weight control regimens. In this review we examine the current literature with regard to the association between obesity and psoriasis.
“…Others include calcium channel blockers, interferon, terbinafine, diazepam, and antibiotics (especially tetracycline). [35][36][37][38] weight A prospective study by Setty et al 39 suggested that women with a higher body mass index (BMI) were more prone to psoriasis; this finding was confirmed by a study by Bryld et al 40 Zhang et al studied 4,452 subjects with psoriasis vulgaris and 1,166 healthy individuals, and found that overweightness and obesity occurred in 23% and 4% of subjects with psoriasis, respectively, which was significantly higher than controls. Severity of psoriasis and Psoriasis Area and …”
Background: Psoriasis is a chronic inflammatory skin disease that has a negative impact on quality of life. Prevalence and management of psoriasis varies among different ethnic groups. Objectives: To evaluate the epidemiology and treatment of psoriasis from a Chinese perspective. Methods: A systematic search was performed on PubMed and the China National Knowledge Infrastructure using the following MeSH terms: "psoriasis" and ("prevalence" or "epidemiology") and "risk factor" and ("management" or "treatment"). The search included all citations from 1975 to 2013. Data were sorted by prevalence, age of onset, sex distribution, type, severity, risk factors, and management and treatment. Severity of psoriasis was classified as mild, moderate, or severe. The studies cited in this review involved Chinese subjects. Results: The prevalence of psoriasis in the People's Republic of China ranged from 0.11% to 0.47%. Genetic and environmental factors played an important role in initiation and exacerbation of psoriasis. Results showed that psoriasis can occur at any age but is more common in young and middle-aged individuals and occurs more often in men and earlier in women. Psoriasis vulgaris accounted for 82.6%-97.1% of psoriasis patients. More than 90% of patients with psoriasis were classified as mild or moderately severe. Risk factors are numerous. Management and treatment was based on classification level.
Conclusion:The prevalence of psoriasis in Chinese patients is lower than that in Caucasians. A cold and dry climate, bacterial infection, diet, and stress are important risk factors for developing psoriasis. There are a variety of management and treatment options available. As such, Chinese patients with psoriasis can receive effective, safe, and individualized treatment.
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