High-BMI at diagnosis is associated with inferior survival in patients with osteosarcoma: A report from the Children's Oncology Group

Altaf, Sadaf; Enders, Felicity; Jeavons, Elysia N.; Krailo, Mark; Barkauskas, Donald A.; Meyers, Paul A.; Arndt, Carola A.S.

doi:10.1002/pbc.24580

Cited by 33 publications

(33 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moore et al also reported obesity to be an independent risk factor for major wound complications after soft tissue sarcoma resection [42]. While we did not find any association between obesity and adverse events or diagnostic accuracy, some have reported high BMI at diagnosis to be associated with poorer survival in patients with osteosarcoma [43], although Bielack and Kevric noted this finding could be explained by other socioeconomic or healthcare factors [44]. Identifying these patients at potential risk early on may help in the patient education process.…”

Section: Discussioncontrasting

confidence: 54%

Initial diagnostic management of pediatric bone tumors

Interiano

Malkan

Loh

et al. 2016

Journal of Pediatric Surgery

View full text Add to dashboard Cite

Background Osteosarcoma (OS) and the Ewing sarcoma family of tumors (ESFT) are the most common primary pediatric bone malignancies. We sought to assess the diagnostic accuracy of initial tumor biopsies in patients with OS or ESFT at a pediatric cancer center. Methods All biopsies performed at initial presentation of patients with OS or ESFT at our institution from 2003 to 2012 were retrospectively reviewed. Diagnostic accuracy and incidence of complications were correlated with study variables using logistic regression analysis. Results One hundred forty-two biopsies were performed in 105 patients (median age 13.4 years, range: 1.8-23.0), 104 (73.2%) OS and 38 (27.8%) ESFT. Thirty-one (21.8%) were performed on metastatic sites. Eighty-five (76.6%) of 111 primary site biopsies were open procedures, and 26 were percutaneous (23.4%). Primary site biopsies were successful in 94.1% of open and 73.1% of percutaneous procedures. Odds of obtaining a successful diagnostic specimen were 7.8 times higher with open approach (CI: 1.6-36.8). Metastatic site biopsies were successful in 66.7% of percutaneous and 100% of open and thoracoscopic procedures. Conclusion Biopsy of metastatic sites was equal to primary site in obtaining diagnostic material with the added benefit of accurate staging, with few adverse events and high diagnostic yield.

show abstract

Section: Discussioncontrasting

confidence: 54%

Initial diagnostic management of pediatric bone tumors

Interiano

Malkan

Loh

et al. 2016

Journal of Pediatric Surgery

View full text Add to dashboard Cite

show abstract

“…The incidence of obesity in the US continues to increase, and negatively impacts overall health and quality of life . Furthermore, evidence is accumulating that obesity has a specific and negative prognostic influence on patients with malignant conditions . In the orthopedic setting, obesity is a recognized comorbidity in the management of numerous musculoskeletal conditions, and has been associated with significant complications of surgical procedures, such as joint arthroplasty and trauma .…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, obesity has been associated with increased morbidity that can complicate surgery, chemotherapy, and/or radiation therapies . For osteosarcoma, obesity has been associated with not only wound complications but also the potential for decreased overall survival …”

Section: Introductionmentioning

confidence: 99%

Obesity is associated with larger soft‐tissue sarcomas, more surgical complications, and more complex wound closures (obesity leads to larger soft‐tissue sarcomas)

Montgomery

Harris

Siegel

et al. 2018

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

“…A high body mass index (defined as greater than 85 th percentile based on the Center for Disease Control and Prevention) was associated with inferior survival in pediatric osteosarcoma patients and those with acute myeloid leukemia. (31–33) Similarly, obesity is associated with inferior survival among adult cancer patients with common malignancies. (34) As the prevalence of obesity increases in the AYA population, it is imperative to learn of its consequences on treatment, morbidity and mortality.…”

Section: Discussionmentioning

confidence: 99%

Impact of the AYA HOPE Comorbidity Index on Assessing Health Care Service Needs and Health Status among Adolescents and Young Adults with Cancer

Prasad

Landry

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background Existing comorbidity indices were not developed for adolescent and young adults (AYA) 15–39 years of age. The aim of this study was to assess impact of comorbidities on healthcare service needs and health status among AYA cancer survivors using the newly developed AYA HOPE comorbidity index in comparison with the existing indices. Methods Data on comorbid conditions were obtained from medical records and service needs and health status were from a survey of AYA cancer survivors. Prevalence of comorbidities based on the AYA HOPE index. Charlson and NCI indices) were compared. Multivariable logistic regression was employed. Results Of the 485 patients, 14.6% had ≥2 comorbidities based on the AYA HOPE Index. Prevalence of mental illness and obesity/overweight, which were not included in existing indices, were 8.2% and 5.8%, respectively. Prevalence of cardiovascular, endocrine, gastrointestinal and neurologic conditions were higher with the AYA HOPE Index than the other two indices. Forty percent of AYA patients reported service needs, particularly for mental health services (25.2%) and support groups (17.7%). Having ≥2 comorbidities on the AYA index was associated with higher mental health service needs (OR: 2.05; 95% CI 1.10–3.82) adjusting for demographic and clinical factors. Comorbidities were associated with fair/poor self-reported health status. Conclusion The AYA HOPE Index is a more comprehensive comorbidity index for AYA cancer patients than existing indices and the number of comorbidities is associated with service needs and health status. Impact The AYA HOPE index could identify patients’ additional service needs early in therapy.

show abstract

High-BMI at diagnosis is associated with inferior survival in patients with osteosarcoma: A report from the Children's Oncology Group

Abstract: High BMI at diagnosis is associated with worse OAS in patients with osteosarcoma. No clinically significant differences in toxicity were observed in the various BMI groups.

Cited by 33 publications

References 20 publications

Initial diagnostic management of pediatric bone tumors

Initial diagnostic management of pediatric bone tumors

Obesity is associated with larger soft‐tissue sarcomas, more surgical complications, and more complex wound closures (obesity leads to larger soft‐tissue sarcomas)

Impact of the AYA HOPE Comorbidity Index on Assessing Health Care Service Needs and Health Status among Adolescents and Young Adults with Cancer

Contact Info

Product

Resources

About