High Blood Pressure, Bone-Mineral Loss and Insulin Resistance in Women

Gotoh, Mitsuhiro; Mizuno, Kenji; Ōno, Yoshiaki; Takahashi, Michihiko

doi:10.1291/hypres.28.565

Cited by 46 publications

(47 citation statements)

References 36 publications

(24 reference statements)

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“…Although type 1 diabetes mellitus has been repor ted to be associated with a decrease of BMD 32) , reports on the status of the BMD in type 2 diabetes mellitus are confliting 33) . We observed that hypertension might be associated with reduced BMD in female essential hypertension 34) . The present prospective study was aimed of evaluating the effect of 3 -year treatment with fluvastatin at 30 mg/day on the BMD and bone turnover in non -diabetic, normotensive and postmenopausal hypercholesterolemic women.…”

Section: Hydroxymentioning

confidence: 65%

Fluvastatin Increases Bone Mineral Density in Postmenopausal Women

Gotoh

Mizuno

Ōno

et al. 2011

FJMS

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:Although several studies have reported a lower risk of osteoporotic fracture in hypercholesterolemic patients (WHO IIa) treated with statin, longitudinal studies on the effects of statins on bone are lacking. The aim of the present study was to evaluate bone mineral density (BMD) and bone turnover changes induced by 3 -year fluvastatin treatment in postmenopausal women. Twenty -eight consecutive postmenopausal non -diabetic, normotensive hypercholesterolemic women (64.0±3.6 years) were treated for 36 months with 30 mg/day fluvastatin and 28 non -diabetic, normotensive normocholesterolemic age -and body mass index -matched postmenopausal women served as the control subjects. The result revealed a significant increase of the BMD as compared with the level at the base line (p<0.001) in the fluvastairn -treated group, from 6 months on ward after the start treatment. Significant differences of the BMD were found between the controls and fluvastatin -treated group (p<0.001) were at 6, 12, 24 and 36 months after the start of the study. In conclusion our results, although obtained small sample of postmenopausal hypercholesterolemic women, suggest a probable favorable effect of fluvastatin on bone formation and BMD.

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Section: Hydroxymentioning

confidence: 65%

Fluvastatin Increases Bone Mineral Density in Postmenopausal Women

Gotoh

Mizuno

Ōno

et al. 2011

FJMS

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“…12 Together, the results of our and these experimental studies support the clinical investigations documenting an association between low bone mineral density (BMD) and high blood pressure. Cappuccio et al(1999), 2 evaluating 3,676 women, showed that 13 demonstrated that the BMD in the lumbar spine in women with normotension was higher than that of women with essential hypertension. Although the precise pathophysiological mechanisms by which hypertension could have a harmful effect on bone density are still unclear.…”

Section: Discussionmentioning

confidence: 99%

“…smoking, diabetes and osteoporosis) have been shown to affect bone density and healing. 8,9 Although the hypothesis that hypertension may have a harmful effect on bone density was previously evaluated in a series of animal and clinical studies, [10][11][12][13][14] to date, few investigations have focused on the influence of hypertension on bone healing. 15 Currently the hypothesis that the hypertension could lead to an increased incidence of late implant loss was evaluated by Alsaadi et al (2008).…”

Section: Introductionmentioning

confidence: 99%

Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study

et al. 2010

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Abstract:Clinical and experimental studies have demonstrated some negative effect of hypertension on bone mineral density. The aim of this study was to evaluate bone healing and trabecular bone area (TBA) in spontaneously hypertensive rats (SHR), a well-established model of essential hypertension, when compared to normotensive rats (NTR). A critical-size defect was surgically created in the right tibia of SHR (n = 12) and normotensive rats (NTR; n = 12), while the contralateral tibia was left intact. Eight days later, the animals were sacrificed and the specimens processed in order to obtain decalcified sections. The area of newly-formed bone (NB) within the defect of the right tibia and the TBA in the left tibia were histometrically evaluated. At 8 days post-operative, SHR presented a significantly smaller area of NB when compared to NTR (p < 0.05). In addition, SHR demonstrated a lower TBA than NTR group. In conclusion, the present study demonstrated that SHR rats presented a disturbed bone healing and reduced TBA.

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“…3 Urinary calcium excretion is inversely correlated to BMD, whereas serum total and ionized calcium levels in hypertensive women are not different from those observed in normotensive women. 4,5 Diastolic hypertensive men have reduced bone mineral content when compared with normotensive subjects. 6,7 On the other hand, some reports have failed to reveal a consistent relation between urinary calcium excretion and hypertension in men as well.…”

Section: Introductionmentioning

confidence: 99%

Bone healing of mandibular critical-size defects in spontaneously hypertensive rats

2013

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Few articles have shown changes in bone metabolism caused by hypertension. The objective of this study was to investigate the relationship between hypertension and bone healing. Circular critical-size defects 5 mm and 2 mm in diameter were created, respectively, on the left and right side of the mandible in 40 spontaneously hypertensive and 40 control Wistar-Kyoto rats. Five animals from each strain were killed 2, 3, 5, 10, 15, 30, 60 and 90 days after surgery. The macroscopic evaluation showed great mandibular angle deformation on the left side and non-healed defects on both sides and groups. Histological evaluation revealed similar bone healing on both sides, with initial necrosis in the central area, and fibrosis and angiogenesis within the first 5 days. From the 10 th postoperative day on, the newly formed bone displayed progressive thickening until the 90 th postoperative day, when the defect margins presented a compact bone structure. Furthermore, the statistical analysis of the histometric data did not reveal any significant hypertension effect on bone healing in the defect area. These results suggest that bone healing was not different between spontaneously hypertensive rats and control rats.

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High Blood Pressure, Bone-Mineral Loss and Insulin Resistance in Women

Cited by 46 publications

References 36 publications

Fluvastatin Increases Bone Mineral Density in Postmenopausal Women

Fluvastatin Increases Bone Mineral Density in Postmenopausal Women

Trabecular bone area and bone healing in spontaneously hypertensive rats: a histometric study

Bone healing of mandibular critical-size defects in spontaneously hypertensive rats

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